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1. 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one
2. Ccd 1042
3. Ccd-1042
4. Ztalmy
1. 38398-32-2
2. Ccd 1042
3. Ztalmy
4. Ccd-1042
5. 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one
6. 98wi44ohiq
7. 1-((3r,5s,8r,9s,10s,13s,14s,17s)-3-hydroxy-3,10,13-trimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethanone
8. 1-[(3r,5s,8r,9s,10s,13s,14s,17s)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
9. Pregnan-20-one, 3-hydroxy-3-methyl-, (3a,5a)-
10. Ncgc00165802-02
11. Dsstox_cid_26503
12. Dsstox_rid_81672
13. Dsstox_gsid_46503
14. 1-((3r,5s,8r,9s,10s,13s,14s,17s)-3-hydroxy-3,10,13-trimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethan-1-one
15. Cas-38398-32-2
16. Ganaxolone [usan]
17. Ganaxolone [usan:inn]
18. Unii-98wi44ohiq
19. Ganaxolone, Solid
20. Ganaxolone [mi]
21. Ganaxolone [inn]
22. Ganaxolone (usan/inn)
23. Ganaxolone [who-dd]
24. Schembl144522
25. (3alpha,5alpha)-3-hydroxy-3-methylpregnan-20-one
26. Chembl1568698
27. Dtxsid6046503
28. Gtpl11942
29. Ccd1042
30. Chebi:177658
31. Dea No. 2401
32. Hms3261k19
33. Amy38916
34. Zinc3824281
35. Tox21_112264
36. Tox21_500379
37. Bdbm50369240
38. Mfcd09971088
39. Akos027327586
40. Tox21_112264_1
41. Ccg-221683
42. Db05087
43. Lp00379
44. Sdccgsbi-0633706.p001
45. Ncgc00165802-03
46. Ncgc00261064-01
47. Ncgc00263545-01
48. As-35253
49. B7092
50. (3?,5?)-3-hydroxy-3-methyl-pregnan-20-one
51. 3alpha-hydroxy-3-methyl-5alpha-pregnan-20-one
52. D04300
53. A901692
54. (3alpha,5alpha)-3-hydroxy-3-methyl-pregnan-20-one
55. Q3758034
56. 3.alpha.-hydroxy-3-methyl-5.alpha.-pregnan-20-one
57. Pregnan-20-one, 3-hydroxy-3-methyl-, (3alpha,5alpha)-
58. Pregnan-20-one, 3-hydroxy-3-methyl-, (3.alpha.,5.alpha.)-
59. 1-[(3r,5s,8r,9s,10s,13s,14s,17s)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone.
Molecular Weight | 332.5 g/mol |
---|---|
Molecular Formula | C22H36O2 |
XLogP3 | 5 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 1 |
Exact Mass | 332.271530387 g/mol |
Monoisotopic Mass | 332.271530387 g/mol |
Topological Polar Surface Area | 37.3 Ų |
Heavy Atom Count | 24 |
Formal Charge | 0 |
Complexity | 542 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 8 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in pediatric indications and seizure disorders.
Treatment of cyclin-dependent kinase-like 5 deficiency disorder
Ganaxolone is a powerful positive allosteric modulator of GABAA receptors with potency and efficacy comparable to its endogenous analog 3a,5a-P (Carter et al., 1997). As with 3a,5a-P, Ganaxolone potentiation of the GABAA receptor occurs at a site distinct from the benzodiazepine site. Ganaxolone has protective activity in diverse rodent seizure models, including clonic seizures induced by pentylenetetrazol (PTZ) and bicuculline (BIC), limbic seizures in the 6 Hz model, and amygdala kindled seizures (Carter et al., 1997; Rogawski and Reddy, 2004; Kaminski et al., 2004).
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
Neurosteroids
Endogenous compounds or drugs that affect neuronal excitability through modulation of specific ionotropic receptors (e.g., GABA-A RECEPTORS). Endogenous neurosteroids are steroid hormones de novo synthesized by neurons and glial cells from steroid metabolite precursors (e.g., PREGNENOLONE). (See all compounds classified as Neurosteroids.)
N - Nervous system
N03 - Antiepileptics
N03A - Antiepileptics
N03AX - Other antiepileptics
N03AX27 - Ganaxolone
1.3-1.9 hours
Ganaxolone belongs to a novel class of neuroactive steroids called epalons, which specifically modulate the -aminobutyric acid type A (GABAA) receptor in the central nervous system (CNS). Chemically related to progesterone but devoid of any hormonal activity, the epalons have potent antiepileptic, anxiolytic, sedative, and hypnotic activities in animals.