Find Galeterone manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 851983-85-2, Tok-001, Vn/124-1, Galaterone, Tok 001, Vn/124
Molecular Formula
C26H32N2O
Molecular Weight
388.5  g/mol
InChI Key
PAFKTGFSEFKSQG-PAASFTFBSA-N
FDA UNII
WA33E149SW

Galeterone
Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.
1 2D Structure

Galeterone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
2.1.2 InChI
InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
2.1.3 InChI Key
PAFKTGFSEFKSQG-PAASFTFBSA-N
2.1.4 Canonical SMILES
CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O
2.1.5 Isomeric SMILES
C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O
2.2 Other Identifiers
2.2.1 UNII
WA33E149SW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 17-(1h-benzimidazol-1-yl)androsta-5,16-dien-3beta-ol

2. 3-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene

3. Vn-124-1

2.3.2 Depositor-Supplied Synonyms

1. 851983-85-2

2. Tok-001

3. Vn/124-1

4. Galaterone

5. Tok 001

6. Vn/124

7. Galeterone [usan]

8. Tok-001 (galeterone)

9. Vn 124

10. Vn-124-1

11. Wa33e149sw

12. (3s,8r,9s,10r,13s,14s)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1h-cyclopenta[a]phenanthren-3-ol

13. Galeterone (usan)

14. Vn-124

15. 3-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene

16. (3s,8r,9s,10r,13s,14s)-17-(1h-benzo[d]imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol

17. Galeterone [usan:inn]

18. Unii-wa33e149sw

19. (3beta)-17-(1h-benzimidazol-1-yl)androsta-5,16-dien-3-ol

20. Tok-001(galeterone)

21. Tok-001; Galeterone

22. Galeterone [inn]

23. Galeterone [who-dd]

24. Schembl939234

25. Gtpl8638

26. 17-(1h-benzimidazol-1-yl)androsta-5,16-dien-3beta-ol

27. Chembl2105738

28. Galeterone, >=98% (hplc)

29. Chebi:177536

30. (3?)-17-(1h-benzimidazol-1-yl)androsta-5,16-dien-3-ol

31. 3beta-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene

32. Bcpp000040

33. Dtxsid101025602

34. Amy27882

35. Bcp02827

36. Ex-a1025

37. Zinc6718442

38. Bdbm50435990

39. Mfcd16660907

40. Akos005146524

41. Cs-0334

42. Db12415

43. Ac-26549

44. As-56204

45. Hy-70006

46. D10125

47. J-501178

48. Q5518498

49. Vn/124-1;tok-001;vn 124;tok001;tok 001

50. 3beta-hydroxy-17-(1h-benzimidazol-1-yl)-androsta-5,16-diene

51. 3beta-hydroxy-17-(1h-benzimidazol-1-yl)androsta-5,16-diene

52. Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-

53. Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3.beta.)-

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 388.5 g/mol
Molecular Formula C26H32N2O
XLogP35.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass388.251463648 g/mol
Monoisotopic Mass388.251463648 g/mol
Topological Polar Surface Area38 Ų
Heavy Atom Count29
Formal Charge0
Complexity743
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


ABOUT THIS PAGE

Galeterone Manufacturers

A Galeterone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Galeterone, including repackagers and relabelers. The FDA regulates Galeterone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Galeterone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Galeterone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Galeterone Suppliers

A Galeterone supplier is an individual or a company that provides Galeterone active pharmaceutical ingredient (API) or Galeterone finished formulations upon request. The Galeterone suppliers may include Galeterone API manufacturers, exporters, distributors and traders.

click here to find a list of Galeterone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Galeterone GMP

Galeterone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Galeterone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Galeterone GMP manufacturer or Galeterone GMP API supplier for your needs.

Galeterone CoA

A Galeterone CoA (Certificate of Analysis) is a formal document that attests to Galeterone's compliance with Galeterone specifications and serves as a tool for batch-level quality control.

Galeterone CoA mostly includes findings from lab analyses of a specific batch. For each Galeterone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Galeterone may be tested according to a variety of international standards, such as European Pharmacopoeia (Galeterone EP), Galeterone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Galeterone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty