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Chemistry

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Also known as: Furoxone, Nitrofurazolidone, 67-45-8, Furazolidine, Nitrofuroxon, Furazolidon
Molecular Formula
C8H7N3O5
Molecular Weight
225.16  g/mol
InChI Key
PLHJDBGFXBMTGZ-WEVVVXLNSA-N
FDA UNII
5J9CPU3RE0

Furazolidone
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
1 2D Structure

Furazolidone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
2.1.2 InChI
InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
2.1.3 InChI Key
PLHJDBGFXBMTGZ-WEVVVXLNSA-N
2.1.4 Canonical SMILES
C1COC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
2.1.5 Isomeric SMILES
C1COC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
5J9CPU3RE0
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Furazol

2. Furazolidine

3. Furoxone

4. Nifurazolidone

2.3.2 Depositor-Supplied Synonyms

1. Furoxone

2. Nitrofurazolidone

3. 67-45-8

4. Furazolidine

5. Nitrofuroxon

6. Furazolidon

7. Nifurazolidone

8. Diafuron

9. Furaxone

10. Furazol

11. Furazon

12. Furidon

13. Nitrofurazolidonum

14. Furozolidine

15. Coryzium

16. Furoxane

17. Nifulidone

18. Roptazol

19. Tikofuran

20. Topazone

21. Trichofuron

22. Tricofuron

23. Tricoron

24. Trifurox

25. Furall

26. Furaxon

27. Furoxal

28. Furoxon

29. Giardil

30. Giarlam

31. Medaron

32. Neftin

33. Nicolen

34. Optazol

35. Ortazol

36. Puradin

37. Corizium

38. Enterotoxon

39. Sclaventerol

40. Viofuragyn

41. Bifuron

42. Furovag

43. Nifuran

44. Furox

45. Furoxone Swine Mix

46. Usaf Ea-1

47. 3-(5'-nitrofurfuralamino)-2-oxazolidone

48. N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone

49. Furazolidona

50. Furazolidonum

51. 3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone

52. 2-oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene]amino]-

53. 5-nitro-n-(2-oxo-3-oxazolidinyl)-2-furanmethanimine

54. N-(5-nitro-2-furfurylidene)-3-aminooxazolidine-2-one

55. 3-((5-nitrofurfurylidene)amino)-2-oxazolidinone

56. 3-((5-nitrofurylidene)amino)-2-oxazolidone

57. 3-((5-nitrofurfurylidene)amino)-2-oxazolidone

58. 3-[(e)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one

59. 3-[(5-nitrofurylidene)amino]-2-oxazolidone

60. 3-(((5-nitro-2-furanyl)methylene)amino)-2-oxazolidinone

61. 3-[(5-nitrofurfurylidene)amino]-2-oxazolidone

62. Nf 180 Custom Mix Ten

63. 3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone

64. Nsc-6469

65. 2-furanmethanimine, 5-nitro-n-(2-oxo-3-oxazolidinyl)-

66. Mls000069727

67. 3-{[(5-nitro-2-furanyl)methylene]amino}-2-oxazolidinone

68. 2-oxazolidinone, 3-(((5-nitro-2-furanyl)methylene)amino)-

69. 3-{[(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one

70. Nsc6469

71. 2-oxazolidinone, 3-((5-nitrofurfurylidine)amino)-

72. Nf 180

73. Ncgc00095304-02

74. Smr000058228

75. Dsstox_cid_21997

76. Dsstox_rid_79899

77. Dsstox_gsid_41997

78. 2-oxazolidinone, 3-((5-nitrofurfurylidene)amino)-

79. Fiurox Aerosol Powder

80. 3-(((5-nitrofuran-2-yl)methylene)amino)oxazolidin-2-one

81. Furoxone (tn)

82. 3-((5-nitrofurfurylidine)amino)-2-oxazolidinone

83. 3-[(5-nitrofurfurylidine)amino]-2-oxazolidinone

84. 5j9cpu3re0

85. Sr-05000001632

86. 2-oxazolidinone, 3-[(5-nitrofurfurylidene)amino]-

87. 2-oxazolidinone, 3-[(5-nitrofurfurylidine)amino]-

88. Furazolidone (usp/inn)

89. Chebi:5195

90. Cas-67-45-8

91. Fzl

92. Mfcd00010550

93. Component Of Topazone

94. Component Of Tricofuron

95. Opera_id_256

96. Prestwick2_000808

97. Prestwick3_000808

98. Spectrum5_000742

99. Furazolidone [mi]

100. Furazolidone [inn]

101. F-8900

102. Furazolidone [hsdb]

103. Furazolidone [iarc]

104. Chembl1103

105. Schembl64996

106. Bspbio_000675

107. Bspbio_002052

108. Furazolidone [mart.]

109. Mls001304180

110. Bidd:gt0182

111. Furazolidone [usp-rs]

112. Furazolidone [who-dd]

113. Spectrum1500309

114. Bpbio1_000743

115. Hms500e07

116. 3-[(e)-(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one

117. 3-[[(5-nitro-2-furanyl)methylene]-amino]-2-oxazolidinone

118. Furazolidone [green Book]

119. 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

120. Furazolidone [orange Book]

121. Hms1920o22

