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    Chemistry

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    Also known as: 80474-14-2, Flovent, Cutivate, Flixotide, Flonase, Flixonase
    Molecular Formula
    C25H31F3O5S
    Molecular Weight
    500.6  g/mol
    InChI Key
    WMWTYOKRWGGJOA-CENSZEJFSA-N
    FDA UNII
    O2GMZ0LF5W
    Fluticasone Propionate
    A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS.
    1 2D Structure

    Fluticasone Propionate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
    2.1.2 InChI
    InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
    2.1.3 InChI Key
    WMWTYOKRWGGJOA-CENSZEJFSA-N
    2.1.4 Canonical SMILES
    CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
    2.1.5 Isomeric SMILES
    CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF
    2.2 Other Identifiers
    2.2.1 UNII
    O2GMZ0LF5W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cutivate

    2. Flixonase

    3. Flixotide

    4. Flonase

    5. Flovent

    6. Flovent Hfa

    7. Fluticasone

    8. Hfa, Flovent

    9. Propionate, Fluticasone

    2.3.2 Depositor-Supplied Synonyms

    1. 80474-14-2

    2. Flovent

    3. Cutivate

    4. Flixotide

    5. Flonase

    6. Flixonase

    7. Flovent Hfa

    8. Flunase

    9. Flusonal

    10. Fluspiral

    11. Flutide

    12. Flutivate

    13. Asmatil

    14. Axotide

    15. Brethal

    16. Fluinol

    17. Flovent Diskus 50

    18. Flixotide Disks

    19. Flixotide Disk

    20. Flovent Diskus

    21. Flovent Diskus 100

    22. Flovent Diskus 250

    23. Flixotide Inhaler

    24. Cultivate

    25. Flixonase Nasal Spray

    26. Fluticasonpropionat Allen

    27. Cci-18781

    28. Xhance

    29. Fluticasone (propionate)

    30. Cci 18781

    31. Armonair Respiclick

    32. Fluticasone-17-propionate

    33. O2gmz0lf5w

    34. Atemur

    35. Chebi:31441

    36. Nsc-759889

    37. Inalacor

    38. Rinosone

    39. Trialona

    40. Ubizol

    41. Zoflut

    42. Fluticasone Propionate (flonase, Veramyst)

    43. Mfcd00866007

    44. Flonase Aq

    45. Pf-00241939

    46. [(6s,8s,9r,10s,11s,13s,14s,16r,17r)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Propanoate

    47. Flovent-hfa

    48. Fluticasone Propionate [usan]

    49. Unii-o2gmz0lf5w

    50. Fluxonal

    51. Skyron

    52. Flovent Rotadisk

    53. Cutivate (tn)

    54. Fluticasone Propionate [usan:usp]

    55. Flonase (tn)

    56. Flovent (tn)

    57. Fluticasone-propionate

    58. Armonair Respiclicktm

    59. Flonase Allergy Relief

    60. Fluticasone Impurity B

    61. Prestwick0_000997

    62. Prestwick1_000997

    63. Prestwick2_000997

    64. Prestwick3_000997

    65. Cci18781

    66. Schembl4068

    67. Chembl1473

    68. Bspbio_001093

    69. Mls001424085

    70. S-(fluoromethyl) 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate, 17-propionate

    71. Fluticasone Propionate- Bio-x

    72. Spbio_002984

    73. Bpbio1_001203

    74. Gtpl7080

    75. Dtxsid8045511

    76. Fluticasone Propionate (jan/usp)

    77. Fn-25

    78. Hms1571g15

    79. Hms2051n19

    80. Hms2098g15

    81. Hms3413a19

    82. Hms3677a19

    83. Hms3715g15

    84. Fluticasone Propionate [mi]

    85. Amy38235

    86. Hy-b0154

    87. Ymb56612

    88. Zinc3920027

    89. Fluticasone Propionate [jan]

    90. Ac-457

    91. Bdbm50354849

    92. S1992

    93. Fluticasone Propionate [vandf]

    94. Akos015895220

    95. Fluticasone Propionate [mart.]

    96. Ccg-100981

    97. Cci-187881

    98. Cs-1986

    99. Db00588

    100. Fluticasone Propionate [usp-rs]

    101. Fluticasone Propionate [who-dd]

    102. Ks-1173

    103. Nc00231

    104. Nsc 759889

    105. Ncgc00179308-01

    106. Ncgc00179308-05

    107. Androsta-1,4-diene-17-carbothioic Acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, (6alpha,11beta,16alpha,17alpha)-s-(fluoromethyl) Ester

    108. Bf160362

    109. Bf161262

    110. Smr000469159

    111. Fluticasone Propionate [orange Book]

    112. Ab00513992

    113. Fluticasone Propionate [ep Monograph]

    114. Advair Component Fluticasone Propionate

    115. Fluticasone Propionate [usp Monograph]

    116. A51110

    117. D01708

    118. Dymista Component Fluticasone Propionate

    119. Ab00513992-06

    120. Ab00513992_08

    121. Fluticasone Propionate - Micronised Pharma Grade

    122. Fluticasone Propionate Component Of Advair

    123. Fluticasone Propionate, >=98% (hplc), Powder

    124. 474f142

    125. Advair Hfa Component Fluticasone Propionate

    126. An-584/43505443

    127. Fluticasone Propionate 100 Microg/ml In Methanol

    128. Fluticasone Propionate Component Of Dymista

    129. Lipo-102 Component Fluticasone Propionate

    130. Sr-01000763355

    131. Q-101393

    132. Q8564098

    133. Sr-01000763355-3

    134. Brd-k62310379-001-03-0

    135. Fluticasone Propionate 100 Microg/ml In Acetonitrile

    136. Fluticasone Propionate Component Of Advair Hfa

    137. Airduo Respiclick Component Fluticasone Propionate

    138. Fluticasone 17(2)-carbonylsulfenic Acid 17-propionate

    139. Fluticasone Propionate Component Of Airduo Respiclick

    140. Fluticasone Propionate, European Pharmacopoeia (ep) Reference Standard

    141. Fluticasone Propionate, United States Pharmacopeia (usp) Reference Standard

    142. Fluticasone Propionate, Pharmaceutical Secondary Standard; Certified Reference Material

    143. (1r,2s,8s,10s,11s,13r,14r,15s,17s)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl Propanoate

    144. (6?,11?,16?,17?)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid Fluoromethyl Ester

    145. 6alpha,9-difluoro-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-11beta-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17alpha-yl Propanoate

    146. Androsta-1,4-diene-17-carbothioic Acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-s-(fluoromethyl) Ester

    147. Androsta-1,4-diene-17-carbothioic Acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-,s-(fluoromethyl) Ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-

    148. Fluticasone Propionate For Impurity C Identification, Europepharmacopoeia (ep) Reference Standard

    149. Fluticasone Propionate For Impurity G Identification, Europepharmacopoeia (ep) Reference Standard

    150. S-fluoromethyl 6.alpha., 9.alpha.-difluoro-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-17.alpha.-propionyloxyandrosta-1,4-diene-17.beta-. Carbothioate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 500.6 g/mol
    Molecular Formula C25H31F3O5S
    XLogP34
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count6
    Exact Mass500.18442974 g/mol
    Monoisotopic Mass500.18442974 g/mol
    Topological Polar Surface Area106 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity984
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 14  
    Drug NameCutivate
    PubMed HealthFluticasone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Strong
    Drug LabelCUTIVATE (fluticasone propionate cream) Cream, 0.05% contains fluticasone propionate [(6,11,16,17)-6,9,-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid, S-fluoromethyl ester], a synthetic fluorina...
    Active IngredientFluticasone propionate
    Dosage FormLotion; Ointment
    RouteTopical
    Strength0.05%; 0.005%
    Market StatusPrescription
    CompanyFougera Pharms

    2 of 14  
    Drug NameFlonase
    Drug LabelThe active component of FLOVENT HFA 44 mcg Inhalation Aerosol, FLOVENT HFA 110 mcg Inhalation Aerosol, and FLOVENT HFA 220 mcg Inhalation Aerosol is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6,9-difluoro-11...
    Active IngredientFluticasone propionate
    Dosage FormSpray, metered
    RouteNasal
    Strength0.05mg/spray
    Market StatusPrescription
    CompanyGlaxosmithkline

