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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF, $ API Reference Price

2 API Suppliers
2 USDMF
$ API Reference Price

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

$ 13,667

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Chemistry

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Also known as: 7440-56-4, Ge, Germanium powder, Germanium(2+), 13572-99-1, 00072j7xws

Molecular Formula

Molecular Weight

72.63 g/mol

InChI Key

GNPVGFCGXDBREM-UHFFFAOYSA-N

FDA UNII

00072J7XWS

A rare metal element with a blue-gray appearance and atomic symbol Ge, atomic number 32, and atomic weight 72.63.

1 2D Structure

Germanium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

germanium

2.1.2 InChI

InChI=1S/Ge

2.1.3 InChI Key

GNPVGFCGXDBREM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

[Ge]

2.2 Other Identifiers

2.2.1 UNII

00072J7XWS

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 7440-56-4

2. Ge

3. Germanium Powder

4. Germanium(2+)

5. 13572-99-1

6. 00072j7xws

7. Mfcd00085310

8. Germylidyne

9. Germanium Optical Window, 50.8mm (2.0in) Dia X 2mm (0.08in) Thick

10. Hsdb 2118

11. Germanium, Chips, 99.999% Trace Metals Basis

12. Germanium, Metal Powder

13. Einecs 231-164-3

14. Germanio

15. Germylium

16. Germanium Atom

17. Unii-00072j7xws

18. Germanium Wafer

19. Germanium, Disks, 15mm, Thickness 1.0mm, Polycrystalline, 100%

20. Germanium Nanorods

21. Germanium Nanowires

22. Germanium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (111) Orientation, +/-0.5 Degrees

23. Germanium Nanopowder

24. Germanium Nanoprisms

25. Germanium(2+) Ion

26. Germanium(ii) Cation

27. Germanium Pieces, 5n

28. Germanium Nanoparticles

29. Tetrahydrogermane

30. Germanium [mi]

31. Germane [mi]

32. Germanium [hsdb]

33. Germanium [vandf]

34. Ultra Thin Germanium Foil

35. Germanium Metallicum

36. 32ge

37. Germanium, Elemental

38. Germanium [who-dd]

39. Germanium Nanorods Properties

40. Germanium Ingot, Zone Refined

41. Germanium Nanowires Properties

42. Germanium Powder, -100 Mesh

43. Germanium(4+) Hydride

44. Dtxsid7052521

45. Dtxsid8052483

46. Chebi:30441

47. Chebi:30549

48. Chebi:30556

49. Ge(2+)

50. Ge(4-)

51. Dtxsid30422913

52. Germanium Hydride (geh4)

53. Dtxsid901318637

54. Akos015902739

55. Akos025295742

56. Cobalt Oxide (coo) Sputtering Targets

57. Un-2192

58. Germanium Pieces, 2cm (0.8in) & Down

59. Q867

60. Germanium Pieces, 3-9mm (0.1-0.4in)

61. Germanium Pieces, 3.2mm (0.125in) And Down

62. Germanium Pieces, 2cm (0.8in) & Down, Puratronic?

63. Q27113859

64. Q27113865

65. Germanium Rod, Polycrystalline, 6.35mm (0.25in) Dia

66. Germanium, Plasma Standard Solution, Specpure, Ge 10g/ml

67. Germanium, Aas Standard Solution, Specpure?, Ge 1000?g/ml

68. Germanium, Powder, -100 Mesh, >=99.99% Trace Metals Basis

69. Germanium, Powder, -100 Mesh, >=99.999% Trace Metals Basis

70. Germanium, Rod, 6mm, Diameter 6.0mm, Single Crystal, 100%

71. Germanium, Disks, 20mm, Thickness 1.0mm, Single Crystal, 100%

72. Germanium, Plasma Standard Solution, Specpure?, Ge 10,000?g/ml

