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Chemistry

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Also known as: Iridus, Ls 121, Diethyl-[2-[2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoyl]oxyethyl]azanium;2-hydroxy-2-oxoacetate, 5adb8d9388, Naphtidrofuryl oxalate, Einecs 221-703-0
Molecular Formula
C26H35NO7
Molecular Weight
473.6  g/mol
InChI Key
SSAJNPNVUYMUCI-UHFFFAOYSA-N

Gevatran
A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
1 2D Structure

Gevatran

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
diethyl-[2-[2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoyl]oxyethyl]azanium;2-hydroxy-2-oxoacetate
2.1.2 InChI
InChI=1S/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6)
2.1.3 InChI Key
SSAJNPNVUYMUCI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC[NH+](CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32.C(=O)(C(=O)[O-])O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Artocoron

2. Azunaftil

3. Di Actane

4. Di-actane

5. Dusodril

6. Gvatran

7. Ls 121

8. Ls-121

9. Ls121

10. Nafronyl

11. Nafronyl Oxalate

12. Nafronyloxalate

13. Nafti Puren

14. Nafti Ratiopharm

15. Nafti Von Ct

16. Nafti-puren

17. Nafti-ratiopharm

18. Naftidrofuryl

19. Naftifurin Oxalate

20. Naftilong

21. Naftilux

22. Naftiratiopharm

23. Oxalate, Nafronyl

24. Oxalate, Naftifurin

25. Praxilne

2.2.2 Depositor-Supplied Synonyms

1. Iridus

2. Ls 121

3. Diethyl-[2-[2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoyl]oxyethyl]azanium;2-hydroxy-2-oxoacetate

4. 5adb8d9388

5. Naphtidrofuryl Oxalate

6. Einecs 221-703-0

7. Nsc 225233

8. Unii-5adb8d9388

9. 2-(diethylamino)ethyl Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate Oxalate (1:1)

10. 2-furanpropanoic Acid, Tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl Ester, Ethanedioate (1:1)

11. 2-furanpropionic Acid, Tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl Ester, Oxalate (1:1)

12. Diethyl(2-(2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy)ethyl)ammonium Hydrogen Oxalate

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 473.6 g/mol
Molecular Formula C26H35NO7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass473.24135246 g/mol
Monoisotopic Mass473.24135246 g/mol
Topological Polar Surface Area117 Ų
Heavy Atom Count34
Formal Charge0
Complexity543
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


ABOUT THIS PAGE

Gevatran Manufacturers

A Gevatran manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gevatran, including repackagers and relabelers. The FDA regulates Gevatran manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gevatran API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gevatran Suppliers

A Gevatran supplier is an individual or a company that provides Gevatran active pharmaceutical ingredient (API) or Gevatran finished formulations upon request. The Gevatran suppliers may include Gevatran API manufacturers, exporters, distributors and traders.

click here to find a list of Gevatran suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Gevatran CEP

A Gevatran CEP of the European Pharmacopoeia monograph is often referred to as a Gevatran Certificate of Suitability (COS). The purpose of a Gevatran CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Gevatran EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Gevatran to their clients by showing that a Gevatran CEP has been issued for it. The manufacturer submits a Gevatran CEP (COS) as part of the market authorization procedure, and it takes on the role of a Gevatran CEP holder for the record. Additionally, the data presented in the Gevatran CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Gevatran DMF.

A Gevatran CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Gevatran CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Gevatran suppliers with CEP (COS) on PharmaCompass.

Gevatran GMP

Gevatran Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gevatran GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gevatran GMP manufacturer or Gevatran GMP API supplier for your needs.

Gevatran CoA

A Gevatran CoA (Certificate of Analysis) is a formal document that attests to Gevatran's compliance with Gevatran specifications and serves as a tool for batch-level quality control.

Gevatran CoA mostly includes findings from lab analyses of a specific batch. For each Gevatran CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gevatran may be tested according to a variety of international standards, such as European Pharmacopoeia (Gevatran EP), Gevatran JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gevatran USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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