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Chemistry

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Also known as: Glycerin, 56-81-5, Glycerine, 1,2,3-propanetriol, Propane-1,2,3-triol, Glycyl alcohol
Molecular Formula
C3H8O3
Molecular Weight
92.09  g/mol
InChI Key
PEDCQBHIVMGVHV-UHFFFAOYSA-N
FDA UNII
PDC6A3C0OX

Glycerine
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
Glycerin is a Non-Standardized Chemical Allergen. The physiologic effect of glycerin is by means of Increased Histamine Release, and Cell-mediated Immunity, and Increased IgG Production.
1 2D Structure

Glycerine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
propane-1,2,3-triol
2.1.2 InChI
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
2.1.3 InChI Key
PEDCQBHIVMGVHV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(C(CO)O)O
2.2 Other Identifiers
2.2.1 UNII
PDC6A3C0OX
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,2,3-propanetriol

2. 1,2,3-trihydroxypropane

3. Glycerin

4. Glycerine

2.3.2 Depositor-Supplied Synonyms

1. Glycerin

2. 56-81-5

3. Glycerine

4. 1,2,3-propanetriol

5. Propane-1,2,3-triol

6. Glycyl Alcohol

7. Trihydroxypropane

8. Glyceritol

9. Propanetriol

10. 1,2,3-trihydroxypropane

11. Osmoglyn

12. Polyglycerine

13. Grocolene

14. Glysanin

15. Glyrol

16. Glycerin, Synthetic

17. Polyglycerol

18. Dagralax

19. Glycerinum

20. Ophthalgan

21. Vitrosupos

22. Glycerin, Anhydrous

23. Synthetic Glycerin

24. Synthetic Glycerine

25. Optim

26. Moon

27. Star

28. Incorporation Factor

29. Glycerolum

30. 90 Technical Glycerine

31. Glycerin Mist

32. Glycerin (mist)

33. 25618-55-7

34. Citifluor Af 2

35. Bulbold

36. Cristal

37. Glicerina [dcit]

38. Glycerine Mist

39. Caswell No. 469

40. Glycerin [jan]

41. Fema No. 2525

42. Propanetriol (van)

43. Glycerin Base

44. Tryhydroxypropane

45. Glycerin, Natural

46. Glycerin,anhydrous

47. Glicerol [inn-spanish]

48. Glycerolum [inn-latin]

49. Clyzerin, Wasserfrei

50. Pricerine 9091

51. Clyzerin, Wasserfrei [german]

52. Emery 916

53. Ccris 2295

54. Hsdb 492

55. Monoctanoin Component D

56. Epa Pesticide Chemical Code 063507

57. Collyrium Fresh-eye Drops

58. Ai3-00091

59. Nsc 9230

60. Glycerol [inn]

61. Brn 0635685

62. Ifp

63. Di-o-tolylphenylphosphine

64. Dynastin 7

65. Nsc-9230

66. Mfcd00004722

67. Pdc6a3c0ox

68. 1,2,3-trihydroxypropanol

69. Ins No.422

70. Chebi:17754

71. Ins-422

72. Nsc9230

73. Glycerol (inn)

74. M 314429

75. 101662-08-2

76. 144086-03-3

77. Pzn 7474853

78. Ncgc00090950-03

79. Diacylglycerol(35:0)

80. 2-propenoic Acid, Polymer With Oxirane And 1,2,3-propanetriol

81. Dsstox_cid_662

82. E-422

83. Dsstox_rid_75717

84. Dsstox_gsid_20663

85. 107283-02-3

86. 153050-05-6

87. 18803-09-3

88. 1h-thieno[3,4-d]imidazole-4-pentanamide, Hexahydro-2-oxo-n-[6-oxo-6-(2-propenylamino)hexyl]-, (3as,4

89. 2-propenoic Acid, Polymer With 2,2-bis(hydroxymethyl)-1,3-propanediol, Methyloxirane And Oxirane

