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Chemistry

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Also known as: Gemcitabine hcl, 122111-03-9, Gemzar, Ly188011 hydrochloride, Gemcitabine (hydrochloride), 2'-deoxy-2',2'-difluorocytidine monohydrochloride
Molecular Formula
C9H12ClF2N3O4
Molecular Weight
299.66  g/mol
InChI Key
OKKDEIYWILRZIA-OSZBKLCCSA-N
FDA UNII
U347PV74IL

Gemcitabine
A deoxycytidine antimetabolite used as an antineoplastic agent.
1 2D Structure

Gemcitabine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
2.1.2 InChI
InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
2.1.3 InChI Key
OKKDEIYWILRZIA-OSZBKLCCSA-N
2.1.4 Canonical SMILES
C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl
2.1.5 Isomeric SMILES
C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
2.2 Other Identifiers
2.2.1 UNII
U347PV74IL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 188011, Ly

2. 2' Deoxy 2' Difluorocytidine

3. 2' Deoxy 2',2'' Difluorocytidine 5' O Monophosphate

4. 2',2'-dfdc

5. 2',2'-difluoro-2'-deoxycytidine

6. 2',2'-difluorodeoxycytidine

7. 2'-deoxy-2',2''-difluorocytidine-5'-o-monophosphate

8. 2'-deoxy-2'-difluorocytidine

9. Dfdcyd

10. Gemcitabine

11. Gemcitabine, (alpha-d-threo-pentofuranosyl)-isomer

12. Gemcitabine, (beta-d-threo-pentafuranosyl)-isomer

13. Gemcitabine, (d-threo-pentafuranosyl)-isomer

14. Gemicitabine

15. Gemzar

16. Hydrochloride, Gemcitabine

17. Ly 188011

18. Ly-188011

2.3.2 Depositor-Supplied Synonyms

1. Gemcitabine Hcl

2. 122111-03-9

3. Gemzar

4. Ly188011 Hydrochloride

5. Gemcitabine (hydrochloride)

6. 2'-deoxy-2',2'-difluorocytidine Monohydrochloride

7. Cytidine, 2'-deoxy-2',2'-difluoro-, Monohydrochloride

8. Dfdc

9. 4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one Hydrochloride

10. Gemcitabine (as Hydrochloride)

11. U347pv74il

12. Chebi:31647

13. 2',2'-difluoro-2'-deoxycytidine Hydrochloride

14. Ly-188011 Hydrochloride

15. Ly-188011

16. 122111-03-9 (hcl)

17. Dsstox_cid_27827

18. Dsstox_rid_82590

19. Dsstox_gsid_47849

20. 2'-deoxy-2',2'-difluorocytidine Hydrochloride

21. 4-amino-1-[(2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride

22. Dizirconium Silicide

23. Cas-122111-03-9

24. Gemcitabine Hydrochloride [usan]

25. Gemcitabine Hcl (gemzar)

26. Ly 188011

27. Unii-u347pv74il

28. Mfcd01735988

29. Ncgc00168784-01

30. Gemzar (tn)

31. Infugem

32. Gemcitabine Hydrochloride [usan:usp]

33. Inno-d07001

34. Schembl4366

35. Chembl1637

36. Ly 188011 Hydrochloride

37. Mls003915643

38. Gemcitabine Hydrochloride,(s)

39. Dtxsid3047849

40. Ex-a837

41. 2'-deoxy-2',2'-difluorocytidine Monohydrochloride (beta-isomer)

