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Chemistry

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Also known as: 1197160-78-3, Pki-587, Pf-05212384, Pki 587, 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea, Pki587
Molecular Formula
C32H41N9O4
Molecular Weight
615.7  g/mol
InChI Key
DWZAEMINVBZMHQ-UHFFFAOYSA-N
FDA UNII
96265TNH2R

Gedatolisib
Gedatolisib is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, gedatolisib inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.
1 2D Structure

Gedatolisib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
2.1.2 InChI
InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)
2.1.3 InChI Key
DWZAEMINVBZMHQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6
2.2 Other Identifiers
2.2.1 UNII
96265TNH2R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea

2. Pf-05212384

3. Pki 587

4. Pki-587

5. Pki587

2.3.2 Depositor-Supplied Synonyms

1. 1197160-78-3

2. Pki-587

3. Pf-05212384

4. Pki 587

5. 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea

6. Pki587

7. Pf-05212384 (pki-587)

8. Pf 05212384

9. Chembl592445

10. 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea

11. 96265tnh2r

12. N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-n'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea

13. Gedatolisib (pf-05212384, Pki-587)

14. Pki-587; Pf-05212384

15. Urea, N-(4-((4-(dimethylamino)-1-piperidinyl)carbonyl)phenyl)-n'-(4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl)-

16. 1-(4-((4-(dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea

17. Gedatolisib [usan:inn]

18. Unii-96265tnh2r

19. 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea

20. Urea, N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-n'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]-

21. Pk 587

22. Pk 1587

23. Gedatolisib(pki-587)

24. Gedatolisib [inn]

25. Gedatolisib (usan/inn)

26. Gedatolisib [usan]

27. Gedatolisib (pki-587)

28. Schembl32393

29. Gedatolisib [who-dd]

30. Gtpl7940

31. Dtxsid40152557

32. Ex-a028

33. Hms3748m11

34. Bcp01986

35. Bdbm50308135

36. Mfcd16875679

37. Nsc758256

38. Nsc801014

39. S2628

40. Zinc49757175

41. Akos005766013

42. Ccg-264662

43. Cs-0449

44. Db11896

45. Fe-0013

46. Nsc-758256

47. Nsc-801014

48. Sb16571

49. Ncgc00370777-01

50. Ncgc00370777-04

51. Ac-31519

52. Hy-10681

53. Ft-0700110

54. Pki-587,pf-05212384

55. A25474

56. D10635

57. J-004182

58. J-523339

59. Q27077788

60. Pki-587

61. 1197160-78-3

62. Pki587

63. Pki 587

64. N-(4-((4-(dimethylamino)-1-piperidinyl)carbonyl)phenyl)-n'-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea

65. N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-n'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea

66. N-{4-[4,6-bis(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}-n'-{4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl}urea

67. Vl1

2.4 Create Date
2009-12-22
3 Chemical and Physical Properties
Molecular Weight 615.7 g/mol
Molecular Formula C32H41N9O4
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass615.32815082 g/mol
Monoisotopic Mass615.32815082 g/mol
Topological Polar Surface Area128 Ų
Heavy Atom Count45
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Looking for 1197160-78-3 / Gedatolisib API manufacturers, exporters & distributors?

Gedatolisib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Gedatolisib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Gedatolisib manufacturer or Gedatolisib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Gedatolisib manufacturer or Gedatolisib supplier.

PharmaCompass also assists you with knowing the Gedatolisib API Price utilized in the formulation of products. Gedatolisib API Price is not always fixed or binding as the Gedatolisib Price is obtained through a variety of data sources. The Gedatolisib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Gedatolisib

Synonyms

1197160-78-3, Pki-587, Pf-05212384, Pki 587, 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea, Pki587

Cas Number

1197160-78-3

Unique Ingredient Identifier (UNII)

96265TNH2R

About Gedatolisib

Gedatolisib is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, gedatolisib inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Gedatolisib Manufacturers

A Gedatolisib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gedatolisib, including repackagers and relabelers. The FDA regulates Gedatolisib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gedatolisib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gedatolisib Suppliers

A Gedatolisib supplier is an individual or a company that provides Gedatolisib active pharmaceutical ingredient (API) or Gedatolisib finished formulations upon request. The Gedatolisib suppliers may include Gedatolisib API manufacturers, exporters, distributors and traders.

Gedatolisib GMP

Gedatolisib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gedatolisib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gedatolisib GMP manufacturer or Gedatolisib GMP API supplier for your needs.

Gedatolisib CoA

A Gedatolisib CoA (Certificate of Analysis) is a formal document that attests to Gedatolisib's compliance with Gedatolisib specifications and serves as a tool for batch-level quality control.

Gedatolisib CoA mostly includes findings from lab analyses of a specific batch. For each Gedatolisib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gedatolisib may be tested according to a variety of international standards, such as European Pharmacopoeia (Gedatolisib EP), Gedatolisib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gedatolisib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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