73. Germanium, Rod, 2.0 Mm Diameter, Length 50 Mm, Purity 99.999%

74. Germanium Optical Window, 25.4mm (1.0in) Dia X 1mm (0.04in) Thick

75. Germanium Optical Window, 25.4mm (1.0in) Dia X 2mm (0.08in) Thick

76. Germanium Optical Window, 50.8mm (2.0in) Dia X 1mm (0.04in) Thick

77. Germanium, Lump, 10 Mm Max. Lump Size, Weight 100 G, Purity 99.999%

78. Germanium, Lump, 10 Mm Max. Lump Size, Weight 20 G, Purity 99.999%

79. Germanium, Lump, 10 Mm Max. Lump Size, Weight 50 G, Purity 99.999%

80. Germanium, Lump, 12.5 Mm Max. Lump Size, Weight 100 G, Purity 99.999%

81. Germanium, Lump, 12.5 Mm Max. Lump Size, Weight 20 G, Purity 99.999%

82. Germanium, Lump, 12.5 Mm Max. Lump Size, Weight 50 G, Purity 99.999%

83. Germanium, Lump, 25 Mm Max. Lump Size, Weight 100 G, Purity 99.999%

84. Germanium, Lump, 25 Mm Max. Lump Size, Weight 20 G, Purity 99.999%

85. Germanium, Lump, 25 Mm Max. Lump Size, Weight 50 G, Purity 99.999%

86. Germanium, Rod, 25mm, Diameter 2.0mm, Polycrystalline, N-type, 99.999%

87. Germanium, Rod, 25mm, Diameter 5mm, Polycrystalline, N-type, 99.999%

88. Germanium, Rod, 45mm, Diameter 2.0mm, Polycrystalline, N-type, 99.999%

89. Germanium, Rod, 50mm, Diameter 5mm, Polycrystalline, N-type, 99.999%

90. Germanium, Sheet, 10x10mm, Thickness 0.10mm, Polycrystalline, 99.999%

91. Germanium, Sheet, 10x10mm, Thickness 0.25mm, Polycrystalline, 99.999%

92. Germanium, Sheet, 10x10mm, Thickness 0.5mm, Single Crystal, -111, 100%

93. Germanium, Sheet, 10x10mm, Thickness 0.6mm, Single Crystal, -111, 100%

94. Germanium, Sheet, 25x25mm, Thickness 1.0mm, Polycrystalline, 99.999%

95. Germanium, Sheet, 25x25mm, Thickness 1.0mm, Single Crystal, 99.999%

96. Germanium, Sheet, 25x25mm, Thickness 3.0mm, Polycrystalline, 99.999%

97. Germanium, Sheet, 4x4mm, Thickness 0.05mm, Polycrystalline, 99.999%

98. Germanium, Sheet, 50x50mm, Thickness 0.5mm, Single Crystal, 99.999%

99. Germanium, Sheet, 50x50mm, Thickness 1.0mm, Polycrystalline, 99.999%

100. Germanium, Sheet, 50x50mm, Thickness 3.0mm, Polycrystalline, 99.999%

101. Germanium, Sheet, 6x6mm, Thickness 1.0mm, Polycrystalline, 99.999%

102. Germanium, Sheet, 7x24mm, Thickness 1.0mm, Polycrystalline, 99.999%

103. Germanium, Sheet, Thickness 0.5 Mm, Diameter 50.8 Mm, Purity 99.999%

104. Germanium, Sheet, Thickness 2.0 Mm, Size 10 X 24 Mm, Purity 99.999%

105. Germanium, Plasma Standard Solution, Specpure?, Ge 1000?g/ml, (nh4)2gef6 In H2o/trace F-

106. Germanium, Plasma Standard Solution, Specpure?, Ge 1000?g/ml, Ge In 5% Hno3/tr. Hf

107. Germanium, Powder, 150 Max. Part. Size (micron), Weight 100 G, Purity 99.999%

108. Germanium, Powder, 150 Max. Part. Size (micron), Weight 50 G, Purity 99.999%

109. Germanium, Powder, Max. Particle Size 150 Micron, Weight 20 G, Purity 99.999%

110. 33272-98-9

111. Germanium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (100) Orientation, +/-0.5 Degrees

112. Germanium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (110) Orientation, +/-0.5 Degrees

113. Germanium, Microfoil, 25x25mm, Thinness 0.25mum, Specific Density 166.3mug/cm2, 6 Micron Aluminum Permanent Support, 100%

