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Chemistry

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Also known as: Diethylstilbestrol diphosphate, 522-40-7, Phosphestrol, Honvan, Stilbestrol diphosphate, Phosphoestrolum
Molecular Formula
C18H22O8P2
Molecular Weight
428.3  g/mol
InChI Key
NLORYLAYLIXTID-ISLYRVAYSA-N
FDA UNII
A0E0NMA80F

Fosfestrol
Fosfestrol is the diphosphate ester of a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
1 2D Structure

Fosfestrol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[(E)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] dihydrogen phosphate
2.1.2 InChI
InChI=1S/C18H22O8P2/c1-3-17(13-5-9-15(10-6-13)25-27(19,20)21)18(4-2)14-7-11-16(12-8-14)26-28(22,23)24/h5-12H,3-4H2,1-2H3,(H2,19,20,21)(H2,22,23,24)/b18-17+
2.1.3 InChI Key
NLORYLAYLIXTID-ISLYRVAYSA-N
2.1.4 Canonical SMILES
CCC(=C(CC)C1=CC=C(C=C1)OP(=O)(O)O)C2=CC=C(C=C2)OP(=O)(O)O
2.1.5 Isomeric SMILES
CC/C(=C(/CC)\C1=CC=C(C=C1)OP(=O)(O)O)/C2=CC=C(C=C2)OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
A0E0NMA80F
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Diethyldioxystilbene Diphosphate

2. Diethylstilbestrol Diphosphate

3. Difostilben

4. Fosfesterol

5. Fosfestrol, (e)-isomer

6. Fosfestrol, 99tc-labeled Cpd

7. Fosfestrol, Disodium Salt, (e)-isomer

8. Fosfestrol, Sodium Salt, (e)-isomer

9. Fosfestrol, Tetrasodium Salt, (e)-isomer

10. Fostestrolum

11. Fostrolin

12. Honvan

13. Kyorin

14. St-52

15. Stilbestrol Diphosphate

16. Stilphostrol

2.3.2 Depositor-Supplied Synonyms

1. Diethylstilbestrol Diphosphate

2. 522-40-7

3. Phosphestrol

4. Honvan

5. Stilbestrol Diphosphate

6. Phosphoestrolum

7. (e)-hex-3-ene-3,4-diylbis(4,1-phenylene) Bis(dihydrogen Phosphate)

8. Fosfestrol [inn]

9. A0e0nma80f

10. [4-[(e)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] Dihydrogen Phosphate

11. Chebi:4532

12. Diethylstilbestrol Diphosphate [usp]

13. Ncgc00181335-01

14. Desdp

15. St52-asta

16. Stilphostrol (tn)

17. Diethylstilbestryl Diphosphate

18. Diethylstilbesterol Diphosphate

19. Fosfestrolum

20. Diethylstilbestrol Diphosphate (usp)

21. Fosfestrolum [inn-latin]

22. Ccris 2778

23. Einecs 208-328-8

24. Unii-a0e0nma80f

25. Phenol, 4,4'-((1e)-1,2-diethyl-1,2-ethenediyl)bis-, Bis(dihydrogen Phosphate)

26. Phenol, 4,4'-[(1e)-1,2-diethyl-1,2-ethenediyl]bis-, Bis(dihydrogen Phosphate)

27. 13425-53-1

28. Fosfestrol [mi]

29. Fosfestrol (jan/inn)

30. Fosfestrol [jan]

31. Alpha,alpha'-diethyl-(e)-4,4'-stilbenediol Bis(dihydrogen Phosphate)

32. Fosfestrol [mart.]

33. Schembl9370

34. Dsstox_cid_26906

35. Dsstox_rid_82005

36. Fosfestrol [who-dd]

37. Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, Bis(dihydrogen Phosphate), (e)-

38. Dsstox_gsid_46906

39. Diethylstilbestrol Bisphosphate

40. Chembl1200598

41. Dtxsid3046906

42. (e)-4,4'-(hex-3-ene-3,4-diyl)bis(4,1-phenylene) Bis(dihydrogen Phosphate)

43. 3-hexene-3,4-diylbis(4,1-phenylene) Bis[dihydrogen (phosphate)]

44. Zinc1531012

45. Tox21_112794

46. 4,4'-stilbenediol, Alpha,alpha'-diethyl-, Bis(dihydrogen Phosphate), (e)-

47. Akos005267157

48. Cas-522-40-7

49. 3,4-bis[p-(phosphonooxy)phenyl]-3-hexene

50. Bb 0266147

51. Diethylstilbestrol Diphosphate [vandf]

52. C08145

53. D00946

54. Sr-01000945066

55. Diethylstilbestrol Diphosphate [orange Book]

56. Q1003185

57. Sr-01000945066-1

58. .alpha.,.alpha.'-diethyl-(e)-4,4'-stilbenediol Bis(dihydrogen Phosphate)

59. [4-[(e)-1-ethyl-2-(4-phosphonooxyphenyl)but-1-enyl]phenyl] Dihydrogen Phosphate

60. 4-{1-ethyl-2-[4-(phosphonooxy)phenyl]-1-butenyl}phenyl Dihydrogen Phosphate

61. Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, Bis(dihydrogen Phosphate), (e)

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 428.3 g/mol
Molecular Formula C18H22O8P2
XLogP32.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass428.07899165 g/mol
Monoisotopic Mass428.07899165 g/mol
Topological Polar Surface Area134 Ų
Heavy Atom Count28
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Hormonal

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)


4.2 ATC Code

L - Antineoplastic and immunomodulating agents

L02 - Endocrine therapy

L02A - Hormones and related agents

L02AA - Estrogens

L02AA04 - Fosfestrol


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Looking for 522-40-7 / Fosfestrol API manufacturers, exporters & distributors?

Fosfestrol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Fosfestrol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fosfestrol manufacturer or Fosfestrol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fosfestrol manufacturer or Fosfestrol supplier.

PharmaCompass also assists you with knowing the Fosfestrol API Price utilized in the formulation of products. Fosfestrol API Price is not always fixed or binding as the Fosfestrol Price is obtained through a variety of data sources. The Fosfestrol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Fosfestrol

Synonyms

Diethylstilbestrol diphosphate, 522-40-7, Phosphestrol, Honvan, Stilbestrol diphosphate, Phosphoestrolum

Cas Number

522-40-7

Unique Ingredient Identifier (UNII)

A0E0NMA80F

About Fosfestrol

Fosfestrol is the diphosphate ester of a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.

Fosfestrol Manufacturers

A Fosfestrol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fosfestrol, including repackagers and relabelers. The FDA regulates Fosfestrol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fosfestrol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fosfestrol Suppliers

A Fosfestrol supplier is an individual or a company that provides Fosfestrol active pharmaceutical ingredient (API) or Fosfestrol finished formulations upon request. The Fosfestrol suppliers may include Fosfestrol API manufacturers, exporters, distributors and traders.

Fosfestrol GMP

Fosfestrol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fosfestrol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fosfestrol GMP manufacturer or Fosfestrol GMP API supplier for your needs.

Fosfestrol CoA

A Fosfestrol CoA (Certificate of Analysis) is a formal document that attests to Fosfestrol's compliance with Fosfestrol specifications and serves as a tool for batch-level quality control.

Fosfestrol CoA mostly includes findings from lab analyses of a specific batch. For each Fosfestrol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fosfestrol may be tested according to a variety of international standards, such as European Pharmacopoeia (Fosfestrol EP), Fosfestrol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fosfestrol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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