Find Fordine manufacturers, exporters & distributors on PharmaCompass

Fordine

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 3 USDMF, 1 NDC API, 1 Listed Suppliers

4 API Suppliers
3 USDMF
1 NDC API
1 Listed Suppliers

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

MARKET PLACE

1 APIs

marketPlace
1 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Huperzine a, 120786-18-7, ( inverted exclamation marka)-huperzine a, Fordine, Huperizine a, (-)-huperzine a

Molecular Formula

C₁₅H₁₈N₂O

Molecular Weight

242.32 g/mol

InChI Key

ZRJBHWIHUMBLCN-QDEBKDIKSA-N

(13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0,]trideca-2,4,6,10-tetraen-5-ol is a natural product found in Streptomyces coelicoflavus and Huperzia with data available.

1 2D Structure

Fordine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one

2.1.2 InChI

InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+

2.1.3 InChI Key

ZRJBHWIHUMBLCN-QDEBKDIKSA-N

2.1.4 Canonical SMILES

CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

2.1.5 Isomeric SMILES

C/C=C/1\C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Huperzine A

2. Huperzine A, (5alpha,9beta,11z)-(-)-isomer

3. Fordine

2.2.2 Depositor-Supplied Synonyms

1. Huperzine A

2. 120786-18-7

3. ( Inverted Exclamation Marka)-huperzine A

4. Fordine

5. Huperizine A

6. (-)-huperzine A

7. (+)-huperzine A

8. (-)-huperzine A (hupa)

9. Huperzinea

10. Ncgc00159362-02

11. 102518-79-6

12. (?)-huperazine A

13. Schembl679315

14. Chembl394259

15. Schembl1047469

16. Chebi:91724

17. Huperzine A [(-)-huperzine A]

18. Dtxsid801115670

19. Hms1362i05

20. Hms1792i05

21. Hms3403i05

22. 103735-86-0

23. Akos022661860

24. Akos026750633

25. Cs-1089

26. Ncgc00163246-02

27. Ncgc00163246-03

28. 5,9-methanocycloocta(b)pyridin-2(1h)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-

29. As-75811

30. Hy-17388

31. (+/-)-huperzine A, Synthetic, >=98% (tlc)

32. Brd-a47065382-001-02-9

33. (11e)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1h)-one

34. (13e)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5,10-tetraen-5-ol

35. (afae'a Centa' Nota Inverted Exclamation Markafasa'a Inverted Exclamation Markafae'adaggeratrade Markafa Centa Centa' Nota Inverted Exclamation Marka'a Not)-huperzine A

2.3 Create Date

2005-09-10

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₈N₂O
Molecular Weight	242.32 g/mol
XLogP3	0
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	242.141913202 g/mol
Monoisotopic Mass	242.141913202 g/mol
Topological Polar Surface Area	55.1 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	551
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

Neuroprotective Agents

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

API SUPPLIERS