114. Germanium, Microfoil, 25x25mm, Thinness 0.5mum, Specific Density 333mug/cm2, 6 Micron Aluminum Permanent Support, 100%

115. Germanium, Microfoil, 50x50mm, Thinness 0.25mum, Specific Density 166.3mug/cm2, 6 Micron Aluminum Permanent Support, 100%

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	Ge
Molecular Weight	72.63 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	0
Exact Mass	73.9211778 g/mol
Monoisotopic Mass	73.9211778 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	1
Formal Charge	0
Complexity	0
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Absorption, Distribution and Excretion

ABSORPTION FROM THE GASTRO-INTESTINAL TRACT IS RAPID...76.3% OF THE ADMINISTERED DOSE WITHIN 4 HR & 96.4% AFTER 8 HR. BY SC, IM, OR IP INJECTION... ABSORPTION IS RAPID & PRACTICALLY COMPLETE. AFTER 1 HR 93.8% OF IM DOSE HAD DISAPPEARED FROM THE SITE OF INJECTION...

Browning, E. Toxicity of Industrial Metals. 2nd ed. New York: Appleton-Century-Crofts, 1969., p. 159

...IM DOSE...NO GERMANIUM COULD BE RECOVERED FROM ANY OF THE MUSCLES INJECTED AFTER 7 HR. IT ENTERS THE BLOOD STREAM, AND IS TRANSPORTED, UNBOUND TO PLASMA PROTEINS IN PLASMA, & IS CARRIED RAPIDLY TO THE TISSUES, WHERE IT IS DEPOSITED AMONG ALL THE ORGANS.

Browning, E. Toxicity of Industrial Metals. 2nd ed. New York: Appleton-Century-Crofts, 1969., p. 159

IN MICE CONTINUOUS FEEDING OF GERMANIUM CAUSES ACCUMULATION IN THE SPLEEN; HOWEVER SAME IS NOT TRUE FOR RATS. INHALATION EXPOSURE OF RATS TO GERMANIUM AND GERMANIUM OXIDE ... REVEALED RAPID REMOVAL FROM THE LUNG TISSUE.

Doull, J., C.D. Klaassen, and M. D. Amdur (eds.). Casarett and Doull's Toxicology. 2nd ed. New York: Macmillan Publishing Co., 1980., p. 444

INORGANIC GERMANIUM ... READILY ABSORBED FOLLOWING A FEW MG ORAL, SUBCUTANEOUS, INTRAMUSCULAR, OR INTRAPERITONEAL DOSES IN THE RAT. BLOOD LEVELS ATTAINED... LESS THAN 10 UG/G WITHIN A FEW HOURS AFTER ADMIN; FOLLOWING SINGLE SMALL DOSE, GERMANIUM LEAVES BLOOD STREAM WITHIN FEW HR. /GERMANIUM CMPD/

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1046

For more Absorption, Distribution and Excretion (Complete) data for GERMANIUM (13 total), please visit the HSDB record page.

4.2 Biological Half-Life

Inadequate data, but estimated at 1.5 days whole-body retention time in rats; [Nordberg, p. 557]

Nordberg - Nordberg GF, Fowler BA, Nordberg M (eds). Handbook on the Toxicology of Metals, 4th Ed. Boston: Elsevier, 2015., p. 557

FOR RATS BIOL T/2 CAN BE...EST AS 1.5 DAYS FOR WHOLE BODY RETENTION, 2 DAYS FOR LIVER & 4.5 DAYS FOR KIDNEY.

Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. II:260

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API Reference Price

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