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Chemistry

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Also known as: P140 peptide, Unii-1jrb6ukg4q, Forigerimod [usan:inn], 1jrb6ukg4q, Spliceosomal peptide p140, Cep 33457
Molecular Formula
C117H181N34O32PS
Molecular Weight
2638.9  g/mol
InChI Key
LSLBZWAEEUGETG-GGVFYUGVSA-N

Forigerimod
Forigerimod is under investigation for the treatment of Lupus Erythematosus, Systemic.
1 2D Structure

Forigerimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S)-4-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[2-[[(2S,5S)-5-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-8-carbamimidamido-3,4-dioxo-2-(phosphonoamino)octoxy]amino]acetyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-5-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C117H181N34O32PS/c1-9-64(5)94(148-99(163)75(120)24-18-47-128-115(121)122)112(176)144-85(56-71-57-127-62-132-71)106(170)139-80(44-51-185-8)103(167)147-93(63(3)4)110(174)143-83(54-69-32-38-73(154)39-33-69)105(169)146-87(60-152)108(172)138-78(25-14-16-45-118)101(165)137-76(27-19-48-129-116(123)124)96(160)97(161)88(150-184(180,181)182)61-183-133-59-91(157)135-81(26-15-17-46-119)113(177)151-50-21-29-89(151)109(173)140-77(28-20-49-130-117(125)126)100(164)131-58-90(156)136-82(53-68-30-36-72(153)37-31-68)104(168)134-66(7)98(162)142-84(52-67-22-12-11-13-23-67)107(171)149-95(65(6)10-2)111(175)141-79(42-43-92(158)159)102(166)145-86(114(178)179)55-70-34-40-74(155)41-35-70/h11-13,22-23,30-41,57,62-66,75-89,93-95,133,152-155H,9-10,14-21,24-29,42-56,58-61,118-120H2,1-8H3,(H,127,132)(H,131,164)(H,134,168)(H,135,157)(H,136,156)(H,137,165)(H,138,172)(H,139,170)(H,140,173)(H,141,175)(H,142,162)(H,143,174)(H,144,176)(H,145,166)(H,146,169)(H,147,167)(H,148,163)(H,149,171)(H,158,159)(H,178,179)(H4,121,122,128)(H4,123,124,129)(H4,125,126,130)(H3,150,180,181,182)/t64-,65-,66-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,93-,94-,95-/m0/s1
2.1.3 InChI Key
LSLBZWAEEUGETG-GGVFYUGVSA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)C(=O)C(CONCC(=O)NC(CCCCN)C(=O)N3CCCC3C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(C(C)CC)C(=O)NC(CCC(=O)O)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)O)NP(=O)(O)O)NC(=O)C(CCCNC(=N)N)N
2.1.5 Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C(=O)[C@H](CONCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)O)NP(=O)(O)O)NC(=O)[C@H](CCCNC(=N)N)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ipp-201101

2. Lupuzor

3. P140 Peptide

4. Spliceosomal Peptide P140

2.2.2 Depositor-Supplied Synonyms

1. P140 Peptide

2. Unii-1jrb6ukg4q

3. Forigerimod [usan:inn]

4. 1jrb6ukg4q

5. Spliceosomal Peptide P140

6. Cep 33457

7. L-tyrosine, L-arginyl-l-isoleucyl-l-histidyl-l-methionyl-l-valyl-l-tyrosyl-l-seryl-l-lysyl-l- Arginyl-o-phosphono-l-serylglycyl-l-lysyl-l-prolyl-l-arginylglycyl-l-tyrosyl-l-alanyl-l- Phenylalanyl-l-isoleucyl-l-alpha-glutamyl-

8. O(sup 3,140)-phosphono(human U1 Small Nuclear Ribonucleoprotein 70 Kda (snrnp70))-(131- 151)-peptide

2.3 Create Date
2012-03-21
3 Chemical and Physical Properties
Molecular Weight 2638.9 g/mol
Molecular Formula C117H181N34O32PS
XLogP3-10.4
Hydrogen Bond Donor Count40
Hydrogen Bond Acceptor Count42
Rotatable Bond Count90
Exact Mass2638.3073027 g/mol
Monoisotopic Mass2637.3039479 g/mol
Topological Polar Surface Area1110 Ų
Heavy Atom Count185
Formal Charge0
Complexity5690
Isotope Atom Count0
Defined Atom Stereocenter Count21
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 497156-60-2 / Forigerimod API manufacturers, exporters & distributors?

Forigerimod manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Forigerimod API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Forigerimod manufacturer or Forigerimod supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Forigerimod manufacturer or Forigerimod supplier.

PharmaCompass also assists you with knowing the Forigerimod API Price utilized in the formulation of products. Forigerimod API Price is not always fixed or binding as the Forigerimod Price is obtained through a variety of data sources. The Forigerimod Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Forigerimod

Synonyms

P140 peptide, Unii-1jrb6ukg4q, Forigerimod [usan:inn], 1jrb6ukg4q, Spliceosomal peptide p140, Cep 33457

Cas Number

497156-60-2

About Forigerimod

Forigerimod is under investigation for the treatment of Lupus Erythematosus, Systemic.

Forigerimod Manufacturers

A Forigerimod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Forigerimod, including repackagers and relabelers. The FDA regulates Forigerimod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Forigerimod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Forigerimod Suppliers

A Forigerimod supplier is an individual or a company that provides Forigerimod active pharmaceutical ingredient (API) or Forigerimod finished formulations upon request. The Forigerimod suppliers may include Forigerimod API manufacturers, exporters, distributors and traders.

Forigerimod GMP

Forigerimod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Forigerimod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Forigerimod GMP manufacturer or Forigerimod GMP API supplier for your needs.

Forigerimod CoA

A Forigerimod CoA (Certificate of Analysis) is a formal document that attests to Forigerimod's compliance with Forigerimod specifications and serves as a tool for batch-level quality control.

Forigerimod CoA mostly includes findings from lab analyses of a specific batch. For each Forigerimod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Forigerimod may be tested according to a variety of international standards, such as European Pharmacopoeia (Forigerimod EP), Forigerimod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Forigerimod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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