90. 26403-55-4

91. Glycerol; Propane-1,2,3-triol

92. Glicerina

93. Glicerol

94. Heterochromatin-specific Nonhistone Chromosomal Protein Hp-1

95. Dag 31:3

96. Dag 35:0

97. Dag(35:0)

98. Glycerol, Acs Reagent, >=99.5%

99. Poly[oxy(2-hydroxy-1,3-propanediyl)], Alpha-hydro-omega-hydroxy-

100. Glyceol Opthalgan

101. Dg 31:3

102. Dg 35:0

103. Cas-56-81-5

104. Dg(31:3)

105. Dg(35:0)

106. Gol

107. Mackstat H 66

108. Wurcs=2.0/1,1,0/[h2h]/1/

109. Glycerin [usp:jan]

110. Rg-s

111. Einecs 200-289-5

112. Unii-pdc6a3c0ox

113. Neutracett

114. Glyceol

115. Glyzerin

116. Oelsuess

117. Glycerine Usp

118. Artifical Tears

119. D-glycerol

120. L-glycerol

121. Organic Glycerin

122. Glycerol Solution

123. Organic Glycerine

124. Glycerine (crude)

125. Polyhydric Alcohols

126. 1,3-propanetriol

127. Glycerol, Ultrapure

128. Glycerin Usp Grade

129. Glycerine 96%

130. Glycerol 85%

131. Diacylglycerol 31:3

132. Diacylglycerol 35:0

133. 8043-29-6

134. Glycerin 99.5%

135. Glycerine 96% Usp

136. 1,3-trihydroxypropane

137. 90 Technical Glycerin

138. Emery 912

139. Diacylglycerol(31:3)

140. Glycerin [hsdb]

141. Glycerin [inci]

142. Glycerol [fhfi]

143. Glycerin [ii]

144. Glycerol [mi]

145. Glycerin [vandf]

146. Dl-[1-13c]glycerol

147. Glycerinum [hpus]

148. E 422

149. Glycerin (jp17/usp)

150. Glycerin 99.5% Usp

151. Glycerine 99.7% Usp

152. Glycerol [mart.]

153. Bmse000184

154. Bmse000807

155. Bmse000856

156. Chembl692

157. Glycerin [usp-rs]

158. Glycerol [who-dd]

159. Glycerol [who-ip]

160. Molmap_000024

161. Ec 200-289-5

162. Glycerol, >=99.5%

163. Glycerol, Biochemical Grade

164. Glycerin Reagent Grade Acs

165. Wln: Q1yq1q

166. Glycerine (fragrance Grade)

167. 2-hydroxylpropane-1,3-diol

168. Glycerol, Lr, >=98%

169. Glycerol, Analytical Standard

170. 4-01-00-02751 (beilstein Handbook Reference)

