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    Chemistry

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    Also known as: Fosinopril sodium, 88889-14-9, Chebi:5164, 1217528-56-7, Dynacil, Eliten
    Molecular Formula
    C30H45NNaO7P
    Molecular Weight
    585.6  g/mol
    InChI Key
    TVTJZMHAIQQZTL-HREVRLCXSA-M
    Fosinopril
    A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.
    1 2D Structure

    Fosinopril

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate
    2.1.2 InChI
    InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30?,39?;/m1./s1
    2.1.3 InChI Key
    TVTJZMHAIQQZTL-HREVRLCXSA-M
    2.1.4 Canonical SMILES
    CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)[O-])C3CCCCC3.[Na+]
    2.1.5 Isomeric SMILES
    CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)[O-])C3CCCCC3.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Dynacil

    2. Fosenopril

    3. Fosinil

    4. Fosinopril

    5. Fosinopril Sodium

    6. Fosinopril, (1(s*(r*)),2 Alpha,4 Alpha)-(d-pro)-isomer

    7. Fosinopril, (1(s*(r*)),2 Alpha,4 Beta)-isomer

    8. Fosinopril, (1(s*(s*)),2 Alpha,4 Beta)-isomer

    9. Fosinorm

    10. Fositens

    11. Fozitec

    12. Hiperlex

    13. Monopril

    14. Newace

    15. Sodium, Fosinopril

    16. Sq 28,555

    17. Sq 28555

    18. Sq-28,555

    19. Sq-28555

    20. Sq28,555

    21. Sq28555

    22. Staril

    23. Tenso Stop

    24. Tensocardil

    2.2.2 Depositor-Supplied Synonyms

    1. Fosinopril Sodium

    2. 88889-14-9

    3. Chebi:5164

    4. 1217528-56-7

    5. Dynacil

    6. Eliten

    7. Sodium;(2s,4s)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate

    8. Sodium (2s,4s)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylate

    9. Fosinopril Sodium- Bio-x

    10. Ncgc00167432-01

    11. Dsstox_cid_26621

    12. Dsstox_rid_81772

    13. Dsstox_gsid_46621

    14. Schembl40690

    15. Chembl3188382

    16. Dtxsid7046621

    17. Tox21_112436

    18. Mfcd00897699

    19. Akos015888700

    20. Ac-6227

    21. Bcp9000703

    22. Bs-1003

    23. Sq28555

    24. Bf164489

    25. Cas-88889-14-9

    26. A842989

    27. Sodium (2s,4s)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate

    28. Sodium (2s,4s)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-

    29. Sodium (2s,4s)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)-(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylate

    30. Sodium (2s,4s)-4-cyclohexyl-1-(2-{[2-methyl-1-(propionyloxy) Propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate

    31. Sodium(2s,4s)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylate

    2.3 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 585.6 g/mol
    Molecular Formula C30H45NNaO7P
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count15
    Exact Mass585.28313405 g/mol
    Monoisotopic Mass585.28313405 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count40
    Formal Charge0
    Complexity857
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFosinopril sodium
    Drug LabelFosinopril sodium tablet, USP is the sodium salt of fosinopril USP, the ester prodrug of an angiotensin converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin con...
    Active IngredientFosinopril sodium
    Dosage FormTablet
    RouteOral
    Strength10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyActavis Labs Fl; Teva; Apotex; Aurobindo Pharma; Sandoz; Invagen Pharms

    2 of 2  
    Drug NameFosinopril sodium
    Drug LabelFosinopril sodium tablet, USP is the sodium salt of fosinopril USP, the ester prodrug of an angiotensin converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin con...
    Active IngredientFosinopril sodium
    Dosage FormTablet
    RouteOral
    Strength10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyActavis Labs Fl; Teva; Apotex; Aurobindo Pharma; Sandoz; Invagen Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Angiotensin-Converting Enzyme Inhibitors

    A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Angiotensin-converting Enzyme Inhibitors [MoA]; Angiotensin Converting Enzyme Inhibitor [EPC]