42. Act06731

43. Hy-b0003

44. Ly-188011 . Hcl

45. Tox21_112644

46. Bdbm50247964

47. Gemcitabine Hydrochloride (jan/usp)

48. S1149

49. Gemcitabine Hydrochloride [mi]

50. Akos015999730

51. Tox21_112644_1

52. Ccg-267459

53. Cs-0755

54. Gemcitabine Hcl (gemzar,ly188011)

55. Gemcitabine Hydrochloride [jan]

56. 2'-deoxy-2',2'-difluorocytidine Hcl

57. Gemcitabine Hydrochloride [mart.]

58. Gemcitabine Hydrochloride [vandf]

59. Ncgc00168784-03

60. As-13656

61. Bg164501

62. Gemcitabine Hydrochloride [usp-rs]

63. Gemcitabine Hydrochloride [who-dd]

64. Smr000469146

65. Gemcitabine Hydrochloride, >=98% (hplc)

66. Gemcitabine Hydrochloride,gemzar, Ly-188011

67. D01155

68. Gemcitabine Hydrochloride [ep Monograph]

69. Gemcitabine Hydrochloride [orange Book]

70. 2'-deoxy-2',2'-difluorocytidine, Hydrochloride

71. Gemcitabine Hydrochloride [usp Monograph]

72. 111g039

73. W-60402

74. (+)-2'-deoxy-2',2'-difluorocytidine Hydrochloride

75. J-700175

76. Q27114559

77. 2'-deoxy-2',2'-difluorocytidine Monohydrochloride (.beta.-isomer)

78. Gemcitabine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

79. Gemcitabine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

80. (2'r,4'r,5'r)-4-amino-1-(3,3-difluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1h-pyridin-2-one Hydrochloride

81. 4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidin-2-one Hydrochloride

82. 4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-onehydrochloride

2.3.3 Other Synonyms

1. Gemcitabine Free Base

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 299.66 g/mol
Molecular Formula C9H12ClF2N3O4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass299.0484399 g/mol
Monoisotopic Mass299.0484399 g/mol
Topological Polar Surface Area108 Ų
Heavy Atom Count19
Formal Charge0
Complexity426
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameGemcitabine hydrochloride
Drug LabelGemzar (gemcitabine for injection, USP) is a nucleoside metabolic inhibitor that exhibits antitumor activity. Gemcitabine HCl is 2-deoxy-2,2-difluorocytidine monohydrochloride (-isomer). The structural formula is as follows: The empirical...
Active IngredientGemcitabine hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 200mg base/vial; 1gm/26.3ml (38mg/ml); 2gm/52.6ml (38mg/ml); 200mg/5.26ml (38mg/ml); eq 1gm base/vial
Market StatusPrescription
CompanyHospira; Jiangsu Hansoh Pharm; Fresenius Kabi Oncol; Accord Hlthcare; Cipla; Sun Pharma Global; Actavis Elizabeth; Emcure Pharms; Teva Pharms; Fresenius Kabi Usa; Onco Therapies; Hameln Rds Gmbh; Luitpold; Sagent Pharms; Dr Reddys Labs

2 of 4  
Drug NameGemzar
PubMed HealthGemcitabine (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelGemzar (gemcitabine for injection, USP) is a nucleoside metabolic inhibitor that exhibits antitumor activity. Gemcitabine HCl is 2-deoxy-2,2-difluorocytidine monohydrochloride (-isomer). The structural formula is as follows: The empirical...
Active IngredientGemcitabine hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 200mg base/vial; eq 1gm base/vial
Market StatusPrescription
CompanyLilly

3 of 4  
Drug NameGemcitabine hydrochloride
Drug LabelGemzar (gemcitabine for injection, USP) is a nucleoside metabolic inhibitor that exhibits antitumor activity. Gemcitabine HCl is 2-deoxy-2,2-difluorocytidine monohydrochloride (-isomer). The structural formula is as follows: The empirical...
Active IngredientGemcitabine hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 2gm base/vial; eq 200mg base/vial; 1gm/26.3ml (38mg/ml); 2gm/52.6ml (38mg/ml); 200mg/5.26ml (38mg/ml); eq 1gm base/vial
Market StatusPrescription
CompanyHospira; Jiangsu Hansoh Pharm; Fresenius Kabi Oncol; Accord Hlthcare; Cipla; Sun Pharma Global; Actavis Elizabeth; Emcure Pharms; Teva Pharms; Fresenius Kabi Usa; Onco Therapies; Hameln Rds Gmbh; Luitpold; Sagent Pharms; Dr Reddys Labs

4 of 4  
Drug NameGemzar
PubMed HealthGemcitabine (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelGemzar (gemcitabine for injection, USP) is a nucleoside metabolic inhibitor that exhibits antitumor activity. Gemcitabine HCl is 2-deoxy-2,2-difluorocytidine monohydrochloride (-isomer). The structural formula is as follows: The empirical...
Active IngredientGemcitabine hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 200mg base/vial; eq 1gm base/vial
Market StatusPrescription
CompanyLilly

