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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 CEP/COS, 1 EU WC, 2 Listed Suppliers, $ API Reference Price

4 API Suppliers
1 CEP/COS
1 EU WC
2 Listed Suppliers
$ API Reference Price

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 428

MARKET PLACE

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FDF

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Chemistry

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Also known as: 36105-20-1, Dalmate, 7c4jh842ij, Dalmadorm, Dalmane, Felison

Molecular Formula

C₂₁H₂₄Cl₂FN₃O

Molecular Weight

424.3 g/mol

InChI Key

PUGVROXLRUQCAF-UHFFFAOYSA-N

FDA UNII

7C4JH842IJ

A benzodiazepine derivative used mainly as a hypnotic.

1 2D Structure

Flurazepam Monohydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;hydrochloride

2.1.2 InChI

InChI=1S/C21H23ClFN3O.ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;/h5-10,13H,3-4,11-12,14H2,1-2H3;1H

2.1.3 InChI Key

PUGVROXLRUQCAF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl

2.2 Other Identifiers

2.2.1 UNII

7C4JH842IJ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apo Flurazepam

2. Apo-flurazepam

3. Dalmadorm

4. Dalmane

5. Dihydrochloride, Flurazepam

6. Dormodor

7. Flurazepam

8. Flurazepam Dihydrochloride

9. Flurazepam Hydrochloride

10. Flurazepam Mono Perchlorate

11. Flurazepam Mono-perchlorate

12. Hydrochloride, Flurazepam

13. Mono-perchlorate, Flurazepam

14. Monohydrochloride, Flurazepam

15. Staurodorm

2.3.2 Depositor-Supplied Synonyms

1. 36105-20-1

2. Dalmate

3. 7c4jh842ij

4. Dalmadorm

5. Dalmane

6. Felison

7. Linzac

8. Natam

9. Insumin Dihydrochloride

10. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;hydrochloride

11. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Monohydrochloride

12. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

13. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

14. Id 480

15. Einecs 252-867-1

16. Unii-7c4jh842ij

17. Fluzepam

18. Dalmate (tn)

19. Fluorazepam Hydrochloride

20. Schembl29794

21. Chebi:31626

22. Flurazepam Hydrochloride (jp17)

23. Dtxsid40189686

24. Nsc78559

25. Flurazepam Monohydrochloride [mart.]

26. D01408

27. Flurazepam Monohydrochloride [ep Monograph]

28. Q27268050

29. Wln: T67 Gnv Jn Ihj Cg G2n2&2 Kr Bf &gh 2

30. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

31. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-, Dihydrochloride

32. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

33. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Hydrochloride (1:1)

34. 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,4-benzodiazepin-2-one Dihydrochloride

35. Flurazepam Monohydrochloride; 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride; 2h-1,4-benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₄Cl₂FN₃O
Molecular Weight	424.3 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	423.1280459 g/mol
Monoisotopic Mass	423.1280459 g/mol
Topological Polar Surface Area	35.9 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	540
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

2 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

API SUPPLIERS

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ABOUT THIS PAGE

Flurazepam Monohydrochloride Manufacturers

A Flurazepam Monohydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Flurazepam Monohydrochloride, including repackagers and relabelers. The FDA regulates Flurazepam Monohydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Flurazepam Monohydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Flurazepam Monohydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Flurazepam Monohydrochloride Suppliers

A Flurazepam Monohydrochloride supplier is an individual or a company that provides Flurazepam Monohydrochloride active pharmaceutical ingredient (API) or Flurazepam Monohydrochloride finished formulations upon request. The Flurazepam Monohydrochloride suppliers may include Flurazepam Monohydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Flurazepam Monohydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Flurazepam Monohydrochloride CEP

A Flurazepam Monohydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Flurazepam Monohydrochloride Certificate of Suitability (COS). The purpose of a Flurazepam Monohydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Flurazepam Monohydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Flurazepam Monohydrochloride to their clients by showing that a Flurazepam Monohydrochloride CEP has been issued for it. The manufacturer submits a Flurazepam Monohydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Flurazepam Monohydrochloride CEP holder for the record. Additionally, the data presented in the Flurazepam Monohydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Flurazepam Monohydrochloride DMF.

A Flurazepam Monohydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Flurazepam Monohydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Flurazepam Monohydrochloride suppliers with CEP (COS) on PharmaCompass.

Flurazepam Monohydrochloride WC

A Flurazepam Monohydrochloride written confirmation (Flurazepam Monohydrochloride WC) is an official document issued by a regulatory agency to a Flurazepam Monohydrochloride manufacturer, verifying that the manufacturing facility of a Flurazepam Monohydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Flurazepam Monohydrochloride APIs or Flurazepam Monohydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Flurazepam Monohydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Flurazepam Monohydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Flurazepam Monohydrochloride GMP

Flurazepam Monohydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Flurazepam Monohydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Flurazepam Monohydrochloride GMP manufacturer or Flurazepam Monohydrochloride GMP API supplier for your needs.

Flurazepam Monohydrochloride CoA

A Flurazepam Monohydrochloride CoA (Certificate of Analysis) is a formal document that attests to Flurazepam Monohydrochloride's compliance with Flurazepam Monohydrochloride specifications and serves as a tool for batch-level quality control.

Flurazepam Monohydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Flurazepam Monohydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Flurazepam Monohydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Flurazepam Monohydrochloride EP), Flurazepam Monohydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Flurazepam Monohydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.