DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 5 Listed Suppliers

5 API Suppliers
5 Listed Suppliers

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Europe

1 FDF Dossiers
1 Europe

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 14 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
14 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Finished Drug Prices

globalSalesInformation
1 Finished Drug Prices

MARKET PLACE

2 APIs

marketPlace
2 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1015787-98-0, Af-219, Mk-7264, Gefapixant [usan], Ro4926219, Rg-1646

Molecular Formula

C₁₄H₁₉N₅O₄S

Molecular Weight

353.40 g/mol

InChI Key

HLWURFKMDLAKOD-UHFFFAOYSA-N

FDA UNII

6K6L7E3F1L

Gefapixant is under investigation in clinical trial NCT02397460 (Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity).

1 2D Structure

Gefapixant Citrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide

2.1.2 InChI

InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)

2.1.3 InChI Key

HLWURFKMDLAKOD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC

2.2 Other Identifiers

2.2.1 UNII

6K6L7E3F1L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-((2,4-diamino-5-pyrimidinyl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

2. Af-219

3. Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-

4. Mk-7264

2.3.2 Depositor-Supplied Synonyms

1. 1015787-98-0

2. Af-219

3. Mk-7264

4. Gefapixant [usan]

5. Ro4926219

6. Rg-1646

7. Ro-4926219

8. Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-

9. 6k6l7e3f1l

10. R-1646

11. Af219

12. Rg1646

13. Mk-7264;af-219

14. R1646

15. 5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide

16. C14h19n5o4s

17. 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

18. 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide

19. 5-[(2,4-diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide

20. 5-((2,4-diaminopyrimidin-5-yl)oxy)-2-methoxy-4-(propan-2-yl)benzenesulfonamide

21. 5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide

22. Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-

23. 5-((2,4-diamino-5-pyrimidinyl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

24. Gefapixant [inn]

25. Gefapixant (usan/inn)

26. Gefapixant [who-dd]

27. Unii-6k6l7e3f1l

28. Gtpl9540

29. Schembl1493905

30. Chembl3716057

31. Dtxsid401337212

32. Amy27911

33. Bcp26079

34. Ex-a2788

35. Gefapixant(af-219,mk-7264)

36. Bdbm50533006

37. Mfcd24539325

38. S6664

39. Akos037515637

40. Zinc116342482

41. Db15097

42. Af-219; Mk-7264

43. Ac-35643

44. As-78086

45. Bm170818

46. Sy282739

47. Hy-101588

48. Cs-0021727

49. Ro 4926219

50. J3.556.891c

51. D11349

52. A934898

53. 2-methoxy-4-isopropyl-5-(2,4-diamino-5-pyrimidinyloxy)benzenesulfonamide

54. 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide

55. Af9

2.4 Create Date

2008-04-21

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₉N₅O₄S
Molecular Weight	353.40 g/mol
XLogP3	0.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	353.11577528 g/mol
Monoisotopic Mass	353.11577528 g/mol
Topological Polar Surface Area	165 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	512
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1