4.2 Drug Indication

Treatment of urothelial carcinoma


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Nucleoside Metabolic Inhibitor [EPC]; Nucleic Acid Synthesis Inhibitors [MoA]

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LGM Pharma

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Zhejiang Hisun Pharmaceutical

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DMF Review : Complete

Rev. Date : 2016-06-27

Pay. Date : 2016-06-06

DMF Number : 18857

Submission : 2005-10-11

Status : Active

Type : II

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Hetero Labs Ltd

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Laurus Labs Ltd

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Olon Spa

Italy

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LGM Pharma

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Gemcitabine

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LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
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HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
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Farmhispania

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Gemcitabine

About the Company : Farmhispania Group comprises two companies in Spain: Farmhispania in Barcelona and Rolabo in Zaragoza. Since its inception, the group has consistently invested in advanced equipmen...

Farmhispania Group comprises two companies in Spain: Farmhispania in Barcelona and Rolabo in Zaragoza. Since its inception, the group has consistently invested in advanced equipment, new technologies, and enhanced capabilities. Significant investments include the implementation of hydrogenation technologies in 2007, HPAPI handling capabilities in 2010, highly potent fermentation capabilities in 2014, and the expansion of large-scale preparative chromatography in 2015. Additionally, Farmhispania Group actively collaborates on numerous projects with various universities and research organizations both nationally and internationally.
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Gemcitabine Hydrochloride

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Cipla

India
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Cipla

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GEMCITABINE HYDROCHLORIDE

About the Company : Cipla is a global pharmaceutical company whose goal is ensuring no patient shall be denied access to high quality & affordable medicine and support. Mission: Cipla’s mission i...

Cipla is a global pharmaceutical company whose goal is ensuring no patient shall be denied access to high quality & affordable medicine and support. Mission: Cipla’s mission is to be a leading global healthcare company which uses technology and innovation to meet everyday needs of all patients. Since inception in 1935, caring has been at the core of everything we do at Cipla. For patients, caring is a promise that we will do whatever it takes to ensure they have continued access to the highest quality medicines at affordable prices; whether a disease affects millions or just a few hundreds.
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Gemcitabine

About the Company : Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 years of development, ...

Fujian South Pharmaceutical Co., Ltd. (Southern Pharmaceutical) was established in September 2001 and is located in Mingxi County, Fujian Province. After 16 years of development, Nanfang Pharmaceutical has grown into a major domestic manufacturer of anti-tumor raw materials and intermediates, and has expanded to non-anti-tumor drugs. Using the company's accumulated rich experience and first-class technology in plant extraction, the company's product line has been expanded to the field of plant-derived products.
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Gemcitabine Hydrochloride

About the Company : Hoventa Pharma is in the business of manufacturing APIs for over three decades.We offer various kinds of services in addition to supplies of APIs, we undertake long-term contracts ...

Hoventa Pharma is in the business of manufacturing APIs for over three decades.We offer various kinds of services in addition to supplies of APIs, we undertake long-term contracts for manufacturing intermediates and development of new Active Pharmaceutical Ingredients as per your requirement. We have a sharp focus on giving value added services to our customers cost effectively. We are supplying APIs to the global pharmaceutical companies in India and abroad since the last 3 decades. Some of our major customers operate in India and export to their products to other countries.
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Laurus Labs

India
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Laurus Labs

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Gemcitabine Hydrochloride

About the Company : Laurus Labs is a leading research and development-driven pharmaceutical company in India. The company has grown consistently to become one of the leading manufacturers of Active Ph...

Laurus Labs is a leading research and development-driven pharmaceutical company in India. The company has grown consistently to become one of the leading manufacturers of Active Pharmaceutical Ingredients (APIs) for anti-retroviral (ARV) and Hepatitis C. Laurus Labs also manufactures APIs in oncology and other therapeutic areas. Its strategic and early investments in R&D and manufacturing infrastructure have enabled it to become one of the leading suppliers of APIs in the ARV therapeutic area. Out of Ten largest generic pharmaceutical companies in the world, by revenues, are our customers.
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Gemcitabine

About the Company : Established in 2010, Mac-Chem is a NMM Group company. Mac-Chem is focused on oncology and other niche specialty APIs. It supplies quality APIs to the top 15 oncology players in Ind...

