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Gallium Maltolate

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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2 Drugs in Development

Synopsis

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Chemistry

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Also known as: 108560-70-9, Gallium tris(2-methyl-4-oxo-4h-pyran-3-olate), 17lei49c2g, Gallium maltolate [inci], Gallium;2-methyl-4-oxopyran-3-olate, Db05420

Molecular Formula

C₁₈H₁₅GaO₉

Molecular Weight

445.0 g/mol

InChI Key

ASYYOZSDALANRF-UHFFFAOYSA-K

FDA UNII

17LEI49C2G

Gallium Maltolate is an orally bioavailable form of the element gallium (Ga) composed of a trivalent gallium cation (Ga3+) coordinated to three maltolate ligands, with anti-inflammatory, anti-proliferative, antineoplastic, analgesic, antiresorptive and antibacterial activities. Upon administration of gallium maltolate, Ga3+, which is structurally similar to the ferric ion (Fe3+), competes with and replaces Fe3+ in many vital Fe 3+-mediated biological reactions.. Unlike Fe3+, Ga3+ cannot be reduced, cannot participate in redox reactions and cannot mimic Fe3+ functions. In rapidly proliferating cells, such as cancer cells, high amounts of iron are needed for DNA synthesis. The incorporation of Ga3+ inactivates the Fe3+-dependent enzyme ribonucleotide reductase (RR), an enzyme essential for DNA synthesis, leading to an inhibition of DNA synthesis and induction of cell death in rapidly proliferating cells. Gallium similarly reduces bacterial cell growth. In addition, Ga3+ is able to suppress inflammation through the down-regulation of pro-inflammatory cells and the inhibition of pro-inflammatory cytokine secretion. Gallium also exerts analgesic effects due to the inhibition of Fe3+-dependent enzymes involved in inflammation and may interfere with the activity of certain metalloproteinases and neuropeptides that are implicated in pain. Also, gallium is able to inhibit bone resorption by osteoclasts, may inhibit metastasis to bone and may prevent the destruction of bone by tumors.

1 2D Structure

Gallium Maltolate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

gallium;2-methyl-4-oxopyran-3-olate

2.1.2 InChI

InChI=1S/3C6H6O3.Ga/c3*1-4-6(8)5(7)2-3-9-4;/h3*2-3,8H,1H3;/q;;;+3/p-3

2.1.3 InChI Key

ASYYOZSDALANRF-UHFFFAOYSA-K

2.1.4 Canonical SMILES

CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Ga+3]

2.2 Other Identifiers

2.2.1 UNII

17LEI49C2G

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4h-pyran-4-one, 3-hydroxy-2-methyl-, Gallium Salt (3:1)

2. Tris(3-hydroxy-2-methyl-4h-pyran-4-onato)gallium(iii)

3. Tris(maltolato)gallium(iii)

2.3.2 Depositor-Supplied Synonyms

1. 108560-70-9

2. Gallium Tris(2-methyl-4-oxo-4h-pyran-3-olate)

3. 17lei49c2g

4. Gallium Maltolate [inci]

5. Gallium;2-methyl-4-oxopyran-3-olate

6. Db05420

7. B2699-054157

8. 3-bis[(2-methyl-4-oxopyran-3-yl)oxy]gallanyloxy-2-methylpyran-4-one

9. Gallium, Tris(3-(hydroxy-.kappa.o)-2-methyl-4h-pyran-4-onato-.kappa.o4)-, (oc-6-21)-

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₅GaO₉
Molecular Weight	445.0 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	0
Exact Mass	g/mol
Monoisotopic Mass	g/mol
Topological Polar Surface Area	148
Heavy Atom Count	28
Formal Charge	0
Complexity	200
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in bladder cancer, lymphoma (unspecified), multiple myeloma, paget's disease, and prostate cancer.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

Gallium maltolate is a novel orally active formulation of gallium, a semi-metallic element that is a potent inhibitor of ribonucleotide reductase, an enzyme that promotes tumor growth.Gallium is also known to concentrate in malignant tumors and sites of infection, and appears to favorably impact calcium deposition, making bones more resistant to degradation caused by cancer metastasis. Titan's novel product, gallium maltolate, may significantly expand the therapeutic potential of gallium by providing the advantages of enhanced bioavailablity, a potentially improved therapeutic profile and ease of administration.

Drugs in Development

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ABOUT THIS PAGE

Gallium Maltolate Manufacturers

A Gallium Maltolate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gallium Maltolate, including repackagers and relabelers. The FDA regulates Gallium Maltolate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gallium Maltolate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gallium Maltolate Suppliers

A Gallium Maltolate supplier is an individual or a company that provides Gallium Maltolate active pharmaceutical ingredient (API) or Gallium Maltolate finished formulations upon request. The Gallium Maltolate suppliers may include Gallium Maltolate API manufacturers, exporters, distributors and traders.

Gallium Maltolate GMP

Gallium Maltolate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gallium Maltolate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gallium Maltolate GMP manufacturer or Gallium Maltolate GMP API supplier for your needs.

Gallium Maltolate CoA

A Gallium Maltolate CoA (Certificate of Analysis) is a formal document that attests to Gallium Maltolate's compliance with Gallium Maltolate specifications and serves as a tool for batch-level quality control.

Gallium Maltolate CoA mostly includes findings from lab analyses of a specific batch. For each Gallium Maltolate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gallium Maltolate may be tested according to a variety of international standards, such as European Pharmacopoeia (Gallium Maltolate EP), Gallium Maltolate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gallium Maltolate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.