    3 of 14  
    Drug NameFlovent diskus 100
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.1mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    4 of 14  
    Drug NameFlovent diskus 250
    Drug LabelFluticasone propionate, the active component of Fluticasone Propionate Nasal Spray USP, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6,9-difluoro-11-17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate, 17-...
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.25mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    5 of 14  
    Drug NameFlovent diskus 50
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.05mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    6 of 14  
    Drug NameFlovent hfa
    Active IngredientFluticasone propionate
    Dosage FormAerosol, metered
    RouteInhalation
    Strength0.22mg/inh; 0.11mg/inh; 0.044mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    7 of 14  
    Drug NameFluticasone propionate
    Drug LabelFluticasone propionate, the active component of FLONASE Nasal Spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6,9-difluoro-11-17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate, 17-propionate and the...
    Active IngredientFluticasone propionate
    Dosage FormOintment; Spray, metered; Cream; Lotion
    RouteNasal; Topical
    Strength0.05%; 0.005%; 0.05mg/spray
    Market StatusPrescription
    CompanyWockhardt; Apotex; Roxane; Glenmark Generics; Fougera Pharms; Hi Tech Pharma; Perrigo New York; Tolmar; G And W Labs; Perrigo Israel

    8 of 14  
    Drug NameFlovent diskus 250
    Drug LabelFluticasone propionate, the active component of Fluticasone Propionate Nasal Spray USP, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6,9-difluoro-11-17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate, 17-...
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.25mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    9 of 14  
    Drug NameFlovent diskus 50
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.05mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    10 of 14  
    Drug NameFlovent hfa
    Active IngredientFluticasone propionate
    Dosage FormAerosol, metered
    RouteInhalation
    Strength0.22mg/inh; 0.11mg/inh; 0.044mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    11 of 14  
    Drug NameFluticasone propionate
    Drug LabelFluticasone propionate, the active component of FLONASE Nasal Spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6,9-difluoro-11-17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate, 17-propionate and the...
    Active IngredientFluticasone propionate
    Dosage FormOintment; Spray, metered; Cream; Lotion
    RouteNasal; Topical
    Strength0.05%; 0.005%; 0.05mg/spray
    Market StatusPrescription
    CompanyWockhardt; Apotex; Roxane; Glenmark Generics; Fougera Pharms; Hi Tech Pharma; Perrigo New York; Tolmar; G And W Labs; Perrigo Israel

    12 of 14  
    Drug NameCutivate
    PubMed HealthFluticasone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Strong
    Drug LabelCUTIVATE (fluticasone propionate cream) Cream, 0.05% contains fluticasone propionate [(6,11,16,17)-6,9,-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid, S-fluoromethyl ester], a synthetic fluorina...
    Active IngredientFluticasone propionate
    Dosage FormLotion; Ointment
    RouteTopical
    Strength0.05%; 0.005%
    Market StatusPrescription
    CompanyFougera Pharms

    13 of 14  
    Drug NameFlonase
    Drug LabelThe active component of FLOVENT HFA 44 mcg Inhalation Aerosol, FLOVENT HFA 110 mcg Inhalation Aerosol, and FLOVENT HFA 220 mcg Inhalation Aerosol is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6,9-difluoro-11...
    Active IngredientFluticasone propionate
    Dosage FormSpray, metered
    RouteNasal
    Strength0.05mg/spray
    Market StatusPrescription
    CompanyGlaxosmithkline

    14 of 14  
    Drug NameFlovent diskus 100
    Active IngredientFluticasone propionate
    Dosage FormPowder
    RouteInhalation
    Strength0.1mg/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    4.2 Drug Indication

    Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses. Fluticasone propionate nasal spray is indicated for managing allergic and nonallergic rhinitis.

    FDA Label

    Treatment of asthma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats. Fluticasone propionate as a topical formulation is also associated with vasoconstriction in the skin.

    5.2 MeSH Pharmacological Classification

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Dermatologic Agents

    Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
    5.4 Absorption, Distribution and Excretion

    Absorption

    Intranasal bioavailability of fluticasone propionate is <2%, and oral bioavailability is <1%. Intranasal exposure results in the majority of the dose being swallowed. Topical absorption of fluticasone propionate is very low but can change depending on a number of factors including integrity of the skin and the presence of inflammation or disease. A study of 24 healthy Caucasian males showed an inhaled bioavailability of 9.0%.