171. Glycerol, Cell Culture Grade

172. Glycerol-[1,3-13c2]

173. Glycerin, Concentrated (jan)

174. Glycerol Min 98%, Anhydrous

175. Concentrated Glycerin (jp17)

176. Glycerol 3 M Solution, 3 M

177. Glycerol, >=99% (gc)

178. Glycerin [orange Book]

179. Glycerol [ep Impurity]

180. Gtpl5195

181. Qspl 181

182. Glycerol [ep Monograph]

183. Dtxsid9020663

184. Glycerin [usp Monograph]

185. Glycerol, Ar, >=99.5%

186. Pentrioxido Sulfurico Glycerincol

187. Glycerol, >99%, Fcc, Fg

188. Glycerol, Technical Grade, 95%

189. Glycerol, Ultrapure, Hplc Grade

190. 2w97

191. Chebi:131416

192. Chebi:178017

193. Chebi:189439

194. Glycerol 85% [who-dd]

195. Glycerol, Acs Reagent, 99.5%

196. Glycerol, Molecular Biology Grade

197. Glycerolum [who-ip Latin]

198. Glycerin,anhydrous [vandf]

199. Pharmakon1600-01300020

200. Zinc895048

201. Glycerol, Vetec(tm) Reagent Grade

202. Glycerol Solution, 86-89% (t)

203. Hy-b1659

204. Str02073

205. Glycerine 912 (96% Cp/usp)

206. Tox21_111043

207. Tox21_202077

208. Tox21_300144

209. C0066

210. Dag(31:3)

211. Glycerol, Bioxtra, >=99% (gc)

212. Glycerol, Reagentplus(r), >=99%

213. Nsc759633

214. S2766

215. Stl199174

216. 2-propanol, 1,3-dihydroxy-

217. Akos000120102

218. Cs-6964

219. Db09462

220. Glycerol, Usp, 99.0-101.0%

221. Nsc-759633

222. Sb83762

223. Glycerin; Propane-1,2,3-triol

224. Glycerolglycerin; Propane-1,2,3-triol

225. Glycerol, Saj First Grade, >=98.0%

226. Ncgc00090950-01

227. Ncgc00090950-02

228. Ncgc00090950-04

229. Ncgc00090950-05

230. Ncgc00253975-01

231. Ncgc00259626-01

232. Bp-31039

233. E422

234. Glycerol, For Molecular Biology, >=99%

235. Glycerol, Jis Special Grade, >=99.0%

236. Glycerol, Vetec(tm) Reagent Grade, 99%

237. Glycerin, Meets Usp Testing Specifications

238. Ft-0626742

239. Ft-0669018

240. Ft-0697060

241. G0316

242. Glycerol, Ultrapure, Spectrophotometric Grade

243. Glycerol, Reagentplus(r), >=99.0% (gc)

244. Glycerol, Spectrophotometric Grade, >=99.5%

245. C00116

246. D00028

247. D92249

248. A831186

249. Glycerol Solution, Puriss. P.a., 86-89% (t)

250. Glycerol, Tested According To Ph.eur., Anhydrous

251. Q132501

252. Brd-k73866522-001-02-6

253. Glycerol-gelatine, For Mounting (histochemical Slides)

254. F0001-1470

255. 8dfdfcd7-1ed2-4373-845e-054f5ad00089

256. Glycerin, United States Pharmacopeia (usp) Reference Standard

257. Glycerin, Pharmaceutical Secondary Standard; Certified Reference Material

258. Glycerol, Bioultra, For Molecular Biology, Anhydrous, >=99.5% (gc)

259. Glycerol, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 98.0-101.0%

260. Glycerol, Puriss. P.a., Acs Reagent, Anhydrous, Dist., >=99.5% (gc)

261. Astm(r) D6584 Glycerin Solution, 500 Mug/ml In Pyridine, Analytical Standard

262. Astm(r) D6584 Glycerin Solution, Certified Reference Material, 500 Mug/ml In Pyridine

263. Glycerol Solution, Puriss., Meets Analytical Specification Of Ph.??eur., Bp, 84-88%

264. Glycerol, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Electrophoresis, >=99% (gc)

265. Glycerol, Polymer-bound, Extent Of Labeling: 1-2 Mmol/g Glycerol Loading, 1 % Cross-linked With Divinylbenzene

266. Glycerol, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, Fcc, E422, Anhydrous, 99.0-101.0% (alkalimetric)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 92.09 g/mol
Molecular Formula C3H8O3
XLogP3-1.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass92.047344113 g/mol
Monoisotopic Mass92.047344113 g/mol
Topological Polar Surface Area60.7 Ų
Heavy Atom Count6
Formal Charge0
Complexity25.2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Cathartics; Cryoprotective Agents; Solvents; Vehicles

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


/Glycerin is indicated/ for relief of occasional constipation.

US Natl Inst Health; DailyMed. Current Medication Information for ADULT GLYCERIN LAXATIVE (glycerin) suppository (February 2010). Available from, as of July 18, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f44d5cca-c28d-4f37-92db-510f6605be90


/Glycerin/ is indicated as a/ lubricant /to/ relieve dryness of the eyes and prevent further irritation.

