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Chemistry

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Also known as: 700874-72-2, Ly2157299, Ly 2157299, Ly-2157299, 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide, Unii-3okh1w5lze
Molecular Formula
C22H19N5O
Molecular Weight
369.4  g/mol
InChI Key
IVRXNBXKWIJUQB-UHFFFAOYSA-N
FDA UNII
3OKH1W5LZE

Galunisertib
Galunisertib is an orally available, small molecule antagonist of the tyrosine kinase transforming growth factor-beta (TGF-b) receptor type 1 (TGFBR1), with potential antineoplastic activity. Upon administration, galunisertib specifically targets and binds to the kinase domain of TGFBR1, thereby preventing the activation of TGF-b-mediated signaling pathways. This may inhibit the proliferation of TGF-b-overexpressing tumor cells. Dysregulation of the TGF-b signaling pathway is seen in a number of cancers and is associated with increased cancer cell proliferation, migration, invasion and tumor progression.
1 2D Structure

Galunisertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
2.1.2 InChI
InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
2.1.3 InChI Key
IVRXNBXKWIJUQB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
3OKH1W5LZE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo(1,2-b)pyrazol-3-yl)quinoline-6-carboxylic Acid Amide

2. Ly 2157299

3. Ly-2157299

4. Ly2157299

2.3.2 Depositor-Supplied Synonyms

1. 700874-72-2

2. Ly2157299

3. Ly 2157299

4. Ly-2157299

5. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

6. Unii-3okh1w5lze

7. Ly2157299(galunisertib)

8. Galunisertib (ly2157299)

9. Galunisertib [usan]

10. 3okh1w5lze

11. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo-[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

12. 4-[2-(6-methylpyridin-2-yl)-4h,5h,6h-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide

13. 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide

14. Galunisertib (usan)

15. 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4h-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide

16. 6-quinolinecarboxamide, 4-(5,6-dihydro-2-(6-methyl-2-pyridinyl)-4h-pyrrolo(1,2-b)pyrazol-3-yl)-

17. Galunisertib [usan:inn]

18. Galunisertibum

19. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo(1,2-b)pyrazol-3-yl)quinoline-6-carboxamide

20. Galunisertib [inn]

21. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo(1,2-b)pyrazol-3-yl)quinoline-6-carboxylic Acid Amide

22. Galunisertib [who-dd]

23. Gtpl7797

24. Chembl2364611

25. Schembl12922153

26. Amy9045

27. Dtxsid00220362

28. Ex-a009

29. Chebi:137064

30. Hms3655d14

31. Bcp02173

32. Zinc3959536

33. Bdbm50015640

34. Mfcd12923319

35. Nsc761216

36. Nsc800103

37. S2230

38. Akos022175280

39. Ccg-264950

40. Cs-0474

41. Db11911

42. Ex-8675

43. Nsc-761216

44. Nsc-800103

45. Sb16483

46. Lyl-2157299

47. Ncgc00384167-07

48. Ac-31327

49. As-42940

50. Hy-13226

51. Inhibitor 15d [pmid: 18314943]

52. Ft-0741808

53. Sw219460-1

54. D10437

55. A836766

56. J-514250

57. Q27077768

58. 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide, Aldrichcpr

59. 4-[2-(6-methyl-2-pyridinyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide

60. 4-[2-(6-methyl-2-pyridinyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamideorly215

61. 4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline-6-carboxylic Acid Amide

62. 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[2,1-e]pyrazol-3-yl]quinoline-6-carboxamide

63. 6-quinolinecarboxamide, 4-(5,6-dihydro-2-(6-methyl-2-pyridinyl)-4h-pyrrolo(1,2-b)pyrazol-3-yl)-)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 369.4 g/mol
Molecular Formula C22H19N5O
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass369.15896025 g/mol
Monoisotopic Mass369.15896025 g/mol
Topological Polar Surface Area86.7 Ų
Heavy Atom Count28
Formal Charge0
Complexity585
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 700874-72-2 / Galunisertib API manufacturers, exporters & distributors?

Galunisertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Galunisertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Galunisertib manufacturer or Galunisertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Galunisertib manufacturer or Galunisertib supplier.

PharmaCompass also assists you with knowing the Galunisertib API Price utilized in the formulation of products. Galunisertib API Price is not always fixed or binding as the Galunisertib Price is obtained through a variety of data sources. The Galunisertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Galunisertib

Synonyms

700874-72-2, Ly2157299, Ly 2157299, Ly-2157299, 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide, Unii-3okh1w5lze

Cas Number

700874-72-2

Unique Ingredient Identifier (UNII)

3OKH1W5LZE

About Galunisertib

Galunisertib is an orally available, small molecule antagonist of the tyrosine kinase transforming growth factor-beta (TGF-b) receptor type 1 (TGFBR1), with potential antineoplastic activity. Upon administration, galunisertib specifically targets and binds to the kinase domain of TGFBR1, thereby preventing the activation of TGF-b-mediated signaling pathways. This may inhibit the proliferation of TGF-b-overexpressing tumor cells. Dysregulation of the TGF-b signaling pathway is seen in a number of cancers and is associated with increased cancer cell proliferation, migration, invasion and tumor progression.

Galunisertib Manufacturers

A Galunisertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Galunisertib, including repackagers and relabelers. The FDA regulates Galunisertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Galunisertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Galunisertib Suppliers

A Galunisertib supplier is an individual or a company that provides Galunisertib active pharmaceutical ingredient (API) or Galunisertib finished formulations upon request. The Galunisertib suppliers may include Galunisertib API manufacturers, exporters, distributors and traders.

Galunisertib GMP

Galunisertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Galunisertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Galunisertib GMP manufacturer or Galunisertib GMP API supplier for your needs.

Galunisertib CoA

A Galunisertib CoA (Certificate of Analysis) is a formal document that attests to Galunisertib's compliance with Galunisertib specifications and serves as a tool for batch-level quality control.

Galunisertib CoA mostly includes findings from lab analyses of a specific batch. For each Galunisertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Galunisertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Galunisertib EP), Galunisertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Galunisertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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