    Route of Elimination

    Fluticasone propionate is mainly eliminated in the feces with <5% eliminated in the urine.

    Volume of Distribution

    The volume of distribution of intravenous fluticasone propionate is 4.2L/kg. A study of 24 healthy Caucasian males showed a volume of distribution at steady state of 577L following intravenous administration.

    Clearance

    1093mL/min for fluticasone propionate. A study of 24 healthy Caucasian males showed a clearance of 63.9L/h following intravenous administration.

    5.5 Metabolism/Metabolites

    Fluticasone propionate is cleared from hepatic metabolism by cytochrome P450 3A4. Fluticasone propionate is hydrolysed at the FIVE-S-fluoromethyl carbothioate group, forming an inactive metabolite.

    5.6 Biological Half-Life

    7.8 hours for intravenous fluticasone propionate. A study of 24 healthy Caucasian males shows a half life of 14.0 hours following intravenous administration and 10.8 hours following inhalation.

    5.7 Mechanism of Action

    Fluticasone propionate works through an unknown mechanism to affect the action of various cell types and mediators of inflammation. Fluticasone propionate activates glucocorticoid receptors and inhibits lung eosinophilia in rats.

    API Reference Price

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HEALTHCARE","customerCountry":"INDIA","quantity":"0.28","actualQuantity":"280","unit":"GMS","unitRateFc":"23","totalValueFC":"6566.5","currency":"USD","unitRateINR":"1929.7","date":"31-Oct-2022","totalValueINR":"540316","totalValueInUsd":"6566.5","indian_port":"AHMEDABAD AIR","hs_no":"29372200","bill_no":"3097353","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"COMMERCE HOUSE V BESIDES VODAFONE HOUSE PRAHLADNAGAR CORPORATE RD Con"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1669228200,"product":"FLUTICASONE PROPIONATE (MICRONISED) IP","address":"DR ANNIE BESANT ROAD,WORLI","city":"MUMBAI,MAHARASHTRA","supplier":"GSK","supplierCountry":"UNITED KINGDOM","foreign_port":"NA","customer":"GSK","customerCountry":"INDIA","quantity":"6.32","actualQuantity":"6317","unit":"GMS","unitRateFc":"40","totalValueFC":"305738.7","currency":"GBP","unitRateINR":"3950","date":"24-Nov-2022","totalValueINR":"24952150","totalValueInUsd":"305738.7","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"3451614","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"DR ANNIE BESANT ROAD,WORLI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672597800,"product":"BATCH NO. 5501021017, 18, 19, 20 & 22 -FLUTICASONE PROPIONATE USP ( MICRONIZED ) ( REIMPORT)","address":"1001, AKASH DEEP BUILDING,26-A, BA RAKHAMBA ROAD","city":"DELHI,DELHI","supplier":"APOTEX INC","supplierCountry":"INDIA","foreign_port":"NA","customer":"CORAL DRUGS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"9.88","actualQuantity":"9.88","unit":"KGS","unitRateFc":"14000","totalValueFC":"141349.2","currency":"USD","unitRateINR":"1169700","date":"02-Jan-2023","totalValueINR":"11556636","totalValueInUsd":"141349.2","indian_port":"DELHI AIR","hs_no":"29221190","bill_no":"4008708","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"1001, AKASH DEEP BUILDING,26-A, BA RAKHAMBA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682015400,"product":"FLUTICASONE PROPIONATE (MICRONISED) IP","address":"DR ANNIE BESANT ROAD,WORLI","city":"MUMBAI,MAHARASHTRA","supplier":"GSK","supplierCountry":"UNITED KINGDOM","foreign_port":"NA","customer":"GSK","customerCountry":"INDIA","quantity":"2.12","actualQuantity":"2123","unit":"GMS","unitRateFc":"40","totalValueFC":"107764.2","currency":"GBP","unitRateINR":"4160","date":"21-Apr-2023","totalValueINR":"8831680","totalValueInUsd":"107764.2","indian_port":"BOMBAY AIR","hs_no":"29372200","bill_no":"5612765","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"DR ANNIE BESANT ROAD,WORLI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690828200,"product":"FLUTICASONE PROPIONATE MICRONISED IP","address":"DR ANNIE BESANT ROAD,WORLI","city":"MUMBAI","supplier":"GSK","supplierCountry":"UNITED KINGDOM","foreign_port":"NA","customer":"GSK","customerCountry":"INDIA","quantity":"4.22","actualQuantity":"4222","unit":"GMS","unitRateFc":"40","totalValueFC":"222068.1","currency":"GBP","unitRateINR":"4313.4","date":"01-Aug-2023","totalValueINR":"18395302.2","totalValueInUsd":"222068.1","indian_port":"SAHAR AIR","hs_no":"29372200","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"DR ANNIE BESANT ROAD,WORLI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698777000,"product":"FLUTICASONE PROPIONATE MICRONIZED (IGST EXEMPTED AS PER GST NOTIFICATION NO. 64\/2017)","address":"H.NO. 8-2-337,BESIDE TV9 OFFICE","city":"HYDERABAD ANDHRA PRADESH","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"DR. REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"20125","totalValueFC":"20349.6","currency":"USD","unitRateINR":"1694525","date":"01-Nov-2023","totalValueINR":"1694525","totalValueInUsd":"20349.6","indian_port":"Reddy r-SEZ\/Srikakulam","hs_no":"29093090","bill_no":"1000568","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702492200,"product":"FLUTICASONE PROPIONATE MICRONIZED","address":"221, GOREGAON-MULUND LINK ROAD,","city":"BHANDUP WEST, MUMBAI","supplier":"M\/S. CHEMO IBERICA, S.