122. Hms2091h03

123. Pharmakon1600-01500309

124. Furazolidone [usp Impurity]

125. Hy-b1336

126. Zinc7997571

127. Furazolidone [usp Monograph]

128. Tox21_111502

129. 3-{[(e)-(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one

130. Ccg-40233

131. Nsc757038

132. S4528

133. Stk388219

134. Akos001678302

135. Furazolidone, Vetec(tm) Reagent Grade

136. Tox21_111502_1

137. Ccg-266758

138. Cs-4897

139. Db00614

140. Nsc-757038

141. Furazolidone 100 Microg/ml In Methanol

142. Idi1_000085

143. Wln: T5oj Bnw E1un- At5nvotj

144. Ncgc00095304-01

145. Ncgc00095304-03

146. Ncgc00095304-04

147. Ncgc00095304-05

148. Ncgc00095304-06

149. Ncgc00188974-01

150. Ac-11695

151. Ac-32486

152. Sbi-0051388.p003

153. Ab00443658

154. A16011

155. C07999

156. D00830

157. Ab00052000_03

158. Furazolidone, Vetranal(tm), Analytical Standard

159. A835757

160. Furazolidone, Antibiotic For Culture Media Use Only

161. Sr-05000001632-1

162. Sr-05000001632-3

163. Brd-k10647544-001-02-0

164. Brd-k11756522-001-03-2

165. Brd-k11756522-001-04-0

166. 3-[(e)-(5-nitro-2-furanyl)methylideneamino]-2-oxazolidinone

167. 3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone, 9ci

168. 3-([(5-nitro-2-furyl)methylidene]amino)-1,3-oxazolidin-2-one #

169. 3-{[(1e)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

170. Furazolidone, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2006-01-25
3 Chemical and Physical Properties
Molecular Weight 225.16 g/mol
Molecular Formula C8H7N3O5
XLogP3-0.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass225.03857033 g/mol
Monoisotopic Mass225.03857033 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count16
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Furazolidone is used in the treatment of cholera when anti-infective therapy is indicated as an adjunct to fluid and electrolyte replacement.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 861


Furazolidone is used for the specific and symptomatic treatment of diarrhea and enteritis caused by susceptible bacteria or protozoa.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 861


Furazolidone ... often is prescribed /to treat giardiasis in/ children because the drug is available in a pleasant liquid formulation. ... Furazolidone is the only drug currently approved by the US FDA for treatment of giardiasis.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1098


4.2 Drug Warning

After use of furazolidone as a drug, acute nausea, emesis, occasional diarrhea, abdominal pain and intestinal bleeding were observed; hepatic damage, as evidenced by biochemical tests, and peripheral neuropathy were also seen.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V31 146 (1983)


Nausea and vomiting are the most common side effects of oral furazolidone therapy; abdominal pain and diarrhea occasionally occur. These effects can be minimized or eliminated by reducing dosage or discontinuing the drug.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 861


Hypersensitivity reactions to oral furazolidone have occurred in a small number of patients and generally subside with discontinuance of the drug. Hypersensitivity reactions include a fall in blood pressure, angioedema, fever, arthralgia, urticaria, and a vesicular or morbilliform rash. Erythema multiforme, pulmonary infiltration, and pulmonary eosinophilia also have been reported and may be due to hypersensitivity.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 861


Headache and malaise occur occasionally with oral furazolidone therapy and can be minimized or eliminated by reducing dosage or discontinuing the drug. Following oral furazolidone administration, hypoglycemia, agranulocytosis, and, in one patient, partial deafness and dizziness have also been reported. Rarely, some patients receiving oral furazolidone experience a disulfiram-like reaction to alcohol. Polyneuritis and hemolytic anemia (in patients with glucose-6-phosphate dehydrogenase deficiency and in neonates) also have been reported rarely.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 861


For more Drug Warnings (Complete) data for FURAZOLIDONE (6 total), please visit the HSDB record page.