    API Reference Price

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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00008","unit":"KGS","unitRateFc":"7617000","totalValueFC":"627.2","currency":"USD","unitRateINR":"611592500","date":"18-Jun-2022","totalValueINR":"48927.4","totalValueInUsd":"627.2","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"9166190","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655490600,"product":"FOSINOPRIL RELATED COMPOUND F(QTY: 1X0.2 GMS,PRICE: USD 1509.81)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655490600,"product":"FOSINOPRIL RELATED COMPOUND F(QTY: 2X15 MG,PRICE: USD 806\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00003","unit":"KGS","unitRateFc":"53733333.3","totalValueFC":"1659.1","currency":"USD","unitRateINR":"4314416000","date":"18-Jun-2022","totalValueINR":"129432.48","totalValueInUsd":"1659.1","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"9166190","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0002","unit":"KGS","unitRateFc":"1285000","totalValueFC":"264.5","currency":"USD","unitRateINR":"103176650","date":"18-Jun-2022","totalValueINR":"20635.33","totalValueInUsd":"264.5","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"9166190","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668623400,"product":"FOSINOPRIL SODIUM PH.EUR","address":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET","city":"HYDERABAD","supplier":"ZHEJIANG HUAHAI PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"1380","totalValueFC":"35424.6","currency":"USD","unitRateINR":"115644","date":"17-Nov-2022","totalValueINR":"2891100","totalValueInUsd":"35424.6","indian_port":"HYDERABAD AIR","hs_no":"29241900","bill_no":"3345942","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690482600,"product":"FOSINOPRIL SODIUM PH.EUR","address":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET","city":"HYDERABAD","supplier":"ZHEJIANG HUAHAI PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"1380","totalValueFC":"278553.7","currency":"USD","unitRateINR":"114470.9","date":"28-Jul-2023","totalValueINR":"22894200.32","totalValueInUsd":"278553.7","indian_port":"HYDERABAD AIR","hs_no":"29241900","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET"}]
    21-Jan-2021
    11-Sep-2024
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    ABOUT THIS PAGE

    Fosinopril Manufacturers

    A Fosinopril manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fosinopril, including repackagers and relabelers. The FDA regulates Fosinopril manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fosinopril API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Fosinopril manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Fosinopril Suppliers

    A Fosinopril supplier is an individual or a company that provides Fosinopril active pharmaceutical ingredient (API) or Fosinopril finished formulations upon request. The Fosinopril suppliers may include Fosinopril API manufacturers, exporters, distributors and traders.

    click here to find a list of Fosinopril suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Fosinopril USDMF

    A Fosinopril DMF (Drug Master File) is a document detailing the whole manufacturing process of Fosinopril active pharmaceutical ingredient (API) in detail. Different forms of Fosinopril DMFs exist exist since differing nations have different regulations, such as Fosinopril USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Fosinopril DMF submitted to regulatory agencies in the US is known as a USDMF. Fosinopril USDMF includes data on Fosinopril's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fosinopril USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Fosinopril suppliers with USDMF on PharmaCompass.

    Fosinopril CEP

    A Fosinopril CEP of the European Pharmacopoeia monograph is often referred to as a Fosinopril Certificate of Suitability (COS). The purpose of a Fosinopril CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Fosinopril EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Fosinopril to their clients by showing that a Fosinopril CEP has been issued for it. The manufacturer submits a Fosinopril CEP (COS) as part of the market authorization procedure, and it takes on the role of a Fosinopril CEP holder for the record. Additionally, the data presented in the Fosinopril CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Fosinopril DMF.

    A Fosinopril CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Fosinopril CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Fosinopril suppliers with CEP (COS) on PharmaCompass.

    Fosinopril WC

    A Fosinopril written confirmation (Fosinopril WC) is an official document issued by a regulatory agency to a Fosinopril manufacturer, verifying that the manufacturing facility of a Fosinopril active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Fosinopril APIs or Fosinopril finished pharmaceutical products to another nation, regulatory agencies frequently require a Fosinopril WC (written confirmation) as part of the regulatory process.

    click here to find a list of Fosinopril suppliers with Written Confirmation (WC) on PharmaCompass.

    Fosinopril NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Fosinopril as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Fosinopril API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Fosinopril as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Fosinopril and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Fosinopril NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Fosinopril suppliers with NDC on PharmaCompass.

    Fosinopril GMP

    Fosinopril Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Fosinopril GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fosinopril GMP manufacturer or Fosinopril GMP API supplier for your needs.

    Fosinopril CoA

    A Fosinopril CoA (Certificate of Analysis) is a formal document that attests to Fosinopril's compliance with Fosinopril specifications and serves as a tool for batch-level quality control.

    Fosinopril CoA mostly includes findings from lab analyses of a specific batch. For each Fosinopril CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Fosinopril may be tested according to a variety of international standards, such as European Pharmacopoeia (Fosinopril EP), Fosinopril JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fosinopril USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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