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"25000","totalValueFC":"25317.4","currency":"USD","unitRateINR":"2107500","date":"14-Dec-2023","totalValueINR":"2107500","totalValueInUsd":"25317.4","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"9223390","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RD FLOOR28050 MADRID -SPAINSDNF ES","customerAddress":"221, GOREGAON-MULUND LINK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704738600,"product":"FLUTICASONE PROPIONATE MICRONIZED","address":"221, GOREGAON-MULUND LINK ROAD,","city":"BHANDUP WEST, MUMBAI","supplier":"M\/S.CHEMO IBERICA, S.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.502","unit":"KGS","unitRateFc":"25000","totalValueFC":"12721.9","currency":"USD","unitRateINR":"2106250","date":"09-Jan-2024","totalValueINR":"1057337.5","totalValueInUsd":"12721.9","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"9588216","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RDFLOOR 28050 MADRID -SPAINSDNF ES","customerAddress":"221, GOREGAON-MULUND LINK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708713000,"product":"FLUTICASONE PROPIONATE MICRONIZED (BATCH : PR240222)","address":"221, GOREGAON-MULUND LINK ROAD,","city":"BHANDUP WEST, MUMBAI","supplier":"M\/S. CHEMO IBERICA, S.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"25000","totalValueFC":"6319.8","currency":"USD","unitRateINR":"2097500","date":"24-Feb-2024","totalValueINR":"524375","totalValueInUsd":"6319.8","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"2291527","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"MANUEL POMBO ANGULO, 28, 3RD FLOOR28050 MADRID -SPAINSDNF ES","customerAddress":"221, GOREGAON-MULUND LINK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710700200,"product":"FLUTICASONE PROPIONATE MICRONIZED","address":"H.NO. 8-2-337,BESIDE TV9 OFFICE","city":"HYDERABAD ANDHRA PRADESH","supplier":"CHEMO","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"DR. REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"0.025","unit":"KGS","unitRateFc":"35000","totalValueFC":"882.5","currency":"USD","unitRateINR":"2931250","date":"18-Mar-2024","totalValueINR":"73281.25","totalValueInUsd":"882.5","indian_port":"Hyderabad Air","hs_no":"29372200","bill_no":"2632167","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"MANUEL POMBO ANGULO,28,3RD FLOOR 28050 MADRID SPAIN Madrid, , SpainSDNF Spain","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725820200,"product":"FLUTICASONE PROPIONATE","address":"221, GOREGAON-MULUND LINK ROAD,","city":"BHANDUP WEST, MUMBAI","supplier":"AURISCO PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.05","unit":"KGS","unitRateFc":"50000","totalValueFC":"2532.8","currency":"USD","unitRateINR":"4245000","date":"09-Sep-2024","totalValueINR":"212250","totalValueInUsd":"2532.8","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"5508422","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"BADU INDUSTRIAL PARK ZONE TIANTAI,ZHEJIANG PROVINCE 317200, P.R.CHINA CN CN","customerAddress":"221, GOREGAON-MULUND LINK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733077800,"product":"ROW CHEMICALS FOR INDUSTRIAL USE 1,4 DIENE 17 BETA CARBOTHIOIC ACID 17 PROPIONATE(FOR FLUTICASONE PROPIONATE100 MG(SMPLE1, 4 DIENE 17 BETA","address":"805, AKASH DEEP BUILDING","city":"NEW DELHI.","supplier":"UNITED STATES PHARMACOPEIAL CONVE","supplierCountry":"UNITED STATES","foreign_port":"SINGAPORE","customer":"CORAL DRUGS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"23986.9","totalValueFC":"2409.4","currency":"USD","unitRateINR":"2047277.6","date":"02-Dec-2024","totalValueINR":"204727.76","totalValueInUsd":"2409.4","indian_port":"Delhi Air","hs_no":"29221190","bill_no":"7012621","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"NTION 12601 TWINBROOK PARKWAY ROCHVILLE MD 20852-1790 SDNF SDNF","customerAddress":"805, AKASH DEEP BUILDING"}]
    30-Jan-2021
    31-Dec-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - OINTMENT;TOPICAL - 0.005% **Federal ...DOSAGE - OINTMENT;TOPICAL - 0.005% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19957