Established in 2010, Mac-Chem is a NMM Group company. Mac-Chem is focused on oncology and other niche specialty APIs. It supplies quality APIs to the top 15 oncology players in India. It is also the sole manufacturer of some of the molecules in the oncology segment and general segment. The company’s investments are mostly geared toward exports, especially to regulated markets. Mac-Chem has a cGMP-compliant manufacturing facility near Mumbai in India. The company’s facility is USFDA, EDQM, COFEPRIS, ANVISA, MFDS-Korea, WHO-GMP-approved and ISO-certified. Mac-Chem enjoys a global reach, serving more than 40 countries.
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API Reference Price

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04-Jan-2021
28-Oct-2024
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Drugs in Development

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Details:

Loqtorzi (toripalimab-tpzi) is an anti-PD-1 monoclonal antibody approved in combination with cisplatin and gemcitabine for first-line treatment of metastatic or recurrent nasopharyngeal carcinoma.


Lead Product(s): Toripalimab,Cisplatin,Gemcitabine

Therapeutic Area: Oncology Brand Name: Loqtorzi

Study Phase: Phase IIIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 18, 2024

Dr Reddy Company Banner

01

Lead Product(s) : Toripalimab,Cisplatin,Gemcitabine

Therapeutic Area : Oncology

Highest Development Status : Phase III

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : Loqtorzi (toripalimab-tpzi) is an anti-PD-1 monoclonal antibody approved in combination with cisplatin and gemcitabine for first-line treatment of metastatic or recurrent nasopharyngeal carcinoma.

Brand Name : Loqtorzi

Molecule Type : Large molecule

Upfront Cash : Not Applicable

April 18, 2024

Dr Reddy Company Banner

Details:

IMM-1-104 is an oral, once-daily deep cyclic inhibitor, small molecule drug. It is being evaluated for pancreatic ductal adenocarcinoma with gemcitabine and nab-paclitaxel.


Lead Product(s): IMM-1-104,Gemcitabine,Paclitaxel

Therapeutic Area: Oncology Brand Name: IMM-1-104

Study Phase: Phase I/ Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 15, 2024

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02

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : IMM-1-104 is an oral, once-daily deep cyclic inhibitor, small molecule drug. It is being evaluated for pancreatic ductal adenocarcinoma with gemcitabine and nab-paclitaxel.

Brand Name : IMM-1-104

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 15, 2024

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Details:

Loqtorzi (toripalimab) is an approved anti-PD-1 monoclonal antibody, in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic nasopharyngeal carcinoma.


Lead Product(s): Toripalimab,Cisplatin,Gemcitabine

Therapeutic Area: Oncology Brand Name: Loqtorzi

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: TopAlliance Biosciences

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 15, 2024

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03

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : Loqtorzi (toripalimab) is an approved anti-PD-1 monoclonal antibody, in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic nasopharyngeal carcinoma.

Brand Name : Loqtorzi

Molecule Type : Large molecule

Upfront Cash : Not Applicable

October 15, 2024

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Details:

GP-2250 (misetionamide) is being evaluated in the early-stage clinical trial studies in combination with gemcitabine for the treatment of panmcreatic cancer.


Lead Product(s): Misetionamide,Gemcitabine

Therapeutic Area: Oncology Brand Name: GP-2250

Study Phase: Phase IProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 09, 2024

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04

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : GP-2250 (misetionamide) is being evaluated in the early-stage clinical trial studies in combination with gemcitabine for the treatment of panmcreatic cancer.

Brand Name : GP-2250

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 09, 2024

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Details:

TAR-200 (gemcitabine) is a DNA polymerase inhibitor. It is under phase 2 clinical evaluation in combination with Cetrelimab for the treatment of BCG unresponsive non-muscle-invasive bladder cancer.


Lead Product(s): Gemcitabine,Cetrelimab

Therapeutic Area: Oncology Brand Name: TAR-200

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 07, 2024

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05

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Lead Product(s) : Gemcitabine,Cetrelimab

Therapeutic Area : Oncology

Highest Development Status : Phase III

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : TAR-200 (gemcitabine) is a DNA polymerase inhibitor. It is under phase 2 clinical evaluation in combination with Cetrelimab for the treatment of BCG unresponsive non-muscle-invasive bladder cancer.

