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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 Listed Suppliers

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1 Drugs in Development

1 Drugs in Development

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1 FDF Dossiers

ANALYTICAL

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1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Furazidin, 1672-88-4, Furazidine, Akritoin, Furaginum, 1-((3-(5-nitro-2-furyl)allylidene)amino)hydantoin

Molecular Formula

C₁₀H₈N₄O₅

Molecular Weight

264.19 g/mol

InChI Key

DECBQELQORZLLP-UAIOPKHMSA-N

FDA UNII

K2R4N34Y9I

Nitrofuran derivative anti-infective agent used for urinary tract infections.

1 2D Structure

Furazidin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione

2.1.2 InChI

InChI=1S/C10H8N4O5/c15-8-6-13(10(16)12-8)11-5-1-2-7-3-4-9(19-7)14(17)18/h1-5H,6H2,(H,12,15,16)/b2-1+,11-5+

2.1.3 InChI Key

DECBQELQORZLLP-UAIOPKHMSA-N

2.1.4 Canonical SMILES

C1C(=O)NC(=O)N1N=CC=CC2=CC=C(O2)[N+](=O)[O-]

2.1.5 Isomeric SMILES

C1C(=O)NC(=O)N1/N=C/C=C/C2=CC=C(O2)[N+](=O)[O-]

2.2 Other Identifiers

2.2.1 UNII

K2R4N34Y9I

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Furazidin

2. Solafur

2.3.2 Depositor-Supplied Synonyms

1. Furazidin

2. 1672-88-4

3. Furazidine

4. Akritoin

5. Furaginum

6. 1-((3-(5-nitro-2-furyl)allylidene)amino)hydantoin

7. 1-[(e)-[(e)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione

8. K2r4n34y9i

9. Nf 416

10. F-35

11. 1-((3-(5-nitro-2-furyl)allylidene)amino)-hydantoin

12. 1-[(e)-[(z)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione

13. Furamag

14. 1-((3-(5-nitrofuran-2-yl)allylidene)-amino)imidazolidine-2,4-dione

15. 1-(((1e,2e)-3-(5-nitrofuran-2-yl)allylidene)amino)imidazolidine-2,4-dione

16. 1-{[(1e,2e)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]amino}imidazolidine-2,4-dione

17. Ccris 1199

18. 1-(3-(5-nitro-2-furyl)-n-2-propenylidine)amino-hydantoin

19. Brn 0307076

20. Unii-k2r4n34y9i

21. Furagin (tn)

22. Furazidin [mart.]

23. Furazidin [who-dd]

24. 1-[3-(5-nitro-2-furyl)allylidenamino]hydantoin

25. 4-24-00-01048 (beilstein Handbook Reference)

26. Schembl3194895

27. Chembl3707254

28. Hydantoin, 1-((3-(5-nitro-2-furyl)allylidene)amino)-

29. Schembl17292896

30. J01xe03

31. Dtxsid101030908

32. Ex-a1974

33. Bdbm50549808

34. S3709

35. Stk368597

36. Zinc31430194

37. 1-((3-(5-nitro-2-furanyl)-2-propenylidene)amino)-4-imidazolidinedione

38. 2,4-imidazolidinedione, 1-((3-(5-nitro-2-furanyl)-2-propenylidene)amino)-

39. Akos005444359

40. Ccg-267084

41. Cs-0798

42. Db13475

43. Bs-49182

44. Hy-77036

45. D07998

46. 672f884

47. A810846

48. 1-(3-(5-nitro-2-furyl)-n-2-propenylidine)aminohydantoin

49. 1-(((e)-3-(5-nitrofuran-2-yl)prop-2-enylidene)amino)imidazolidine-2,4-dione

50. 2,4-imidazolidinedione, 1-[[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]amino]-

2.4 Create Date

2006-07-03

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₈N₄O₅
Molecular Weight	264.19 g/mol
XLogP3	0.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	264.04946937 g/mol
Monoisotopic Mass	264.04946937 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	455
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)

4.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01X - Other antibacterials

J01XE - Nitrofuran derivatives

J01XE03 - Furazidin

API SUPPLIERS

01

Olpha

Latvia

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

SupplySide West 2024

Not Confirmed

Olpha, a JSC AB City subsidiary, is a leading Baltic firm with 50 years of experience in medicines & chemical pharmaceuticals.

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Latvia

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF ASMF

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02

Menadiona

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

SupplySide West 2024

Not Confirmed

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Drugs in Development

01 Olpha

Latvia

SupplySide West 2024

Not Confirmed

Olpha, a JSC AB City subsidiary, is a leading Baltic firm with 50 years of experience in medicines & chemical pharmaceuticals.

Lead Product(s) : Furazidin

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Undisclosed

Deal Type : Agreement

DEALS_DEV

JSC Olainfarm & Adalvo to Launch a New Urology Product in 17 Countries In 2022-2023

Details : In partnership Olainfarm will manage Furagins (Furaginum) regulatory affairs, distribution and promotion in Latvia, Russia, Kazakhstan, Belarus, Ukraine, and other countries and Adalvo will be responsible for development, manufacturing and will support m...

Brand Name : Furagins

Molecule Type : Small molecule

Upfront Cash : Undisclosed

June 16, 2021

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