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    DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY ...DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20121

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    DOSAGE - SPRAY, METERED;NASAL - 0.137MG/SPRAY...DOSAGE - SPRAY, METERED;NASAL - 0.137MG/SPRAY;0.05MG/SPRAY

    USFDA APPLICATION NUMBER - 202236

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    DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY

    USFDA APPLICATION NUMBER - 205434

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    DOSAGE - POWDER;INHALATION - 0.05MG/INH

    USFDA APPLICATION NUMBER - 20833

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    DOSAGE - POWDER;INHALATION - 0.1MG/INH

    USFDA APPLICATION NUMBER - 20833

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    DOSAGE - POWDER;INHALATION - 0.25MG/INH

    USFDA APPLICATION NUMBER - 20833

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    DOSAGE - POWDER;INHALATION - 0.03MG/INH

    USFDA APPLICATION NUMBER - 208798

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    DOSAGE - POWDER;INHALATION - 0.055MG/INH

    USFDA APPLICATION NUMBER - 208798

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    DOSAGE - POWDER;INHALATION - 0.113MG/INH

    USFDA APPLICATION NUMBER - 208798

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    DOSAGE - POWDER;INHALATION - 0.232MG/INH

    USFDA APPLICATION NUMBER - 208798

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    DOSAGE - POWDER;INHALATION - 0.055MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.055MG/INH;EQ 0.014MG BASE/INH

    USFDA APPLICATION NUMBER - 208799

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    DOSAGE - POWDER;INHALATION - 0.113MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.113MG/INH;EQ 0.014MG BASE/INH

    USFDA APPLICATION NUMBER - 208799

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    DOSAGE - POWDER;INHALATION - 0.232MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.232MG/INH;EQ 0.014MG BASE/INH

    USFDA APPLICATION NUMBER - 208799

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    DOSAGE - POWDER;INHALATION - 0.1MG/INH;EQ 0.0...DOSAGE - POWDER;INHALATION - 0.1MG/INH;EQ 0.05MG BASE/INH

    USFDA APPLICATION NUMBER - 21077

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    DOSAGE - POWDER;INHALATION - 0.25MG/INH;EQ 0....DOSAGE - POWDER;INHALATION - 0.25MG/INH;EQ 0.05MG BASE/INH

    USFDA APPLICATION NUMBER - 21077

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    DOSAGE - POWDER;INHALATION - 0.5MG/INH;EQ 0.0...DOSAGE - POWDER;INHALATION - 0.5MG/INH;EQ 0.05MG BASE/INH

    USFDA APPLICATION NUMBER - 21077

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    DOSAGE - LOTION;TOPICAL - 0.05% **Federal Reg...DOSAGE - LOTION;TOPICAL - 0.05% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21152

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.045M...DOSAGE - AEROSOL, METERED;INHALATION - 0.045MG/INH;EQ 0.021MG BASE/INH

