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Chemistry

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Also known as: 194804-75-6, Ganefloxacin, T-3811, T 3811, Bms284756, (r)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Molecular Formula
C23H20F2N2O4
Molecular Weight
426.4  g/mol
InChI Key
NJDRXTDGYFKORP-LLVKDONJSA-N
FDA UNII
V72H9867WB

Garenoxacin
Garenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative bacterial infections.
1 2D Structure

Garenoxacin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid
2.1.2 InChI
InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
2.1.3 InChI Key
NJDRXTDGYFKORP-LLVKDONJSA-N
2.1.4 Canonical SMILES
CC1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
2.1.5 Isomeric SMILES
C[C@@H]1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
2.2 Other Identifiers
2.2.1 UNII
V72H9867WB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bms 284756

2. Bms-284756

3. Bms284756

2.3.2 Depositor-Supplied Synonyms

1. 194804-75-6

2. Ganefloxacin

3. T-3811

4. T 3811

5. Bms284756

6. (r)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

7. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methyl-2,3-dihydro-1h-isoindol-5-yl]-4-oxoquinoline-3-carboxylic Acid

8. V72h9867wb

9. Bms-284756

10. Garenfloxacin

11. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methyl-2,3-dihydro-1h-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

12. 194804-75-6 Pound Not223652-90-2

13. Ncgc00181770-01

14. Garenoxacin [inn:ban]

15. Bms 284756 (*mesylate Salt*)

16. Garenoxacine

17. Garenoxacino

18. Garenoxacinum

19. Unii-v72h9867wb

20. T-3811mea

21. Bms-284756 (*mesylate Salt*)

22. Garenoxacin [mi]

23. Garenoxacin [inn]

24. Garenoxacin [mart.]

25. Garenoxacin [who-dd]

26. Chembl215303

27. Schembl2103727

28. Amy8881

29. Dtxsid30173135

30. Chebi:131716

31. Bcpp000224

32. Bcp01415

33. Ex-a3040

34. Zinc3585048

35. Bdbm50481219

36. S5908

37. Akos015920281

38. Bcp9000709

39. Cs-4989

40. Db06160

41. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

42. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methylisoindolin-5-yl]-4-oxo-quinoline-3-carboxylic Acid

43. 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-2,3-dihydro-1-methyl-1h-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

44. Hy-17460

45. A16856

46. 804g756

47. J-012614

48. J-521409

49. Q3758306

50. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2, 3-dihydro-1h-5-isoindolyl)-4-oxo-1, 4-dihydro-3-quinolinecarboxylic Acid

51. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinoline-carboxylic Acid

52. (r)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 426.4 g/mol
Molecular Formula C23H20F2N2O4
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass426.13911345 g/mol
Monoisotopic Mass426.13911345 g/mol
Topological Polar Surface Area78.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity771
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in bacterial infection.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)


Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01M - Quinolone antibacterials

J01MA - Fluoroquinolones

J01MA19 - Garenoxacin


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26-Aug-2021
26-Aug-2021
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ABOUT THIS PAGE

Garenoxacin Manufacturers

A Garenoxacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Garenoxacin, including repackagers and relabelers. The FDA regulates Garenoxacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Garenoxacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Garenoxacin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Garenoxacin Suppliers

A Garenoxacin supplier is an individual or a company that provides Garenoxacin active pharmaceutical ingredient (API) or Garenoxacin finished formulations upon request. The Garenoxacin suppliers may include Garenoxacin API manufacturers, exporters, distributors and traders.

click here to find a list of Garenoxacin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Garenoxacin USDMF

A Garenoxacin DMF (Drug Master File) is a document detailing the whole manufacturing process of Garenoxacin active pharmaceutical ingredient (API) in detail. Different forms of Garenoxacin DMFs exist exist since differing nations have different regulations, such as Garenoxacin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Garenoxacin DMF submitted to regulatory agencies in the US is known as a USDMF. Garenoxacin USDMF includes data on Garenoxacin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Garenoxacin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Garenoxacin suppliers with USDMF on PharmaCompass.

Garenoxacin GMP

Garenoxacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Garenoxacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Garenoxacin GMP manufacturer or Garenoxacin GMP API supplier for your needs.

Garenoxacin CoA

A Garenoxacin CoA (Certificate of Analysis) is a formal document that attests to Garenoxacin's compliance with Garenoxacin specifications and serves as a tool for batch-level quality control.

Garenoxacin CoA mostly includes findings from lab analyses of a specific batch. For each Garenoxacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Garenoxacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Garenoxacin EP), Garenoxacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Garenoxacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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