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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 26780-50-7, Poly(d,l-lactide-co-glycolide), Polyglactin, Poly(dl-lactide-co-glycolide), 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione, Vicryl (tn)

Molecular Formula

C₁₀H₁₂O₈

Molecular Weight

260.20 g/mol

InChI Key

LCSKNASZPVZHEG-UHFFFAOYSA-N

A polyester used for absorbable sutures and surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.

1 2D Structure

Glycolide - lactide copolymer

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione

2.1.2 InChI

InChI=1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

2.1.3 InChI Key

LCSKNASZPVZHEG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1C(=O)OC(C(=O)O1)C.C1C(=O)OCC(=O)O1

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Acid Polyester, Glycolic-lactic

2. Dimethyldioxanedione Polymer With Dioxanedione Polymer

3. Dioxanedione Polymer With Dimethyldioxanedione Polymer

4. Glycolic Lactic Acid Polyester

5. Glycolic-lactic Acid Polyester

6. Poly(glycolide Lactide)copolymer

7. Poly(lactide-co-glycolide)

8. Poly(lactide-co-glycoside)

9. Polyester, Glycolic-lactic Acid

10. Polygalactin 910

11. Polyglactin

12. Polyglactin 910

2.2.2 Depositor-Supplied Synonyms

1. 26780-50-7

2. Poly(d,l-lactide-co-glycolide)

3. Polyglactin

4. Poly(dl-lactide-co-glycolide)

5. 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione

6. Vicryl (tn)

7. Plga Lactide Glycolide

8. Polyglactin 370 (usan)

9. Polyglactin 910 (usan)

10. Schembl631659

11. Plga Lactide Glycolide 75:25

12. Dtxsid80910517

13. Poly (d,l-lactide-co-glycolide)

14. D05556

15. D06487

16. 1,4-dioxane-2,5-dione--3,6-dimethyl-1,4-dioxane-2,5-dione (1/1)

17. 107760-14-5

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₂O₈
Molecular Weight	260.20 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	0
Exact Mass	260.05321734 g/mol
Monoisotopic Mass	260.05321734 g/mol
Topological Polar Surface Area	105 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	267
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2