4.3 Drug Indication

For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is based upon its interference with DNA replication and protein production; this antimicrobial action minimizes the development of resistant organisms.


5.2 MeSH Pharmacological Classification

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


Antitrichomonal Agents

Agents used to treat trichomonas infections. (See all compounds classified as Antitrichomonal Agents.)


Monoamine Oxidase Inhibitors

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)


Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)


5.3 ATC Code

G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AX - Other antiinfectives and antiseptics

G01AX06 - Furazolidone


5.4 Absorption, Distribution and Excretion

Absorption

Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration


After a single oral dose of 100 mg/kg body weight to rats, only 3% of the dose was recovered in the feces as unmetabolized compound.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V31 145 (1983)


5.5 Metabolism/Metabolites

Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Two major metabolites are produced: 3-amino-2-oxazolidone (AOZ) or beta-hydroxyethylhydrazine (HEH). AOZ is responsible for monoamine oxidase inhibition. Detoxification and elimination of the drug is done primarily by conjugation with glutathione.


In vitro metabolism of furazolidone by milk xanthine oxidase and rat liver homogenate yielded approximately equal amounts (30%) of 2,3-dihydro-3-cyano-methyl-2-hydroxyl-5-nitro-1a,2-di(2-oxo-oxazolidine-3-yl)imi nomethylfuro(2,3b)furan, and 3-(4-cyano-2-oxobutyl-lideneamino)-2-oxazolidone. The latter was also isolated from the urine of rabbits given on oral dose of furazolidone.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V31 146 (1983)


Furazolidone is an antimicrobial compound used in human and veterinary medicine. The aim of this investigation was to determine its genotoxic capacity in vitro and in vivo. We used the human lymphocyte culture system to detect the effect of 2.0, 4.0, 6.0, 8.0, or 10.0 ug/ml, and the mouse bone marrow assay to determine the effect of 8.6, 30.0, or 75.0 mg/kg furazolidone. In both systems we determined the frequency of sister-chromatid exchanges (SCE), the cell proliferation kinetics (CPK), and the mitotic index (MI). The in vitro results showed a significant SCE increase starting from the second dose tested and a CPK and MI decrease starting from the third dose. The in vivo results showed a SCE increase with the two high doses tested, but no significant modification was found in the CPK and MI with the three doses tested in the experiment.

PMID:9169063 Madrigal-Bujaidar E et al; J Toxicol Environ Health 51 (1): 89-96 (1997)


In vitro metabolism of furazolidone (N-(5-nitro-2-furfuryliden)-3-amino-2-oxazolidone) was investigated by using milk xanthine oxidase and rat liver 9000 g supernatant. A new type of reduction product was isolated as 1 of the main metabolites from the incubation mixture and it was tentatively identified as 2,3-dihydro-3-cyanomethyl-2-hydroxyl-5-nitro-1a,2-di(2-oxo-oxazolidin-3-yl)imino methyl-furo(2,3-b)furan. The formation of N-(5-amino-2-furfurylidene)-3-amino-2-oxazolidone as a minor metabolite of nitrofuran in a milk xanthine oxidase system was demonstrated. The aminofuran derivative was easily degraded by milk xanthine oxidase under aerobic, but not anaerobic, conditions. The degradation appears to be due to superoxide anion radicals, hydroxy radicals and/or singlet O2, which are produced in this enzyme system. (Furazolidone, an antibacterial nitrofuran widely used as a veterinary medicine, was mutagenic in Escherichia coli WP2 and Salmonella typhimurium TA100 and tumorigenic in rats).

PMID:6894838 Tatsumi K et al; Arch Biochem Biophys 208 (1): 167-174 (1981)


5.6 Biological Half-Life

10 minutes


5.7 Mechanism of Action

Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.