US Natl Inst Health; DailyMed. Current Medication Information for SOOTHE (glycerin and propylene glycol) solution/ drops (August 2010). Available from, as of July 18, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fef002ea-c4bd-4486-a42e-1bbd9d73d28d


Glycerin ophthalmic solution may be used topically to reduce superficial corneal edema resulting from disease to facilitate opthalmoscopic and gonioscopic examination.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 93. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1993 (Plus Supplements, 1993)., p. 1773


For more Therapeutic Uses (Complete) data for GLYCERIN (7 total), please visit the HSDB record page.


4.2 Drug Warning

For rectal use only. May cause rectal discomfort or a burning sensation.

US Natl Inst Health; DailyMed. Current Medication Information for ADULT GLYCERIN LAXATIVE (glycerin) suppository (February 2010). Available from, as of July 18, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f44d5cca-c28d-4f37-92db-510f6605be90


Do not use for more than one per day; for a period of longer than one week unless directed by a doctor; laxative products when abdominal pain, nausea, or vomiting are present unless directed by a doctor; if seal under product lid is damaged, missing or broken.

US Natl Inst Health; DailyMed. Current Medication Information for ADULT GLYCERIN LAXATIVE (glycerin) suppository (February 2010). Available from, as of July 18, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f44d5cca-c28d-4f37-92db-510f6605be90


If you have rectal bleeding or fail to have a bowel movement after using a laxative. This may indicate a serious condition.

US Natl Inst Health; DailyMed. Current Medication Information for ADULT GLYCERIN LAXATIVE (glycerin) suppository (February 2010). Available from, as of July 18, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f44d5cca-c28d-4f37-92db-510f6605be90


Adverse effects occur rarely following rectal administration of glycerin or sorbitol. Glycerin may produce rectal discomfort, irritation, burning or griping, cramping pain and tenesmus. Hyperemia of the rectal mucosa with minimal amounts of hemorrhage and mucus discharge may also occur. These adverse effects occur less frequently following rectal administration of sorbitol.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011


For more Drug Warnings (Complete) data for GLYCERIN (11 total), please visit the HSDB record page.


4.3 Drug Indication

It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.


5.2 MeSH Pharmacological Classification

Cryoprotective Agents

Substances that provide protection against the harmful effects of freezing temperatures. (See all compounds classified as Cryoprotective Agents.)


Solvents

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh's Chemical Dictionary, 5th ed) (See all compounds classified as Solvents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
GLYCERIN
5.3.2 FDA UNII
PDC6A3C0OX
5.3.3 Pharmacological Classes
Cell-mediated Immunity [PE]; Glycerol [CS]; Increased Histamine Release [PE]; Increased IgG Production [PE]; Non-Standardized Chemical Allergen [EPC]; Allergens [CS]
5.4 ATC Code

A - Alimentary tract and metabolism

A06 - Drugs for constipation

A06A - Drugs for constipation

A06AG - Enemas

A06AG04 - Glycerol


A - Alimentary tract and metabolism

A06 - Drugs for constipation

A06A - Drugs for constipation

A06AX - Other drugs for constipation

A06AX01 - Glycerol


5.5 Absorption, Distribution and Excretion

Absorption

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach


Route of Elimination

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.


Volume of Distribution

Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.


Data from studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach, distributed over the extracellular space and excreted.

United Nations Environment Programme: Screening Information Data Sheets on Glycerol (56-81-5) (March 2002) Available from, as of July 14, 2009: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html


After hydrolysis of glycerol esters in the intestine, glycerol is readily absorbed.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 48: Aliphatic acyclic diols, triols, and related substances (56-81-5) (2002). Available from, as of July 14, 2011: https://www.inchem.org/pages/jecfa.html


Following rectal administration, glycerin and sorbitol are poorly absorbed; colonic evacuation of glycerin rectal suppositories or enemas occurs within 15-60 minutes, while colonic evacuation of oral sorbitol occurs within 24-48 hours.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011


Following absorbption from GI tract, glycerin is distributed throughout the blood. Although glycerin glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 93. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1993 (Plus Supplements, 1993)., p. 1773


