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Glucose

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ACTIVE PHARMA INGREDIENTS

35 API Suppliers, 10 USDMF, 7 CEP/COS, 12 JDMF, 1 KDMF, 1 NDC API, 14 Listed Suppliers, $ API Reference Price

35 API Suppliers
10 USDMF
7 CEP/COS
12 JDMF
1 KDMF
1 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

FINISHED DOSAGE FORMULATIONS

507 FDF Dossiers, 135 Europe, 11 Canada, 310 South Africa, 51 Listed Dossiers

507 FDF Dossiers
135 Europe
11 Canada
310 South Africa
51 Listed Dossiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 48 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
48 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

134 Finished Drug Prices

globalSalesInformation
134 Finished Drug Prices

MARKET PLACE

31 APIs, 10 FDF Dossiers, 14 EXCIPIENTS

marketPlace
31 APIs
10 FDF Dossiers
14 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 EDQM , 3 USP , 1 Others

otherSolutions
1 EDQM
3 USP
1 Others

ANALYTICAL

9 Analytical Methods

otherMethods
9 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

507

FDF Dossiers

FDA Orange Book

135

Europe

Canada

Australia

310

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: D-glc, D-glucopyranose, D-glucopyranoside, Glc, Glucopyranose, Glucopyranoside

Molecular Formula

C₆H₁₂O₆

Molecular Weight

180.16 g/mol

InChI Key

WQZGKKKJIJFFOK-GASJEMHNSA-N

D-Glucose is a metabolite found in or produced by Saccharomyces cerevisiae.