We are studying the development of unilateral malformations. Several chemicals elicit right sided limb defects both in vivo and in vitro. For example, nitroheterocyclics such as furazolidone (FZ) induce asymmetric defects in rat embryos in vitro. Potential mechanisms include asymmetric drug delivery; intrinsic difference between the cells of the left and right limbs; physiological asymmetry (e.g. in tissue oxygen), secondary to another primary asymmetry (e.g. in limb vasculature). In one series of experiments, we have investigated the role of an asymmetry in drug delivery and/or tissue oxygen. 10.3 days embryonic age rat embryos were explanted and cultured for two hours to allow 'recovery'. Embryos were then exteriorised (removal from yolk sac and amnion, retaining intact circulation) and cultured in the presence of 20 uM FZ with 5% O2 for 24h. The assumption was that exteriorisation would abolish any drug delivery or tissue oxygen asymmetry, by direct embryonic exposure to the medium. As previously described, FZ induced right sided defects (limb, eye and fore-brain) in 42% of intact yolk sac embryos. In contrast, exposure of exteriorised embryos to FZ induced a 34% incidence of abnormalities which were identical, but exclusively left sided. The results do not support a simple hypothesis that asymmetric drug delivery or tissue oxygen levels are responsible for the unilateral defects. We are investigating two potential explanations: a) Exteriorisation specifically reverses limb bud susceptibility, b) A secondary asymmetry e.g. mitochondrial maturity is altered by exteriorisation which then acts to invert the limb response. In a second series of experiments, we have also investigated a possible primary asymmetry in the development of the limb vasculature, using whole mount in situ hybridisation with a probe specific for early endothelial cell precursors (flk-1). The results are being analysed using confocal microscopy to image the limb vascular architecture.

Narburgh LJ, Brown NA; Teratology 50 (5): 24A (1994)


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CHINA ., .,China China","customerAddress":"201A,KIRSHNA NAGARI,OPP SONY MONY,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715970600,"product":"FURAZOLIDONE (NOT FOR MEDICINAL USE)","address":"52, MADHAV APTS.,","city":"MUMBAI, MAHARASHTRA","supplier":"WELFULL GROUP CO ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M S HEALTHCARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"15.7","totalValueFC":"79655.3","currency":"USD","unitRateINR":"1327.9","date":"18-May-2024","totalValueINR":"6639604.5","totalValueInUsd":"79655.3","indian_port":"JNPT","hs_no":"29349990","bill_no":"3541152","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"D TOWER, OCEAN INTERNATIONAL CENTER, NO. 333, YUANJIAN ROAD, GONGSHU DISTRICT HANGZHOU, ZHEJIANG Hangzhou CHINA","customerAddress":"52, MADHAV APTS.,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720809000,"product":"FURAZOLIDONE FEED GRADE (NOT FOR MEDICINAL USE)","address":"AGARWAL B2B CENTRE, 604 KANCHPADA","city":"MUMBAI","supplier":"ZHEJIANG JINLIAN CHEMTECH ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SUN RISE ENTERPRISES","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"15.7","totalValueFC":"64189.9","currency":"USD","unitRateINR":"1341.4","date":"13-Jul-2024","totalValueINR":"5365702","totalValueInUsd":"64189.9","indian_port":"JNPT","hs_no":"29419090","bill_no":"4483688","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"ROOM.1501,ZMI PLAZA NO 445KAIXUAN RD HANGZHOUPR CHINA CN","customerAddress":"AGARWAL B2B CENTRE, 604 KANCHPADA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724783400,"product":"FURAZOLIDONE(NOT FOR MEDICINAL USE)","address":"40,MANGALDAS BLDG NO.1,","city":"MUMBAI ,MAHARASHTRA","supplier":"QINGDAO HAOSAIL SCIENCE ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"TRADE IMPEX INTERNATIONAL","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"16.5","totalValueFC":"16504.2","currency":"USD","unitRateINR":"1384.4","date":"28-Aug-2024","totalValueINR":"1384350","totalValueInUsd":"16504.2","indian_port":"JNPT","hs_no":"29419090","bill_no":"5292428","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"22 FLOOR AMAZON JOINT INNOVATIONCENTER, JIUSHUI EAST ROAD QINGDAOSDNF CN","customerAddress":"40,MANGALDAS BLDG NO.1,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727116200,"product":"FURAZOLIDONE FEED GRADE (ANIMAL FEED SUPPLEMENT\/NOT FOR HUMAN MEDICIAL USE)","address":"Floor 6, Plot no.41,Merchant Chambers,V Thackarsey","city":"MUMBAI","supplier":"QUZHOU WEIRONG PHARMACEUTICAL &","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PHARMA VET","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"15.2","totalValueFC":"46082","currency":"USD","unitRateINR":"1287.2","date":"24-Sep-2024","totalValueINR":"3861730.97","totalValueInUsd":"46082","indian_port":"JNPT","hs_no":"29349990","bill_no":"5780109","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"CHEMICAL CO LTD, NO 249 SHAJIN AVENUE KECHENG QUZHOU, ZHEJIANG, CHINA","customerAddress":"Floor 6, Plot no.41,Merchant Chambers,V Thackarsey"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730831400,"product":"FURAZOLIDONE (NOT FOR MEDICINAL USE)","address":"52, MADHAV APTS.,","city":"MUMBAI, MAHARASHTRA","supplier":"WELFULL GROUP CO ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"M S HEALTHCARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"15.8","totalValueFC":"79619.1","currency":"USD","unitRateINR":"1343.8","date":"06-Nov-2024","totalValueINR":"6718912.1","totalValueInUsd":"79619.1","indian_port":"JNPT","hs_no":"29349990","bill_no":"6517439","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"D TOWER, OCEAN INTERNATIONAL CENTER , NO. 333, YUANJIAN ROAD, GONGSHU D ISTRICT HANGZHOU, ZHEJIANG Hangzhou CHINA","customerAddress":"52, MADHAV APTS.,"}]
09-Jan-2021
16-Nov-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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FDF Dossiers