For more Absorption, Distribution and Excretion (Complete) data for GLYCERIN (7 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Glycerin is a substrate for synthesis of triacylglycerols and of phospholipids in the liver and adipose tissue. When fat metabolized as a source of energy, glycerol and fatty acids are released into the bloodstream. Circulating glycerin does not glycate proteins and does not lead to the formation of advanced glycation endproducts (AGEs). In some organisms, the glycerin component can enter the glycolysis pathway directly to provide a substrate for energy or glucose production. Glycerol must be converted to their intermediate glyceraldehyde 3-phosphate before being used in glycolysis or gluconeogenesis. Glycerol metabolism is regulated by the enzymes glycerol kinase, (cytosolic) NAD+-dependent G3P dehydrogenase and (mitochondrial) FAD-linked G3P dehydrogenase.


Glycerol is phosphorylated to alpha-glycerophosphate by glycerol kinase predominantly in the liver (80-90%) and kidneys (10-20%) and incorporated in the standard metabolic pathways to form glucose and glycogen. Glycerol kinase is also found in intestinal mucosa, brown adipose tissue, lymphatic tissue, lung and pancreas. Glycerol may also be combined with free fatty acids in the liver to form triglycerides (lipogenesis) which are distributed to the adipose tissues. The turnover rate is directly proportional to plasma glycerol levels.

United Nations Environment Programme: Screening Information Data Sheets on Glycerol (56-81-5) (March 2002) Available from, as of July 14, 2009: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html


Glycerol is endogenous in the human body. It enters the glycolytic pathway after its conversion in the liver to glycerol-3-phosphate by glycerol kinase. Glycerol-3-phosphate is then oxidized by glycerol-3-phosphate dehydrogenase to yield dihydroxyacetone phosphate, which is then isomerized to glyceral-dehyde-3-phosphate, eventually yielding pyruvic acid.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 48: Aliphatic acyclic diols, triols, and related substances (56-81-5) (2002). Available from, as of July 14, 2011: https://www.inchem.org/pages/jecfa.html


Glycerol esters are hydrolyzed to glycerol and the corresponding carboxylic acids. The hydrolysis is catalysed by intestinal lipase, which attacks the ester bonds at carbons 1 and 3. The ester bond at carbon 2 is more resistant to hydrolysis, possibly because of its stereochemistry and steric hindrance. The beta-monoglyceride can, however, spontaneously isomerise to the alpha-form (3-acylglycerol), permitting further hydrolysis to yield glycerol.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 48: Aliphatic acyclic diols, triols, and related substances (56-81-5) (2002). Available from, as of July 14, 2011: https://www.inchem.org/pages/jecfa.html


Glycerol, pyruvic acid, and lactic acid are endogenous in humans. Glycerol and pyruvic acid are metabolized completely and are not excreted. ... Glycerol is metabolized via the glycolytic pathway after it has been converted in the liver to glycerol-3-phosphate.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 48: Aliphatic acyclic diols, triols, and related substances (56-81-5) (2002). Available from, as of July 14, 2011: https://www.inchem.org/pages/jecfa.html


For more Metabolism/Metabolites (Complete) data for GLYCERIN (6 total), please visit the HSDB record page.


5.7 Biological Half-Life

30 - 45 minutes


Elimination half-life of glycerin is about 30-40 min.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 93. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1993 (Plus Supplements, 1993)., p. 1773


5.8 Mechanism of Action

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.


Glycerin (glycerol) and sorbitol are hyperosmotic laxatives.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011


When administered rectally, glycerin and sorbitol exert a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexly stimulating evacuation. The extent to which the simple physical distention of the rectum and the hygroscopic and/or local irritant actions are responsible for the laxative effects of some of these drugs is not known. Only extremely high oral doses of sorbitol (25 g daily) or glycerin exert laxative action.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011


/Glycerin/ decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

Physicians Desk Reference for Ophthalmic Medicines 38th ed. Thomson Reuters. Montvale, NJ 2010.


