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Chemistry

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Also known as: Luvox, 61718-82-9, Fevarin, Faverin, Luvox cr, Du23000
Molecular Formula
C19H25F3N2O6
Molecular Weight
434.4  g/mol
InChI Key
LFMYNZPAVPMEGP-PIDGMYBPSA-N
FDA UNII
5LGN83G74V

Fluvoxamine
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
1 2D Structure

Fluvoxamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
2.1.2 InChI
InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
2.1.3 InChI Key
LFMYNZPAVPMEGP-PIDGMYBPSA-N
2.1.4 Canonical SMILES
COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
5LGN83G74V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Desiflu

2. Du 23000

3. Du-23000

4. Du23000

5. Dumirox

6. Faverin

7. Fevarin

8. Floxyfral

9. Fluvoxadura

10. Fluvoxamin Al

11. Fluvoxamin Beta

12. Fluvoxamin Neuraxpharm

13. Fluvoxamin Ratiopharm

14. Fluvoxamin Stada

15. Fluvoxamin-neuraxpharm

16. Fluvoxamin-ratiopharm

17. Fluvoxamina Geminis

18. Fluvoxamine

19. Fluvoxamine Maleate, (e)-isomer

20. Fluvoxamine, (z)-isomer

21. Geminis, Fluvoxamina

22. Luvox

23. Novo Fluvoxamine

24. Novo-fluvoxamine

25. Nu Fluvoxamine

26. Nu-fluvoxamine

27. Pms Fluvoxamine

28. Pms-fluvoxamine

29. Ratio Fluvoxamine

30. Ratio-fluvoxamine

2.3.2 Depositor-Supplied Synonyms

1. Luvox

2. 61718-82-9

3. Fevarin

4. Faverin

5. Luvox Cr

6. Du23000

7. Fluvoxamine (maleate)

8. Du-23000

9. Fluvoxamine Hydrogenmaleate

10. 54739-20-7

11. Nsc-759602

12. 5lgn83g74v

13. (z)-but-2-enedioic Acid;2-[(e)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine

14. 1-pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, O-(2-aminoethyl)oxime, (e)-, (z)-2-butenedioate (1:1)

15. Fluvoxaminemaleate

16. Floxyfral

17. (e)-5-methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-(2-aminoethyl) Oxime Maleate

18. Mk-264

19. (e)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-o-(2-aminoethyl)oxime Maleate

20. Fluvoxamine Maleate [usan]

21. (2z)-but-2-enedioic Acid; (e)-(2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine

22. Smr000466268

23. Smr000653482

24. Sr-01000075613

25. Sme 3110

26. Unii-5lgn83g74v

27. Depromel

28. Fluvoxamine Maleate [usan:usp]

29. Luvox (tn)

30. Nsc 309469

31. Fluvoxamine Maleate, Solid

32. 5-methoxy-4'-trifluoromethylvalerophenone (e)-o-2-aminoethyloxime Monomaleate

33. Fluvoxamine Maleate- Bio-x

34. 5-methoxy-4'-(trifluoromethyl)valerophenone (e)-o-(2-aminoethyl)oxime, Maleate (1:1)

35. Chembl1409

36. Schembl35225

37. Mls000028469

38. Mls000758271

39. Mls001076285

40. Mls001304717

41. Mls001401391

42. Chebi:5139

43. Dtxsid3042558

44. Fluvoxamine Maleate [mi]

45. Hy-b0103a

46. Fluvoxamine Maleate [jan]

47. Fluvoxamine Maleate (jp17/usp)

48. Hms1571g11

49. Hms2098g11

50. Hms3261d11

51. Hms3412a13

52. Hms3676a13

53. Hms3715g11

54. Hms3884k11

55. Pharmakon1600-01505604

56. Fluvoxamine Maleate [vandf]

57. (2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine; But-2-enedioic Acid