    USFDA APPLICATION NUMBER - 21254

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.115M...DOSAGE - AEROSOL, METERED;INHALATION - 0.115MG/INH;EQ 0.021MG BASE/INH

    USFDA APPLICATION NUMBER - 21254

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.23MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.23MG/INH;EQ 0.021MG BASE/INH

    USFDA APPLICATION NUMBER - 21254

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.044M...DOSAGE - AEROSOL, METERED;INHALATION - 0.044MG/INH

    USFDA APPLICATION NUMBER - 21433

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.11MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.11MG/INH

    USFDA APPLICATION NUMBER - 21433

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.22MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.22MG/INH

    USFDA APPLICATION NUMBER - 21433

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    USP

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    ABOUT THIS PAGE

    Fluticasone Manufacturers

    A Fluticasone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fluticasone, including repackagers and relabelers. The FDA regulates Fluticasone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fluticasone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Fluticasone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Fluticasone Suppliers

    A Fluticasone supplier is an individual or a company that provides Fluticasone active pharmaceutical ingredient (API) or Fluticasone finished formulations upon request. The Fluticasone suppliers may include Fluticasone API manufacturers, exporters, distributors and traders.

    click here to find a list of Fluticasone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Fluticasone USDMF

    A Fluticasone DMF (Drug Master File) is a document detailing the whole manufacturing process of Fluticasone active pharmaceutical ingredient (API) in detail. Different forms of Fluticasone DMFs exist exist since differing nations have different regulations, such as Fluticasone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Fluticasone DMF submitted to regulatory agencies in the US is known as a USDMF. Fluticasone USDMF includes data on Fluticasone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fluticasone USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Fluticasone suppliers with USDMF on PharmaCompass.

    Fluticasone JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Fluticasone Drug Master File in Japan (Fluticasone JDMF) empowers Fluticasone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Fluticasone JDMF during the approval evaluation for pharmaceutical products. At the time of Fluticasone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Fluticasone suppliers with JDMF on PharmaCompass.

    Fluticasone KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Fluticasone Drug Master File in Korea (Fluticasone KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Fluticasone. The MFDS reviews the Fluticasone KDMF as part of the drug registration process and uses the information provided in the Fluticasone KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Fluticasone KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Fluticasone API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Fluticasone suppliers with KDMF on PharmaCompass.

    Fluticasone CEP

    A Fluticasone CEP of the European Pharmacopoeia monograph is often referred to as a Fluticasone Certificate of Suitability (COS). The purpose of a Fluticasone CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Fluticasone EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Fluticasone to their clients by showing that a Fluticasone CEP has been issued for it. The manufacturer submits a Fluticasone CEP (COS) as part of the market authorization procedure, and it takes on the role of a Fluticasone CEP holder for the record. Additionally, the data presented in the Fluticasone CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Fluticasone DMF.

    A Fluticasone CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Fluticasone CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Fluticasone suppliers with CEP (COS) on PharmaCompass.

    Fluticasone WC

    A Fluticasone written confirmation (Fluticasone WC) is an official document issued by a regulatory agency to a Fluticasone manufacturer, verifying that the manufacturing facility of a Fluticasone active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Fluticasone APIs or Fluticasone finished pharmaceutical products to another nation, regulatory agencies frequently require a Fluticasone WC (written confirmation) as part of the regulatory process.

    click here to find a list of Fluticasone suppliers with Written Confirmation (WC) on PharmaCompass.

    Fluticasone NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Fluticasone as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Fluticasone API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Fluticasone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Fluticasone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Fluticasone NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Fluticasone suppliers with NDC on PharmaCompass.

    Fluticasone GMP

    Fluticasone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Fluticasone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fluticasone GMP manufacturer or Fluticasone GMP API supplier for your needs.

    Fluticasone CoA

    A Fluticasone CoA (Certificate of Analysis) is a formal document that attests to Fluticasone's compliance with Fluticasone specifications and serves as a tool for batch-level quality control.

    Fluticasone CoA mostly includes findings from lab analyses of a specific batch. For each Fluticasone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Fluticasone may be tested according to a variety of international standards, such as European Pharmacopoeia (Fluticasone EP), Fluticasone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fluticasone USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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