The physicochemical effects of a series of alkanols, alkanediols and glycerol on erythrocyte shape and hemolysis at 4 and 20 degrees C were examined. We calculated the dielectric constant of the incubation medium, Ds, and the dielectric constant of the erythrocyte membrane Dm in the presence of organic solutes. The ratio Ds/Dm = -38.48 at 20 degrees C defines the normal biconcave shape in a medium without hemolytic agents. A decrease in Ds/Dm favors externalization or internalization with consequent hemolysis. Alkanols and alkanediols convert biconcave erythrocytes into echinocytes, which is accompanied by an increase in the projected surface area. Glycerol converts biconcave erythrocytes into stomatocytes, which was accompanied by a marginal decrease in the projected surface area. Progressive externalization in alkanols and alkanediols or internalization in glycerol resulted in a decrease in the projected surface area and the formation of smooth spheres. The degree of shape change induced was related to the degree of hemolysis and the ratio Ds/Dm. A decrease in temperature reduced both the degree of shape change and hemolysis. .../Thus/ physicochemical toxicity may be a result of a temperature dependent hydrophobic interaction between the organic solutes and the membrane and is best interpreted by the ability of the solutes to change Ds and Dm.

PMID:8634318 Bakaltcheva IB et al; Biochim Biophys Acta 1280 (1): 73-80 (1996)


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Avanti Polar Lipids, Inc.

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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03

Avanti Polar Lipids, Inc.

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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Avanti Polar Lipids, Inc.

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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04

Lonza Group

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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Lonza Group

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
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05

STEPAN SPECIALTY PRODUCTS LLC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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STEPAN SPECIALTY PRODUCTS LLC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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06

Mohini Organics Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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Mohini Organics Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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07

Estelle Chemicals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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Estelle Chemicals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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08

ReAgent Chemicals

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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ReAgent Chemicals

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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09

Sakai Chemical Industries

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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Sakai Chemical Industries

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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World Vaccine Congress
Not Confirmed
USDMF CEP/COS JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
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10

Hoventa Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

World Vaccine Congress
Not Confirmed
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API Reference Price

