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Chemistry

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Also known as: Apx001, 2091769-17-2, Fosmanogepix [inn], Fosmanogepix [usan], Apx-001, 1xq871489p
Molecular Formula
C22H21N4O6P
Molecular Weight
468.4  g/mol
InChI Key
JQONJQKKVAHONF-UHFFFAOYSA-N
FDA UNII
1XQ871489P

Fosmanogepix
Fosmanogepix is an orally available small molecule inhibitor of the Gwt1 fungal enzyme with potential antifungal activity. Upon administration, fosmanogepix, a N-phosphonooxymethyl prodrug, is rapidly and completely metabolized by systemic alkaline phosphatases to its active moiety, APX001A (E1210). The active prodrug targets Gwt1, a highly conserved inositol acylase which catalyzes an essential step in the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway. Inhibition of Gwt1 prevents localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth.
1 2D Structure

Fosmanogepix

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[2-amino-3-[3-[[4-(pyridin-2-yloxymethyl)phenyl]methyl]-1,2-oxazol-5-yl]pyridin-1-ium-1-yl]methyl hydrogen phosphate
2.1.2 InChI
InChI=1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)
2.1.3 InChI Key
JQONJQKKVAHONF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C([N+](=CC=C4)COP(=O)(O)[O-])N
2.2 Other Identifiers
2.2.1 UNII
1XQ871489P
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Apx001

2. 2091769-17-2

3. Fosmanogepix [inn]

4. Fosmanogepix [usan]

5. Apx-001

6. 1xq871489p

7. E1211

8. (2-amino-3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-1-ium-1-yl)methyl Hydrogen Phosphate

9. Pyridinium, 2-amino-1-((phosphonooxy)methyl)-3-(3-((4-((2-pyridinyloxy)methyl)phenyl)methyl)-5-isoxazolyl)-, Inner Salt

10. Fosmanogepix (usan/inn)

11. Chembl4297591

12. Schembl22749842

13. Unii-1xq871489p

14. Ex-a5184

15. Who 10818

16. Db15183

17. 1169701-00-1

18. D11694

19. (12-amino-6-oxa-1(3),7(2)-dipyridina-2(5,3)-(1,2)oxazola- 4(1,4)-benzenaheptaphan-11-ium-11-yl)methyl Hydrogen Phosphate

20. (12-amino-6-oxa-1(3),7(2)-dipyridina-2(5,3)-(1,2)oxazola-4(1,4)-benzenaheptaphan-11-ium-11-yl)methyl Hydrogen Phosphate

21. (2-amino-3-(3-((4-(2-pyridyloxymethyl)phenyl)methyl)isoxazol-5-yl)pyridin-1-ium-1-yl)methyl Hydrogen Phosphate

22. [2-amino-3-[3-[[4-(pyridin-2-yloxymethyl)phenyl]methyl]-1,2-oxazol-5-yl]pyridin-1-ium-1-yl]methyl Hydrogen Phosphate

2.4 Create Date
2009-07-27
3 Chemical and Physical Properties
Molecular Weight 468.4 g/mol
Molecular Formula C22H21N4O6P
XLogP31.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass468.11987140 g/mol
Monoisotopic Mass468.11987140 g/mol
Topological Polar Surface Area148 Ų
Heavy Atom Count33
Formal Charge0
Complexity644
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Fosmanogepix Manufacturers

A Fosmanogepix manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fosmanogepix, including repackagers and relabelers. The FDA regulates Fosmanogepix manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fosmanogepix API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fosmanogepix Suppliers

A Fosmanogepix supplier is an individual or a company that provides Fosmanogepix active pharmaceutical ingredient (API) or Fosmanogepix finished formulations upon request. The Fosmanogepix suppliers may include Fosmanogepix API manufacturers, exporters, distributors and traders.

Fosmanogepix GMP

Fosmanogepix Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fosmanogepix GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fosmanogepix GMP manufacturer or Fosmanogepix GMP API supplier for your needs.

Fosmanogepix CoA

A Fosmanogepix CoA (Certificate of Analysis) is a formal document that attests to Fosmanogepix's compliance with Fosmanogepix specifications and serves as a tool for batch-level quality control.

Fosmanogepix CoA mostly includes findings from lab analyses of a specific batch. For each Fosmanogepix CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fosmanogepix may be tested according to a variety of international standards, such as European Pharmacopoeia (Fosmanogepix EP), Fosmanogepix JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fosmanogepix USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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