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01

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Furazolidone

Brand Name :

Dosage Form : Tablet

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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02

Duphat
Not Confirmed
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Furazolidone

Brand Name :

Dosage Form : Capsule

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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03

Duphat
Not Confirmed
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Duphat
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Metronidazole; Furazolidone

Brand Name : Antibic

Dosage Form : Tablet

Dosage Strength : 200MG; 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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04

SHIRE PLC

Ireland
Duphat
Not Confirmed
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SHIRE PLC

Ireland
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Duphat
Not Confirmed

FURAZOLIDONE

Brand Name : FUROXONE

Dosage Form : TABLET;ORAL

Dosage Strength : 100MG

Packaging :

Approval Date : 1982-01-01

Application Number : 11270

Regulatory Info : DISCN

Registration Country : USA

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05

SHIRE PLC

Ireland
Duphat
Not Confirmed
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SHIRE PLC

Ireland
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Duphat
Not Confirmed

FURAZOLIDONE

Brand Name : FUROXONE

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 50MG/15ML

Packaging :

Approval Date : 1982-01-01

Application Number : 11323

Regulatory Info : DISCN

Registration Country : USA

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ABOUT THIS PAGE

Furazolidone Manufacturers

A Furazolidone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Furazolidone, including repackagers and relabelers. The FDA regulates Furazolidone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Furazolidone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Furazolidone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Furazolidone Suppliers

A Furazolidone supplier is an individual or a company that provides Furazolidone active pharmaceutical ingredient (API) or Furazolidone finished formulations upon request. The Furazolidone suppliers may include Furazolidone API manufacturers, exporters, distributors and traders.

click here to find a list of Furazolidone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Furazolidone USDMF

A Furazolidone DMF (Drug Master File) is a document detailing the whole manufacturing process of Furazolidone active pharmaceutical ingredient (API) in detail. Different forms of Furazolidone DMFs exist exist since differing nations have different regulations, such as Furazolidone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Furazolidone DMF submitted to regulatory agencies in the US is known as a USDMF. Furazolidone USDMF includes data on Furazolidone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Furazolidone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Furazolidone suppliers with USDMF on PharmaCompass.

Furazolidone JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Furazolidone Drug Master File in Japan (Furazolidone JDMF) empowers Furazolidone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Furazolidone JDMF during the approval evaluation for pharmaceutical products. At the time of Furazolidone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Furazolidone suppliers with JDMF on PharmaCompass.

Furazolidone NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Furazolidone as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Furazolidone API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Furazolidone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Furazolidone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Furazolidone NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Furazolidone suppliers with NDC on PharmaCompass.

Furazolidone GMP

Furazolidone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Furazolidone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Furazolidone GMP manufacturer or Furazolidone GMP API supplier for your needs.

Furazolidone CoA

A Furazolidone CoA (Certificate of Analysis) is a formal document that attests to Furazolidone's compliance with Furazolidone specifications and serves as a tool for batch-level quality control.

Furazolidone CoA mostly includes findings from lab analyses of a specific batch. For each Furazolidone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Furazolidone may be tested according to a variety of international standards, such as European Pharmacopoeia (Furazolidone EP), Furazolidone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Furazolidone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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