58. Fluvoxamine Maleate [mart.]

59. Sme-3110

60. Tox21_500495

61. Fluvoxamine Maleate [usp-rs]

62. Fluvoxamine Maleate [who-dd]

63. Mfcd00269809

64. Nsc309469

65. Nsc759602

66. S1336

67. Akos015961142

68. Ac-9541

69. Ccg-213494

70. Cs-1839

71. Nsc 759602

72. Nsc-309469

73. Fluvoxamine Maleate [orange Book]

74. Ncgc00093897-01

75. Ncgc00093897-02

76. Ncgc00261180-01

77. (e)-5-methoxy-1-(4-(trifluoromethyl)phenyl)-1-pentanone O-(2-aminoethyl)oxime (z)-2-butenedioate (1:1)

78. As-11790

79. Bf164482

80. Fluvoxamine Maleate [ep Monograph]

81. Smr000058449

82. Fluvoxamine Maleate [usp Monograph]

83. Eu-0100495

84. F0858

85. D00824

86. F 2802

87. 739f183

88. A833394

89. Sr-01000075613-1

90. Sr-01000075613-3

91. Sr-01000075613-4

92. Sr-01000075613-6

93. Fluvoxamine Maleate, British Pharmacopoeia (bp) Reference Standard

94. Fluvoxamine Maleate, European Pharmacopoeia (ep) Reference Standard

95. Fluvoxamine Maleate, United States Pharmacopeia (usp) Reference Standard

96. (e)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime Maleate

97. 5-methoxy-1-(4-trifluoromethyl-phenyl)-pentan-1-one O-(2-amino-ethyl)-oxime Maleate

98. Fluvoxamine For System Suitability, European Pharmacopoeia (ep) Reference Standard

99. Fluvoxamine Maleate, 1.0 Mg/ml In Methanol ((as Free Base)), Certified Reference Material

100. Fluvoxamine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

101. (z)-2-butenedioic Acid; 2-[(e)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine

102. (z)-but-2-enedioic Acid; 2-[(e)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine

103. 1-pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-,o-(2-aminoethyl)oxime, (1e)-, (2z)-2-butenedioate (1:1)

104. 2-[({(1e)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine (2z)-but-2-enedioate

105. 5-methoxy-4'-(trifluoromethyl)valerophenone-(e)-o-(2-aminoethyl)oxime Maleate (1:1)

2.4 Create Date
2006-10-23
3 Chemical and Physical Properties
Molecular Weight 434.4 g/mol
Molecular Formula C19H25F3N2O6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Exact Mass434.16647101 g/mol
Monoisotopic Mass434.16647101 g/mol
Topological Polar Surface Area131 Ų
Heavy Atom Count30
Formal Charge0
Complexity446
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameFluvoxamine maleate
PubMed HealthFluvoxamine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelFluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to a new chemical series, the 2-aminoethyl oxime ethers of aralkylketones. It is chemically unrelated to other SSRIs and clomipramine. It is chemically designated...
Active IngredientFluvoxamine maleate
Dosage FormTablet; Capsule, extended release
RouteOral
Strength25mg; 150mg; 100mg; 50mg
Market StatusPrescription
CompanyAnchen Pharms; Teva; Apotex; Sandoz; Actavis Elizabeth; Mylan; Barr

2 of 6  
Drug NameLuvox
PubMed HealthFluvoxamine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelFluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to a new chemical series, the 2-aminoethyl oxime ethers of aralkylketones. It is chemically unrelated to other SSRIs and clomipramine. It is chemically designated...
Active IngredientFluvoxamine maleate
Dosage FormTablet
Routeoral; Oral
Strength25mg; 100mg; 50mg
Market StatusPrescription
CompanyAni Pharms; Jazz

3 of 6  
Drug NameLuvox cr
Drug LabelLUVOX CR is an extended-release capsule for oral administration that contains fluvoxamine maleate, a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to the chemical series, the 2-aminoethyl oxime ethers of aralkylketones....
Active IngredientFluvoxamine maleate
Dosage FormCapsule, extended release
RouteOral
Strength150mg; 100mg
Market StatusPrescription
CompanyJazz Pharms