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IT 16147 GENOVA","supplierCountry":"ITALY","foreign_port":"GENOA","customer":"LASENOR INDIA PRIVATE ","customerCountry":"INDIA","quantity":"15000.00","actualQuantity":"15000","unit":"KGS","unitRateFc":"2.9","totalValueFC":"49202.2","currency":"EUR","unitRateINR":"274.9","date":"19-Sep-2024","totalValueINR":"4123205.32","totalValueInUsd":"49202.2","indian_port":"CONCOR ICD MIHAN","hs_no":"29054900","bill_no":"5676167","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"GENOA","supplierAddress":"VIA PROF. SILVIO ROLANDO, 22 CARASCO GE 16042 ITALY IT","customerAddress":"502, ABHAY STEEL HOUSE, BARODA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"GLYCEROL ANHYDROUS (VEGETABLE) EMPROVE EXPERT PH EUR,BP,CHP,JP,USP,ACS 5PCS X 25L (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"157.50","actualQuantity":"157.5","unit":"KGS","unitRateFc":"1904.3","totalValueFC":"3588","currency":"INR","unitRateINR":"1909.1","date":"21-Sep-2024","totalValueINR":"300679.83","totalValueInUsd":"3588","indian_port":"Bombay Air","hs_no":"29054500","bill_no":"5720951","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darm stadt,(BENEFICIARY MERCKFINANCIALS SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"GLYCEROL ANHYDROUS (VEGETABLE) EMPROVE EXPERT PH EUR,BP,CHP,JP,USP,ACS 76PCS X 1KG (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"76.00","actualQuantity":"76","unit":"KGS","unitRateFc":"5012.3","totalValueFC":"4557","currency":"INR","unitRateINR":"5024.8","date":"21-Sep-2024","totalValueINR":"381884.85","totalValueInUsd":"4557","indian_port":"Bombay Air","hs_no":"29054500","bill_no":"5732964","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darm stadt,(BENEFICIARY MERCKFINANCIALS SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727029800,"product":"REFINED GLYCERINE 99.7","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"NATURAL OLEOCHEMICALS SDN ","supplierCountry":"MALAYSIA","foreign_port":"PASIR GUDANG","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"12500.00","actualQuantity":"12500","unit":"KGS","unitRateFc":"1.6","totalValueFC":"19938.3","currency":"USD","unitRateINR":"133.7","date":"23-Sep-2024","totalValueINR":"1670850","totalValueInUsd":"19938.3","indian_port":"JNPT","hs_no":"29054500","bill_no":"5751109","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PASIR GUDANG","supplierAddress":"PLO 428, JALAN BESI SATU KAWASAN PERINDUSTRIAN PASIR GUDANG JOHOR SDNF MY","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"GLYCEROL ANHYDROUS (VEGETABLE) EMPROVE EXPERT PH EUR,BP,CHP,JP,USP,ACS 5PCS X 25L (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"157.50","actualQuantity":"157.5","unit":"KGS","unitRateFc":"1904.3","totalValueFC":"3588","currency":"INR","unitRateINR":"1909.1","date":"26-Sep-2024","totalValueINR":"300679.83","totalValueInUsd":"3588","indian_port":"Bombay Air","hs_no":"29054500","bill_no":"5807724","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darm stadt,(BENEFICIARY MERCKFINANCIALS SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"GLYCEROL ANHYDROUS (VEGETABLE) EMPROVE EXPERT PH EUR,BP,JP,USP,ACS 30PCS X 25L (NOT FOR FOOD PRODUCT)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"945.00","actualQuantity":"945","unit":"KGS","unitRateFc":"1731.2","totalValueFC":"19571","currency":"INR","unitRateINR":"1735.5","date":"26-Sep-2024","totalValueINR":"1640071.55","totalValueInUsd":"19571","indian_port":"JNPT","hs_no":"29054500","bill_no":"5811187","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"Frankfurter Strasse 250, 64293 Darm stadt,(BENEFICIARY MERCKFINANCIALS SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"GLYCERINE 4810 (GLYCEROL PH. EUR)","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"OLEON ASIA PACIFIC ","supplierCountry":"FRANCE","foreign_port":"ANTWERPEN","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20000.00","actualQuantity":"20000","unit":"KGS","unitRateFc":"1.8","totalValueFC":"36747","currency":"USD","unitRateINR":"154","date":"26-Sep-2024","totalValueINR":"3079440","totalValueInUsd":"36747","indian_port":"JNPT","hs_no":"29054500","bill_no":"5817598","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"ANTWERPEN","supplierAddress":"SUITE 28-08, LEVEL 28, CENTRO 8 JALAN BATU TIGA LAMA KLANG, SELANGOR MY","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"REFINED GLYCERINE 99.7 PCNT MIN (NOT FOR MEDICINAL USE, FORINDUSTRIAL USE ONLY) (AIFTA NO.0065586\/JKP\/2024 DT.12.09.24)","address":"RAMA-GULAB APARTMENT, (BACK SIDE)","city":"MUMBAI, MAHARASHTRA.","supplier":"PT SINARMAS BIO ENERGY","supplierCountry":"INDONESIA","foreign_port":"JAKARTA","customer":"AMBER CHEMICALS","customerCountry":"INDIA","quantity":"100000.00","actualQuantity":"100000","unit":"KGS","unitRateFc":"0.7","totalValueFC":"65619.6","currency":"USD","unitRateINR":"55","date":"27-Sep-2024","totalValueINR":"5499000","totalValueInUsd":"65619.6","indian_port":"Mundra","hs_no":"29054500","bill_no":"5821223","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Non Pharma","supplierPort":"JAKARTA","supplierAddress":"GEDUNG SINAR MAS LAND PLAZA MENARA II LT. 20,JL. MH. THAMRIN NO.51 RT. 008 RW.005, GONDANGDIA, MENTENGJAKA INDONESIA","customerAddress":"RAMA-GULAB APARTMENT, (BACK SIDE)"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"REFINED GLYCERINE 99.7% MIN USP GRADE(NOT FOR FOOD OR MEDICINAL USE)(INV NO. IU2501\/T057\/8\/2024)","address":"5, J.B.S. HALDEN AVENUE,1ST FLOOR,","city":"KOLKATA,WEST BENGAL","supplier":"INTER-UNITED ENTERPRISES PTE LTD.","supplierCountry":"INDONESIA","foreign_port":"PANJANG","customer":"TRADEASIA INTERNATIONAL PRIVATE ","customerCountry":"INDIA","quantity":"120000.00","actualQuantity":"120","unit":"MTS","unitRateFc":"600.3","totalValueFC":"72728.4","currency":"USD","unitRateINR":"50789.4","date":"28-Sep-2024","totalValueINR":"6094731.2","totalValueInUsd":"72728.4","indian_port":"JNPT","hs_no":"29054500","bill_no":"5851164","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PANJANG","supplierAddress":"8 TEMASEK BOULEVARD #35-03 SUNTEC TOWER THREE 038988 SDNF SINGAPORE","customerAddress":"5, J.B.S. HALDEN AVENUE,1ST FLOOR,"}]
05-Jan-2021
30-Sep-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Europe

