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Chemistry

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Also known as: 23110-15-8, Fugillin, Fumidil, Amebacilin, Fumagilline, Fumagillinum
Molecular Formula
C26H34O7
Molecular Weight
458.5  g/mol
InChI Key
NGGMYCMLYOUNGM-CSDLUJIJSA-N
FDA UNII
7OW73204U1

Fumagillin
fumagillin is a natural product found in Aspergillus fumigatus with data available.
1 2D Structure

Fumagillin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
2.1.2 InChI
InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
2.1.3 InChI Key
NGGMYCMLYOUNGM-CSDLUJIJSA-N
2.1.4 Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
2.1.5 Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C
2.2 Other Identifiers
2.2.1 UNII
7OW73204U1
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Fumidil B

2.3.2 Depositor-Supplied Synonyms

1. 23110-15-8

2. Fugillin

3. Fumidil

4. Amebacilin

5. Fumagilline

6. Fumagillinum

7. Fumagilina

8. (-)-fumagillin

9. Zgn-201

10. Amebacillin

11. Fugilin

12. Chembl32838

13. 2,4,6,8-decatetraenedioic Acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl Ester

14. Fumagillin Dch

15. Chebi:48635

16. Nsc-9168

17. 7ow73204u1

18. Dsstox_cid_20736

19. Dsstox_rid_79580

20. Dsstox_gsid_40736

21. (2e,4e,6e,8e)-10-({(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic Acid

22. Fumagillina

23. Flisint

24. (2e,4e,6e,8e)-10-(((3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraeno

25. Cas-23110-15-8

26. Fumagillina [dcit]

27. U 5762

28. Fumagilina [inn-spanish]

29. Fumagilline [inn-french]

30. Fumagillinum [inn-latin]

31. Nsc9168

32. Fumagillin [inn:ban:dcf]

33. Ccris 9025

34. Unii-7ow73204u1

35. Ncgc00163699-01

36. H-3

37. Nsc 9168

38. Einecs 245-433-8

39. Fumagillin [mi]

40. Fumagillin [inn]

41. Fumagillin [mart.]

42. Schembl8130

43. Fumagillin [who-dd]

44. Dtxsid7040736

45. Schembl15263952

46. (2e,4e,6e,8e)-mono[(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic Acid Ester

47. Ex-a2890

48. Hy-b0751

49. Zinc4098264

50. Tox21_112066

51. Tox21_302410

52. Bdbm50113436

53. S7784

54. Akos024456768

55. Db02640

56. Lmpr0103060003

57. Ncgc00163699-02

58. Ncgc00163699-07

59. Ncgc00255568-01

60. Ac-35866

61. Bs-16576

62. Sr-90144

63. D81922

64. Q120199

65. (2e,4e,6e,8e)-10-(((3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic Acid

66. 127913-45-5

67. 2,4,6,8-decatetraenedioic Acid, 1-((3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl)-1-oxaspiro(2.5)oct-6-yl) Ester, (2e,4e,6e,8e)-

68. 2,4,6,8-decatetraenedioic Acid, Mono((3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl) Ester, (2e,4e,6e,8e)-

69. 2,4,6,8-decatetraenedioic Acid, Mono(4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2.5)oct-6-yl) Ester

70. 2,4,6,8-decatetraenedioic Acid, Mono(4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2.5)oct-6-yl) Ester (van)

71. 2,4,6,8-decatetraenedioic Acid, Mono(5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl) Ester, (3r- (3.alpha.,4.alpha.(2r*,3r*),5.beta.,6.beta.(2e,4e,6e,8e)))-

72. 2,4,6,8-decatetraenedioic Acid, Mono(5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl) Ester, (3r-(3alp

73. 2,4,6,8-decatetraenedioic Acid, Mono[(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] Ester, (2e,4e,6e,8e)-

74. Antibiotic Obtained From Cultures Of Aspergillus Fumigatus, Or The Same Substance Produced By Any Other Means

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 458.5 g/mol
Molecular Formula C26H34O7
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass458.23045342 g/mol
Monoisotopic Mass458.23045342 g/mol
Topological Polar Surface Area97.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity879
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count4
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)


Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Antiprotozoal Agents

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)


4.2 ATC Code

P - Antiparasitic products, insecticides and repellents

P01 - Antiprotozoals

P01A - Agents against amoebiasis and other protozoal diseases

P01AX - Other agents against amoebiasis and other protozoal diseases

P01AX10 - Fumagillin


API SUPPLIERS

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Shanghai Minbiotech

China

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Shanghai Minbiotech CB

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Zhejiang Huida Biotech

China

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Zhejiang Huida Biotech

China

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CKD Bio Corporation

South Korea

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CKD Bio Corporation

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API Reference Price

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23-Jan-2021
20-Nov-2024
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ABOUT THIS PAGE

Fumagillin Manufacturers

A Fumagillin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fumagillin, including repackagers and relabelers. The FDA regulates Fumagillin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fumagillin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Fumagillin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Fumagillin Suppliers

A Fumagillin supplier is an individual or a company that provides Fumagillin active pharmaceutical ingredient (API) or Fumagillin finished formulations upon request. The Fumagillin suppliers may include Fumagillin API manufacturers, exporters, distributors and traders.

click here to find a list of Fumagillin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Fumagillin GMP

Fumagillin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fumagillin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fumagillin GMP manufacturer or Fumagillin GMP API supplier for your needs.

Fumagillin CoA

A Fumagillin CoA (Certificate of Analysis) is a formal document that attests to Fumagillin's compliance with Fumagillin specifications and serves as a tool for batch-level quality control.

Fumagillin CoA mostly includes findings from lab analyses of a specific batch. For each Fumagillin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fumagillin may be tested according to a variety of international standards, such as European Pharmacopoeia (Fumagillin EP), Fumagillin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fumagillin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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