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Chemistry

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Also known as: Cvm-1118, Foslinanib [inn], Foslinanib [usan], Trx 818, Trx-818, 2x2dnm7ngx
Molecular Formula
C16H13FNO6P
Molecular Weight
365.25  g/mol
InChI Key
ZDWFMAHQGDEALT-UHFFFAOYSA-N
FDA UNII
2X2DNM7NGX

Foslinanib
Foslinanib is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry activities. Upon oral administration, foslinanib targets and inhibits the formation of vasculogenic mimicry (VM; vascular mimicry). By destroying the VM channels and network, cancer cells are devoid of perfusion leading to an induction of cancer cell apoptosis and inhibition of cancer cell proliferation. VM is associated with tumor metastasis.
1 2D Structure

Foslinanib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[2-(3-fluorophenyl)-6-methoxy-4-oxo-1H-quinolin-5-yl] dihydrogen phosphate
2.1.2 InChI
InChI=1S/C16H13FNO6P/c1-23-14-6-5-11-15(16(14)24-25(20,21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9/h2-8H,1H3,(H,18,19)(H2,20,21,22)
2.1.3 InChI Key
ZDWFMAHQGDEALT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C2=C(C=C1)NC(=CC2=O)C3=CC(=CC=C3)F)OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
2X2DNM7NGX
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl Phosphate

2. Fmod Phosphate

3. Sodium 2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl Phosphate

2.3.2 Depositor-Supplied Synonyms

1. Cvm-1118

2. Foslinanib [inn]

3. Foslinanib [usan]

4. Trx 818

5. Trx-818

6. 2x2dnm7ngx

7. Trx-818 Free Acid

8. Cvm-1118 Free Acid

9. 1256037-60-1

10. 4(1h)-quinolinone, 2-(3-fluorophenyl)-6-methoxy-5-(phosphonooxy)-

11. 2-(3-fluorophenyl)-4-hydroxy-6-methoxyquinolin-5-yl Dihydrogen Phosphate

12. 2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl Dihydrogen Phosphate

13. 2054938-73-5

14. Foslinanib (usan/inn)

15. Foslinanib [usan:inn]

16. Unii-2x2dnm7ngx

17. Foslinanib [who-dd]

18. Schembl339272

19. Chembl1615993

20. Gtpl11621

21. Who 10721

22. D11639

23. 2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl Phosphate

24. [2-(3-fluorophenyl)-6-methoxy-4-oxo-1h-quinolin-5-yl] Dihydrogen Phosphate

2.4 Create Date
2011-01-24
3 Chemical and Physical Properties
Molecular Weight 365.25 g/mol
Molecular Formula C16H13FNO6P
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass365.04645229 g/mol
Monoisotopic Mass365.04645229 g/mol
Topological Polar Surface Area105 Ų
Heavy Atom Count25
Formal Charge0
Complexity593
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Foslinanib Manufacturers

A Foslinanib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Foslinanib, including repackagers and relabelers. The FDA regulates Foslinanib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Foslinanib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Foslinanib Suppliers

A Foslinanib supplier is an individual or a company that provides Foslinanib active pharmaceutical ingredient (API) or Foslinanib finished formulations upon request. The Foslinanib suppliers may include Foslinanib API manufacturers, exporters, distributors and traders.

Foslinanib GMP

Foslinanib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Foslinanib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Foslinanib GMP manufacturer or Foslinanib GMP API supplier for your needs.

Foslinanib CoA

A Foslinanib CoA (Certificate of Analysis) is a formal document that attests to Foslinanib's compliance with Foslinanib specifications and serves as a tool for batch-level quality control.

Foslinanib CoA mostly includes findings from lab analyses of a specific batch. For each Foslinanib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Foslinanib may be tested according to a variety of international standards, such as European Pharmacopoeia (Foslinanib EP), Foslinanib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Foslinanib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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