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01

SupplySide West 2024
Not Confirmed
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SupplySide West 2024
Not Confirmed

Glycerol; Sodium Chloride

Brand Name : Glycerol 10% Sodium Chloride 0.9%

Dosage Form :

Dosage Strength : 1 Bottle 250 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

SupplySide West 2024
Not Confirmed
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SupplySide West 2024
Not Confirmed

Glycerol

Brand Name :

Dosage Form : Suppository

Dosage Strength : 1G

Packaging : Strip- 12 Units

Approval Date :

Application Number :

Regulatory Info : EU CTD Dossier- Ready

Registration Country : Portugal

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03

SupplySide West 2024
Not Confirmed
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SupplySide West 2024
Not Confirmed

Glycerol

Brand Name :

Dosage Form : Suppository

Dosage Strength : 2G

Packaging : Strip- 12 Units

Approval Date :

Application Number :

Regulatory Info : EU CTD Dossier- Ready

Registration Country : Portugal

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04

SupplySide West 2024
Not Confirmed
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SupplySide West 2024
Not Confirmed

Glycerolum; Vaselinum album; Paraffinum liquidum

Brand Name : Dexeryl

Dosage Form : Creme

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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05

SupplySide West 2024
Not Confirmed
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SupplySide West 2024
Not Confirmed

Glycerolum; Vaselinum album; Paraffinum liquidum

Brand Name : Dexeryl

Dosage Form : Creme

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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06

ACO Hud Nordic AB

Country
SupplySide West 2024
Not Confirmed
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ACO Hud Nordic AB

Country
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SupplySide West 2024
Not Confirmed

glycerol

Brand Name : Glycerol ACO

Dosage Form : CREAM

Dosage Strength : 200 MG / G

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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07

ACO Hud Nordic AB

Country
SupplySide West 2024
Not Confirmed
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ACO Hud Nordic AB

Country
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SupplySide West 2024
Not Confirmed

glycerol

Brand Name : Miniderm

Dosage Form : KUTAN EMULSION

Dosage Strength : 20%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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08

EUROSPITAL SpA

Country
SupplySide West 2024
Not Confirmed
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EUROSPITAL SpA

Country
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SupplySide West 2024
Not Confirmed

Glycerol; Sodium Chloride

Brand Name : Glycerol 10% Sodium Chloride 0.9%

Dosage Form :

Dosage Strength : 1 500 Ml Bottle  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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09

MONICO SpA

Country
SupplySide West 2024
Not Confirmed
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MONICO SpA

Country
arrow
SupplySide West 2024
Not Confirmed

Glycerol; Sodium Chloride

Brand Name : Glycerol 10% Sodium Chloride 0.9%

Dosage Form :

Dosage Strength : 1 500 Ml Bottle  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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10

SALF SpA

Country
SupplySide West 2024
Not Confirmed
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SALF SpA

Country
arrow
SupplySide West 2024
Not Confirmed

Glycerol; Sodium Chloride

Brand Name : Glycerol 10% Sodium Chloride 0.9%

Dosage Form :

Dosage Strength : 1 500 Ml Bottle  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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