Brand Name : TAR-200

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 07, 2024

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Details:

The net proceeds will be used to fund the clinical development of the company's lead product VCN-01, which is being evaluated for the treatment of Metastatic Pancreatic Ductal Adenocarcinoma.


Lead Product(s): VCN-01,Paclitaxel,Gemcitabine

Therapeutic Area: Oncology Brand Name: VCN-01

Study Phase: Phase IIProduct Type: Large molecule

Sponsor: Alliance Global Partners

Deal Size: $2.5 million Upfront Cash: Undisclosed

Deal Type: Public Offering September 26, 2024

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06

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Lead Product(s) : VCN-01,Paclitaxel,Gemcitabine

Therapeutic Area : Oncology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Alliance Global Partners

Deal Size : $2.5 million

Deal Type : Public Offering

Details : The net proceeds will be used to fund the clinical development of the company's lead product VCN-01, which is being evaluated for the treatment of Metastatic Pancreatic Ductal Adenocarcinoma.

Brand Name : VCN-01

Molecule Type : Large molecule

Upfront Cash : Undisclosed

September 26, 2024

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Details:

Loqtorzi (toripalimab) is an approved anti-PD-1 monoclonal antibody, in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic nasopharyngeal carcinoma.


Lead Product(s): Toripalimab,Cisplatin,Gemcitabine

Therapeutic Area: Oncology Brand Name: Loqtorzi

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 24, 2024

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07

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : Loqtorzi (toripalimab) is an approved anti-PD-1 monoclonal antibody, in combination with cisplatin and gemcitabine for the first-line treatment of adults with metastatic nasopharyngeal carcinoma.

Brand Name : Loqtorzi

Molecule Type : Large molecule

Upfront Cash : Not Applicable

September 24, 2024

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Details:

VCN-01 is being evaluated in combination with standard-of-care (SoC) chemotherapy (gemcitabine/nab-paclitaxel) as a first line therapy for patients with pancreatic ductal adenocarcinoma (PDAC).


Lead Product(s): VCN-01,Paclitaxel,Gemcitabine

Therapeutic Area: Oncology Brand Name: VCN-01

Study Phase: Phase IIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 23, 2024

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08

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : VCN-01 is being evaluated in combination with standard-of-care (SoC) chemotherapy (gemcitabine/nab-paclitaxel) as a first line therapy for patients with pancreatic ductal adenocarcinoma (PDAC).

Brand Name : VCN-01

Molecule Type : Large molecule

Upfront Cash : Not Applicable

September 23, 2024

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Details:

AMP945 (narmafotinib) is a novel focal adhesion kinase (FAK) inhibitor. It is being evaluated in precliical studies for the treatment of patients with pancreatic cancer.


Lead Product(s): AMP945,Gemcitabine,Paclitaxel

Therapeutic Area: Oncology Brand Name: AMP945

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 19, 2024

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09

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Details : AMP945 (narmafotinib) is a novel focal adhesion kinase (FAK) inhibitor. It is being evaluated in precliical studies for the treatment of patients with pancreatic cancer.

Brand Name : AMP945

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 19, 2024

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Details:

TAR-200 (gemcitabine) is a DNA polymerase inhibitor. It is under phase 2 clinical evaluation in combination with Cetrelimab for the treatment of BCG unresponsive non-muscle-invasive bladder cancer.


Lead Product(s): Gemcitabine,Cetrelimab

Therapeutic Area: Oncology Brand Name: TAR-200

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 15, 2024

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10

American Pharma Summit
Not Confirmed
American Pharma Summit
Not Confirmed

Lead Product(s) : Gemcitabine,Cetrelimab

Therapeutic Area : Oncology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : TAR-200 (gemcitabine) is a DNA polymerase inhibitor. It is under phase 2 clinical evaluation in combination with Cetrelimab for the treatment of BCG unresponsive non-muscle-invasive bladder cancer.

