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1. 28704-27-0
2. Cop-1
3. (2s)-2-amino-3-(4-hydroxyphenyl)propanoic Acid;(2s)-2-aminopentanedioic Acid;(2s)-2-aminopropanoic Acid;(2s)-2,6-diaminohexanoic Acid
4. Dtxsid50182865
| Molecular Weight | 563.6 g/mol |
|---|---|
| Molecular Formula | C23H41N5O11 |
| Hydrogen Bond Donor Count | 11 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 13 |
| Exact Mass | 563.28025714 g/mol |
| Monoisotopic Mass | 563.28025714 g/mol |
| Topological Polar Surface Area | 337 Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 0 |
| Complexity | 488 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 4 |
For reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.
FDA Label
Glatiramer acetate was originally designed to mimic a protein in myelin, called myelin basic protein, with the intention of inducing EAE (an animal model of MS). Quite to the contrary, it was found to suppress the disease and as a result came to be trialed in human MS. There is some evidence that Glatiramer acetate converts the body's immune response from a Th1 type to a Th2 one, promotes suppressor T cells or acts as an altered peptide ligand. Studies in animals and in vitro systems suggest that upon its administration, glatiramer acetate-specific suppressor T-cells are induced and activated in the periphery. Some fraction of the injected material, either intact or partially hydrolyzed, is presumed to enter the lymphatic circulation, enabling it to reach regional lymph nodes, and some may enter the systemic circulation intact.
Hydrolyzed by proteases
Glatiramer acetate (GA) exhibits strong and promiscuous binding to MHC molecules (HLA DRB1* variants) and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression. Furthermore, the GA-specific cells in the brain express the anti-inflammatory cytokines IL-10 and transforming growth factor beta, in addition to brain-derived neurotrophic factor, whereas they do not express the inflammatory cytokine IFN-gamma. Recent evidence also suggests that Glatiramer acetate directly inhibits dendritic cells and monocytes - both of which are circulating antigen presenting cells.
API SUPPLIERS
Tofigh Daru develops & synthesizes a diverse range of APIs in Anticancer, Narcotics, Cardiovascular to Immunomodulatory Segments.
GDUFA
DMF Review : Reviewed
Rev. Date : 2015-01-05
Pay. Date : 2014-06-09
DMF Number : 26489
Submission : 2012-09-27
Status : Active
Type : II
NDC Package Code : 41524-0004
Start Marketing Date : 2012-09-06
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1g/g)
Marketing Category : BULK INGREDIENT
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USDMF
GDUFA
DMF Review : Complete
Rev. Date : 2015-01-05
Pay. Date : 2014-06-09
DMF Number : 26489
Submission : 2012-09-27
Status : Active
Type : II
FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]NDC API
NDC Package Code : 41524-0004
Start Marketing Date : 2012-09-06
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1g/g)
Marketing Category : BULK INGREDIENT
FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]Listed Suppliers
Tofigh Daru develops & synthesizes a diverse range of APIs in Anticancer, Narcotics, Cardiovascular to Immunomodulatory Segments.
About the Company : Tofigh Daru (TODACO) belongs to the Tamin Pharmaceutical Investment Company, the biggest pharmaceutical holding in Iran. TODACO develops novel APIs in therapeutic categories like A...
About the Company : Hybio is a hi-tech enterprise specializing in the R&D and manufacturing of diverse peptide products. Founded in 1998, after decades of effort, we have grown to be one of the larges...
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API Imports and Exports
| Importing Country | Total Quantity (KGS) |
Average Price (USD/KGS) |
Number of Transactions |
|---|
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Global Sales Information
Finished Drug Prices
RX/OTC/DISCN : Class A
Dosage Form : Glatiramer 20Mg 28 Joined The Pa...
Dosage Strength : 28 SYRINGES SC 20 mg/ml 1 ml
Price Per Pack (Euro) : 1,206.17
Published in :
Country : Italy
RX/OTC/DISCN : Class A
RX/OTC/DISCN : Class A
Dosage Form : Glatiramer 40Mg 12 Units Parente...
Dosage Strength : 12 SYRINGES SC 40 mg/ml 1 ml
Price Per Pack (Euro) : 1,206.17
Published in :
Country : Italy
RX/OTC/DISCN : Class A
RX/OTC/DISCN :
Dosage Form : Solution For Injection
Dosage Strength : 20 mg/ml
Price Per Pack (Euro) : 1,145.86
Published in :
Country : Italy
RX/OTC/DISCN :
RX/OTC/DISCN :
Dosage Form : Solution For Injection In Pre-Fi...
Dosage Strength : 40 mg/ml
Price Per Pack (Euro) : 859.4
Published in :
Country : Italy
RX/OTC/DISCN :
RX/OTC/DISCN :
Dosage Form : Solution For Injection In Pre-Fi...
Dosage Strength : 20 mg/ml
Price Per Pack (Euro) : 893.77
Published in :
Country : Italy
RX/OTC/DISCN :
RX/OTC/DISCN :
Dosage Form : Solution For Injection In Pre-Fi...
Dosage Strength : 40 mg/ml
Price Per Pack (Euro) : 1,145.86
Published in :
Country : Italy
RX/OTC/DISCN :
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