1 2D Structure

Glucose

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

2.1.2 InChI

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1

2.1.3 InChI Key

WQZGKKKJIJFFOK-GASJEMHNSA-N

2.1.4 Canonical SMILES

C(C1C(C(C(C(O1)O)O)O)O)O

2.1.5 Isomeric SMILES

C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. D-glc

2. D-glucopyranose

3. D-glucopyranoside

4. Glc

5. Glucopyranose

6. Glucopyranoside

7. Glucose

8. 2280-44-6

9. Grape Sugar

10. D-glcp

11. (3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

12. Traubenzucker

13. Glucose Solution

14. Dextrose Solution

15. Chebi:4167

16. Corn Sugar

17. Glucopyranose, D-

18. 54-17-1

19. (3r,4s,5s,6r)-6-(hydroxymethyl)tetrahydro-2h-pyran-2,3,4,5-tetraol

20. Dsstox_cid_2910

21. Rel-(3r,4s,5s,6r)-6-(hydroxymethyl)tetrahydro-2h-pyran-2,3,4,5-tetraol

22. Glucodin

23. Goldsugar

24. Meritose

25. Vadex

26. Clintose L

27. Cpc Hydrate

28. Roferose St

29. A-d-glucose

30. Clearsweet 95

31. A-d-glucopyranose

32. Staleydex 95m

33. Staleydex 111

34. (+)-glucose

35. Cerelose 2001

36. Tabfine 097(hs)

37. 2h-pyran-2,3,4,5-tetraol

38. D-glucopyranose, Anhydrous

39. Glc-ring

40. Cartose Cerelose

41. D-glucose-ring

42. Glucose Injection

43. Glucose 40

44. Staleydex 130

45. Einecs 218-914-5

46. Glc-oh

47. Meritose 200

48. Nchembio867-comp4

49. Dextrose, Unspecified

50. Glucose (jp17)

51. Starbld0000491

52. 6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetraol

53. Anhydrous Glucose ,(s)

54. Glucose, Unspecified Form

55. Dextrose, Unspecified Form

56. Purified Glucose (jp17)

57. Epitope Id:142342

58. D-(+)-dextrose

59. Dsstox_rid_76784

60. Dsstox_rid_82925

61. Dsstox_gsid_22910

62. Dsstox_gsid_48729

63. Gtpl4536

64. Chembl1222250

65. Bdbm34103

66. Dtxsid501015215

67. Dtxsid901015217

68. Tox21_113165

69. Tox21_200145

70. Akos025147374

71. Nsc 287045

72. Cas-50-99-7

73. Ncgc00166293-01

74. Ncgc00257699-01

75. Bs-48662

76. Cas-58367-01-4

77. G0048

78. (3r,4s,5s,6r)-6-(hydroxymethyl)tetrahydro-

79. C00031

80. D00009

81. F71542

82. Q37525

83. Q23905964

84. N_full/o_full_10000000000000_gs_656

85. D-glucose (closed Ring Structure, Complete Stereochemistry)

86. Wurcs=2.0/1,1,0/[a2122h-1x_1-5]/1/

2.3 Create Date

2005-06-08

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₂O₆
Molecular Weight	180.16 g/mol
XLogP3	-2.6
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	180.06338810 g/mol
Monoisotopic Mass	180.06338810 g/mol
Topological Polar Surface Area	110 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	151
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used in metabolic disorders such as hypoglycemia.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Blood glucose is an obligatory energy source in humans involved in various cellular activities, and it also acts as a signalling molecule for diverse glucose-sensing molecules and proteins. Glucose undergoes oxidation into carbon dioxide, water and yields energy molecules in the process of glycolysis and subsequent citric cycle and oxidative phosphorylation. Glucose is readily converted into fat in the body which can be used as a source of energy as required. Under a similar conversion into storage of energy, glucose is stored in the liver and muscles as glycogen. Glucose stores are mobilized in a regulated manner, depending on the tissues' metabolic demands. Oral glucose tablets or injections serve to increase the supply of glucose and oral glucose administration is more effective in stimulating insulin secretion because it stimulates the incretin hormones from the gut, which promotes insulin secretion.

5.2 ATC Code

B - Blood and blood forming organs

B05 - Blood substitutes and perfusion solutions

B05C - Irrigating solutions

B05CX - Other irrigating solutions

B05CX01 - Glucose

V - Various

V04 - Diagnostic agents

V04C - Other diagnostic agents

V04CA - Tests for diabetes

V04CA02 - Glucose

V - Various

V06 - General nutrients

V06D - Other nutrients

V06DC - Carbohydrates

V06DC01 - Glucose

5.3 Absorption, Distribution and Excretion

Absorption

Polysaccharides can be broken down into smaller units by pancreatic and intestinal glycosidases or intestinal flora. Sodium-dependent glucose transporter SGLT1 and GLUT2 (SLC2A2) play predominant roles in intestinal transport of glucose into the circulation. SGLT1 is located in the apical membrane of the intestinal wall while GLUT2 is located in the basolateral membrane, but it was proposed that GLUT2 can be recruited into the apical membrane after a high luminal glucose bolus allowing bulk absorption of glucose by facilitated diffusion. Oral preparation of glucose reaches the peak concentration within 40 minutes and the intravenous infusions display 100% bioavailability.

Route of Elimination

Glucose can be renally excreted.

Volume of Distribution

The mean volume of distribution after intravenous infusion is 10.6L.

Clearance

The mean metabolic clearance rate of glucose (MCR) for the 10 subjects studied at the higher insulin level was 2.27 0.37 ml/kg/min at euglycemia and fell to 1.510.21 ml/kg/ at hyperglycemia. The mean MCR for the six subjects studied at the lower insulin level was 1.91 0.31 ml/kg/min at euglyglycemia.

5.4 Metabolism/Metabolites

Glucose can undergo aerobic oxidation in conjunction to the synthesis of energy molecules. Glycolysis is the initial stage of glucose metabolism where one glucose molecule is degraded into 2 molecules of pyruvate via substrate-level phosphorylation. These products are transported to the mitochondria where they are further oxidized into oxygen and carbon dioxide.

5.5 Biological Half-Life

The approximate half-life is 14.3 minutes following intravenous infusion. Gut glucose half-life was markedly higher in females (79 2 min) than in males (65 3 min, P < 0.0001) and negatively related to body height (r = -0.481; P < 0.0001).

5.6 Mechanism of Action

Glucose supplies most of the energy to all tissues by generating energy molecules ATP and NADH during a series of metabolism reactions called glycolysis. Glycolysis can be divided into 2 main phases where the preparatory phase is initiated by the phosphorylation of glucose by a hexokinase to form glucose 6-phosphate. The addition of the high-energy phosphate group activates glucose for subsequent breakdown in later steps of glycolysis and is the rate-limiting step. Products end up as substrates for following reactions, to ultimately convert C6 glucose molecule into two C3 sugar molecules. These products enter the energy-releasing phase where total of 4ATP and 2NADH molecules are generated per one glucose molecule. The total aerobic metabolism of glucose can produce up to 36 ATP molecules. This energy-producing reactions of glucose is limited to D-glucose as L-glucose cannot be phosphorlyated by hexokinase. Glucose can act as precursors to generate other biomolecules such as vitamin C. It plays a role as a signaling molecule to control glucose and energy homeostasis. Glucose can regulate gene transcription, enzyme activity, hormone secretion, and the activity of glucoregulatory neurons. The types, number and kinetics of glucose transporters expressed depends on the tissues and fine-tunes glucose uptake, metabolism, and signal generation in order to preserve cellular and whole body metabolic integrity.

API SUPPLIERS

01

Evonik

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Adhesives & Bonding Expo

Attending

Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!

Contact Supplier

Germany

Virtual Booth

Digital Content

USDMF

Click Us!

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

02

Roquette

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

03

Shandong Tianli Pharmaceutical Co ...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

04

Ingredion Pharma Solutions

U.S.A

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

09

XIWANG PHARMACEUTICAL CO LTD

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

10

XIWANG PHARMACEUTICAL CO LTD

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

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API Reference Price

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