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Chemistry

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Also known as: Thip, 64603-91-4, Gaboxadolum, Gaboxadolum [latin], 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, Mk-0928
Molecular Formula
C6H8N2O2
Molecular Weight
140.14  g/mol
InChI Key
ZXRVKCBLGJOCEE-UHFFFAOYSA-N
FDA UNII
K1M5RVL18S

Gaboxadol
Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives.
1 2D Structure

Gaboxadol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
2.1.2 InChI
InChI=1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9)
2.1.3 InChI Key
ZXRVKCBLGJOCEE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CNCC2=C1C(=O)NO2
2.2 Other Identifiers
2.2.1 UNII
K1M5RVL18S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

2. Lu 2030

3. Lu-2-030

4. Thip

2.3.2 Depositor-Supplied Synonyms

1. Thip

2. 64603-91-4

3. Gaboxadolum

4. Gaboxadolum [latin]

5. 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

6. Mk-0928

7. Lu 02-030

8. 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one

9. 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol

10. Lu-02-030

11. Prestwick-13b03

12. Lu-02030

13. Chebi:34373

14. 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2h)-one

15. K1m5rvl18s

16. Zinc19795995

17. Nsc-759585

18. Ncgc00015982-05

19. Isoxazolo(5,4-c)pyridin-3(2h)-one, 4,5,6,7-tetrahydro-

20. Isoxazolo[5,4-c]pyridin-3(2h)-one, 4,5,6,7-tetrahydro-

21. Gaboxadol [usan:inn]

22. Dsstox_cid_25206

23. Dsstox_rid_80750

24. Dsstox_gsid_45206

25. Gaboxadol [inn]

26. Cas-64603-91-4

27. Gaboxadol (usan/inn)

28. Einecs 264-963-0

29. Unii-k1m5rvl18s

30. 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-one

31. Ei7

32. 4,5,6,7-tetrahydroisoxazole(5,4-c)pyridin-3-ol

33. Spectrum_001484

34. Tocris-0807

35. Gaboxadol [mi]

36. Lopac-t-101

37. Gaboxadol [usan]

38. Prestwick0_000972

39. Prestwick1_000972

40. Prestwick2_000972

41. Prestwick3_000972

42. Spectrum2_001590

43. Spectrum3_000728

44. Spectrum4_000172

45. Spectrum5_001907

46. Biomol-nt_000235

47. Gaboxadol [who-dd]

48. Lopac0_001233

49. Bspbio_001003

50. Bspbio_002256

51. Kbiogr_000683

52. Kbioss_001964

53. Divk1c_000211

54. Spbio_001560

55. Spbio_002914

56. Bpbio1_000420

57. Bpbio1_001105

58. Chembl312443

59. Gtpl4322

60. Dtxsid0045206

61. Bdbm82002

62. Kbio1_000211

63. Kbio2_001964

64. Kbio2_004532

65. Kbio2_007100

66. Kbio3_001476

67. Ninds_000211

68. Bcp07031

69. Nsc_3448

70. Tox21_110271

71. Bdbm50224809

72. Mfcd05664626

73. Ov-101

74. Akos006282519

75. Tox21_110271_1

76. Ccg-205307

77. Db06554

78. Nsc 759585

79. Sb18782

80. Sdccgsbi-0051200.p004

81. Idi1_000211

82. Ncgc00015982-01

83. Ncgc00015982-02

84. Ncgc00015982-03

85. Ncgc00015982-04

86. Ncgc00015982-06

87. Ncgc00015982-07

88. Ncgc00015982-13

89. Ncgc00024801-01

90. Ncgc00024801-02

91. Ncgc00024801-03

92. Ncgc00263653-01

93. Hy-10232

94. Sy253214

95. Sbi-0051200.p003

96. Cas_64603-91-4

97. Ab00053777

98. Cs-0002507

99. Ft-0774669

100. D04282

101. Ab00053777_07

102. 4,5,6,7-tetrahydro-isoxazolo[5,4-c]pyridin-3-ol

103. 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-one

104. 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol

105. 4h,5h,6h,7h-[1,2]oxazolo[5,4-c]pyridin-3-ol

106. Q4130924

107. 2h,3h,4h,5h,6h,7h-[1,2]oxazolo[5,4-c]pyridin-3-one

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 140.14 g/mol
Molecular Formula C6H8N2O2
XLogP3-0.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass140.058577502 g/mol
Monoisotopic Mass140.058577502 g/mol
Topological Polar Surface Area50.4 Ų
Heavy Atom Count10
Formal Charge0
Complexity210
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in sleep disorders and insomnia.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

GABA Agonists

Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). (See all compounds classified as GABA Agonists.)


Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)


Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


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ABOUT THIS PAGE

Gaboxadol Manufacturers

A Gaboxadol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gaboxadol, including repackagers and relabelers. The FDA regulates Gaboxadol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gaboxadol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gaboxadol Suppliers

A Gaboxadol supplier is an individual or a company that provides Gaboxadol active pharmaceutical ingredient (API) or Gaboxadol finished formulations upon request. The Gaboxadol suppliers may include Gaboxadol API manufacturers, exporters, distributors and traders.

Gaboxadol GMP

Gaboxadol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gaboxadol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gaboxadol GMP manufacturer or Gaboxadol GMP API supplier for your needs.

Gaboxadol CoA

A Gaboxadol CoA (Certificate of Analysis) is a formal document that attests to Gaboxadol's compliance with Gaboxadol specifications and serves as a tool for batch-level quality control.

Gaboxadol CoA mostly includes findings from lab analyses of a specific batch. For each Gaboxadol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gaboxadol may be tested according to a variety of international standards, such as European Pharmacopoeia (Gaboxadol EP), Gaboxadol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gaboxadol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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