Brand Name : TAR-200

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 15, 2024

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INTERMEDIATES SUPPLIERS

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01

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 122111-01-7

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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02

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 134877-42-2

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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03

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 134790-39-9

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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04

Compamed
Not Confirmed
arrow
Compamed
Not Confirmed
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CAS Number : 122111-01-7

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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05

Compamed
Not Confirmed
arrow
Compamed
Not Confirmed
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CAS Number : 134877-42-2

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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06

Compamed
Not Confirmed
arrow
Compamed
Not Confirmed
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CAS Number : 134790-39-9

End Use API : Gemcitabine

About The Company : Beijing Lunarsun pharma is a professional manufacturer of API and intermediates. The factory is approved by US FDA. According to EU and US FDA's requirement, we...

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07

Dasami Lab

India
Compamed
Not Confirmed
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Dasami Lab

India
Compamed
Not Confirmed
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CAS Number : 122111-01-7

End Use API : Gemcitabine

About The Company : Dasami Lab Private Limited incorporated with MCA on 24 July 2015. The Dasami Lab Private Limited is listed in the class of pvtltd company and classified as Non ...

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08

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 122111-01-7

End Use API : Gemcitabine

About The Company : Fuan Pharmaceutical (Group) Co., Ltd. was established on February 25, 2004. The company is located in Chongqing Changshou Economic and Technological Development...

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09

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 122111-11-9

End Use API : Gemcitabine

About The Company : Fuan Pharmaceutical (Group) Co., Ltd. was established on February 25, 2004. The company is located in Chongqing Changshou Economic and Technological Development...

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10

Compamed
Not Confirmed
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Compamed
Not Confirmed
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CAS Number : 134790-39-9

End Use API : Gemcitabine

About The Company : Fuan Pharmaceutical (Group) Co., Ltd. was established on February 25, 2004. The company is located in Chongqing Changshou Economic and Technological Development...

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - EQ 1GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 1GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20509

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DOSAGE - INJECTABLE;INJECTION - EQ 200MG BASE...DOSAGE - INJECTABLE;INJECTION - EQ 200MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20509

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1200MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1200MG BASE/120ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1300MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1300MG BASE/130ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1400MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1400MG BASE/140ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1500MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1500MG BASE/150ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1600MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1600MG BASE/160ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1700MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1700MG BASE/170ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1800MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1800MG BASE/180ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 1900MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 1900MG BASE/190ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 2000MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 2000MG BASE/200ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 2200MG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 2200MG BASE/220ML (EQ 10MG BASE/ML)

USFDA APPLICATION NUMBER - 208313

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Finished Drug Prices

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01

Brand Name : Gemcitabine Accord

United Kingdom
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American Pharma Summit
Not Confirmed

Brand Name : Gemcitabine Accord

United Kingdom
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American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 100 mg/ml

Price Per Pack (Euro) : 43.494

Published in :

Country : Norway

RX/OTC/DISCN :

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02

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 100 mg/ml

Price Per Pack (Euro) : 197.43

Published in :

Country : Norway

RX/OTC/DISCN :

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03

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 100 mg/ml

Price Per Pack (Euro) : 293.77

Published in :

Country : Norway

RX/OTC/DISCN :

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04

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabine Accord

United Kingdom
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 100 mg/ml

Price Per Pack (Euro) : 390.10

Published in :

Country : Norway

RX/OTC/DISCN :

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05

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 38 mg/ml

Price Per Pack (Euro) : 43.494

Published in :

Country : Norway

RX/OTC/DISCN :

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06

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 38 mg/ml

Price Per Pack (Euro) : 197.43

Published in :

Country : Norway

RX/OTC/DISCN :

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07

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Hospira

U.S.A
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 38 mg/ml

Price Per Pack (Euro) : 390.10

Published in :

Country : Norway

RX/OTC/DISCN :

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08

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 40 mg/ml

Price Per Pack (Euro) : 43.494

Published in :

Country : Norway

RX/OTC/DISCN :

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09

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 40 mg/ml

Price Per Pack (Euro) : 197.43

Published in :

Country : Norway

RX/OTC/DISCN :

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10

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Brand Name : Gemcitabin Actavis

Ireland
arrow
American Pharma Summit
Not Confirmed

Gemcitabine

Dosage Form : Concentrate to the infusion flui...

Dosage Strength : 40 mg/ml

Price Per Pack (Euro) : 390.10

Published in :

Country : Norway

RX/OTC/DISCN :

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