4 of 6  
Drug NameFluvoxamine maleate
PubMed HealthFluvoxamine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelFluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to a new chemical series, the 2-aminoethyl oxime ethers of aralkylketones. It is chemically unrelated to other SSRIs and clomipramine. It is chemically designated...
Active IngredientFluvoxamine maleate
Dosage FormTablet; Capsule, extended release
RouteOral
Strength25mg; 150mg; 100mg; 50mg
Market StatusPrescription
CompanyAnchen Pharms; Teva; Apotex; Sandoz; Actavis Elizabeth; Mylan; Barr

5 of 6  
Drug NameLuvox
PubMed HealthFluvoxamine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelFluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to a new chemical series, the 2-aminoethyl oxime ethers of aralkylketones. It is chemically unrelated to other SSRIs and clomipramine. It is chemically designated...
Active IngredientFluvoxamine maleate
Dosage FormTablet
Routeoral; Oral
Strength25mg; 100mg; 50mg
Market StatusPrescription
CompanyAni Pharms; Jazz

6 of 6  
Drug NameLuvox cr
Drug LabelLUVOX CR is an extended-release capsule for oral administration that contains fluvoxamine maleate, a selective serotonin (5-HT) reuptake inhibitor (SSRI) belonging to the chemical series, the 2-aminoethyl oxime ethers of aralkylketones....
Active IngredientFluvoxamine maleate
Dosage FormCapsule, extended release
RouteOral
Strength150mg; 100mg
Market StatusPrescription
CompanyJazz Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)


Cytochrome P-450 CYP1A2 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)


Cytochrome P-450 CYP2C19 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19. (See all compounds classified as Cytochrome P-450 CYP2C19 Inhibitors.)


Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Serotonin Uptake Inhibitors [MoA]; Serotonin Reuptake Inhibitor [EPC]

API Reference Price

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TAINAN CITY 70042 ., , TAIWAN TAIWAN","customerAddress":"5TH FLOOR,LAXMINARAYAN COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720549800,"product":"FLUVOXAMINE MALEATE USP BATCH NO : 610513","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"ENDO OPERATIONS (GX\/SI SUPPLY)","supplierCountry":"UNITED STATES","foreign_port":"LOS ANGELES","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"334.00","actualQuantity":"334","unit":"KGS","unitRateFc":"480","totalValueFC":"162507.8","currency":"USD","unitRateINR":"40671.3","date":"10-Jul-2024","totalValueINR":"13584204.75","totalValueInUsd":"162507.8","indian_port":"Madras Air","hs_no":"29349990","bill_no":"4425884","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"LOS ANGELES","supplierAddress":"1ST FLOOR MINERVA HOUSESIM MONS COURTS ROADBALLS BRIDGE, DUBLIN 4 IRELAND","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721586600,"product":"FLUVOXAMINE MALEATE USP (RE-IMP)(EXP VIDE SB NO.7807100\/28.01.2022)","address":"TYPE-C,PLOT NO.10,ROAD NO.8","city":"HYD-A.P.","supplier":"APOTEX INC","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"SRINI PHARMACEUTICALS","customerCountry":"INDIA","quantity":"106.22","actualQuantity":"106.22","unit":"KGS","unitRateFc":"475","totalValueFC":"51884.6","currency":"USD","unitRateINR":"40831.2","date":"22-Jul-2024","totalValueINR":"4337090.59","totalValueInUsd":"51884.6","indian_port":"Hyderabad Air","hs_no":"29280090","bill_no":"4643523","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"TORONTO","supplierAddress":"50 STEINWAY DRIVE ETOBICOKE-ONTARIOCANADA MSW 6Y3SDNF Canada","customerAddress":"TYPE-C,PLOT NO.10,ROAD NO.8"}]
02-Jan-2021
21-Oct-2024
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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22033

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 150...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22033

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