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Chemistry

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Also known as: 1075236-89-3, Gsk2140944, Gsk-2140944, Gsk 2140944, Dvf0pr037d, 3h,8h-2a,5,8a-triazaacenaphthylene-3,8-dione, 2-((4-(((3,4-dihydro-2h-pyrano(2,3-c)pyridin-6-yl)methyl)amino)-1-piperidinyl)methyl)-1,2-dihydro-, (2r)-
Molecular Formula
C24H28N6O3
Molecular Weight
448.5  g/mol
InChI Key
PZFAZQUREQIODZ-LJQANCHMSA-N
FDA UNII
DVF0PR037D

Gepotidacin
Gepotidacin has been used in trials studying the treatment of Gonorrhea, Infections, Bacterial, and Infections, Respiratory Tract.
1 2D Structure

Gepotidacin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3R)-3-[[4-(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione
2.1.2 InChI
InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1
2.1.3 InChI Key
PZFAZQUREQIODZ-LJQANCHMSA-N
2.1.4 Canonical SMILES
C1CC2=CC(=NC=C2OC1)CNC3CCN(CC3)CC4CN5C(=O)C=CC6=C5N4C(=O)C=N6
2.1.5 Isomeric SMILES
C1CC2=CC(=NC=C2OC1)CNC3CCN(CC3)C[C@@H]4CN5C(=O)C=CC6=C5N4C(=O)C=N6
2.2 Other Identifiers
2.2.1 UNII
DVF0PR037D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Gsk2140944

2.3.2 Depositor-Supplied Synonyms

1. 1075236-89-3

2. Gsk2140944

3. Gsk-2140944

4. Gsk 2140944

5. Dvf0pr037d

6. 3h,8h-2a,5,8a-triazaacenaphthylene-3,8-dione, 2-((4-(((3,4-dihydro-2h-pyrano(2,3-c)pyridin-6-yl)methyl)amino)-1-piperidinyl)methyl)-1,2-dihydro-, (2r)-

7. (2r)-2-[(4-{[(3,4-dihydro-2h-pyrano[2,3-c]pyridin- 6-yl)methyl]amino}piperidin-1-yl)methyl]-1,2-dihydro- 3h,8h-2a,5,8a-triazaacenaphthylene-3,8-dione

8. (3~{r})-3-[[4-(3,4-dihydro-2~{h}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione

9. (3r)-3-[[4-(3,4-dihydro-2h-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione

10. Gepotidacin [usan:inn]

11. Unii-dvf0pr037d

12. 3h,8h-2a,5,8a-triazaacenaphthylene-3,8-dione, 2-[[4-[[(3,4-dihydro-2h-pyrano[2,3-c]pyridin-6-yl)methyl]amino]-1-piperidinyl]methyl]-1,2-dihydro-, (2r)-

13. Jhn

14. Gepotidacin [inn]

15. Gepotidacin (usan/inn)

16. Gepotidacin [usan]

17. Gepotidacin [who-dd]

18. Schembl3332319

19. Chembl3317856

20. Gtpl10817

21. Dtxsid501028208

22. Bdbm50050549

23. Gsk 2140944e

24. Cs-6531

25. Db12134

26. Hy-16742

27. D10878

28. A857306

29. Q19597285

2.4 Create Date
2008-12-15
3 Chemical and Physical Properties
Molecular Weight 448.5 g/mol
Molecular Formula C24H28N6O3
XLogP30.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass448.22228878 g/mol
Monoisotopic Mass448.22228878 g/mol
Topological Polar Surface Area90.4 Ų
Heavy Atom Count33
Formal Charge0
Complexity893
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of uncomplicated urogenital gonorrhea


Treatment of uncomplicated urinary tract infections


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Topoisomerase Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASES. (See all compounds classified as Topoisomerase Inhibitors.)


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ABOUT THIS PAGE

Gepotidacin Manufacturers

A Gepotidacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gepotidacin, including repackagers and relabelers. The FDA regulates Gepotidacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gepotidacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gepotidacin Suppliers

A Gepotidacin supplier is an individual or a company that provides Gepotidacin active pharmaceutical ingredient (API) or Gepotidacin finished formulations upon request. The Gepotidacin suppliers may include Gepotidacin API manufacturers, exporters, distributors and traders.

Gepotidacin GMP

Gepotidacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gepotidacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gepotidacin GMP manufacturer or Gepotidacin GMP API supplier for your needs.

Gepotidacin CoA

A Gepotidacin CoA (Certificate of Analysis) is a formal document that attests to Gepotidacin's compliance with Gepotidacin specifications and serves as a tool for batch-level quality control.

Gepotidacin CoA mostly includes findings from lab analyses of a specific batch. For each Gepotidacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gepotidacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Gepotidacin EP), Gepotidacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gepotidacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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