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1. Bravelle
2. Fertinex
3. Follicle Stimulating Hormone, Human Urine
4. Follicle-stimulating Hormone, Human Urine
5. Follitrin
6. High Purity, Metrodin
7. Human Fsh, Urinary
8. Metrodin
9. Metrodin High Purity
10. Metrodin Hp
11. Neo Fertinorm
12. Urinary Human Fsh
1. 97048-13-0
2. 146479-72-3
3. 1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-n-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
4. Fertinex; Fertinorm; Metrodin; Orgafol; Urofollitrophin
5. 26995-91-5
6. Schembl19712185
7. Dtxsid10869286
8. Q4006490
9. 1-{19-amino-7-(2-amino-2-oxoethyl)-13-(butan-2-yl)-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl}prolylleucylglycinamide
| Molecular Weight | 980.2 g/mol |
|---|---|
| Molecular Formula | C42H65N11O12S2 |
| XLogP3 | -1.5 |
| Hydrogen Bond Donor Count | 12 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 15 |
| Exact Mass | 979.42555890 g/mol |
| Monoisotopic Mass | 979.42555890 g/mol |
| Topological Polar Surface Area | 427 Ų |
| Heavy Atom Count | 67 |
| Formal Charge | 0 |
| Complexity | 1790 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 10 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For treatment of female infertility
FDA Label
Treatment of hypogonadotrophic hypogonadism, Treatment of female infertility
Used for the treatment of female infertility, urofollitropin or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of urofollitropin is the primary hormone responsible for follicular recruitment and development.
G - Genito urinary system and sex hormones
G03 - Sex hormones and modulators of the genital system
G03G - Gonadotropins and other ovulation stimulants
G03GA - Gonadotropins
G03GA04 - Urofollitropin
Absorption
74%
Route of Elimination
Via liver and kidneys
Volume of Distribution
Time to peak in plasma: IM: 17 hours (single dose), 11 hours (multiple doses) SubQ: 21 hours (single dose), 10 hours (multiple doses)
Circulation half life of 3-4 hours, elimination half life of 35-40 hours
FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
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PharmaCompass offers a list of Follistim API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Follistim manufacturer or Follistim supplier for your needs.
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A Follistim manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Follistim, including repackagers and relabelers. The FDA regulates Follistim manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Follistim API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Follistim supplier is an individual or a company that provides Follistim active pharmaceutical ingredient (API) or Follistim finished formulations upon request. The Follistim suppliers may include Follistim API manufacturers, exporters, distributors and traders.
Follistim Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Follistim GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Follistim GMP manufacturer or Follistim GMP API supplier for your needs.
A Follistim CoA (Certificate of Analysis) is a formal document that attests to Follistim's compliance with Follistim specifications and serves as a tool for batch-level quality control.
Follistim CoA mostly includes findings from lab analyses of a specific batch. For each Follistim CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Follistim may be tested according to a variety of international standards, such as European Pharmacopoeia (Follistim EP), Follistim JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Follistim USP).
