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1. Cystorelin
2. Dirigestran
3. Factrel
4. Fsh Releasing Hormone
5. Fsh-releasing Hormone
6. Gn-rh
7. Gnrh
8. Gonadoliberin
9. Gonadorelin
10. Gonadorelin Acetate
11. Gonadorelin Hydrochloride
12. Gonadotropin Releasing Hormone
13. Gonadotropin-releasing Hormone
14. Kryptocur
15. Lfrh
16. Lh Fsh Releasing Hormone
17. Lh Releasing Hormone
18. Lh-fsh Releasing Hormone
19. Lh-releasing Hormone
20. Lh-rh
21. Lhfsh Releasing Hormone
22. Lhfshrh
23. Lhrh
24. Luliberin
25. Luteinizing Hormone Releasing Hormone
26. Luteinizing Hormone-releasing Hormone
27. Releasing Hormone, Lhfsh
1. Lhrh
2. Lh-rh
3. Gonadoliberin, Luliberin
4. Gnrh
5. 9034-40-6
6. 71447-49-9
7. Lhrh, Human
8. Ncgc00182043-01
9. 6918-09-8
10. Chembl1981292
11. Luteinizing Hormone Releasingfactor
12. Bcp12609
13. Bcp12654
14. Luteinizing Hormone Releasing Factor
15. Syntheticgonadotropin-releasinghormone
16. Db00644
17. Ncgc00389662-01
18. Luteinizing Hormone Releasing Hormone Human
19. Db-057197
20. Ft-0628048
21. C07607
22. A821811
23. L000690
24. Luteinizing Hormone Releasing Hormone Human Acetate Salt;lhrh
25. Lhrh;lh-releasing Factor;gonadorelina;glp-his-trp-ser-tyr-gly-leu-ser-pro-gly-nh2
26. N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-azanyl-2-oxidanylidene-ethyl)carbamoyl]pyrrolidin-1-yl]-5-[bis(azanyl)methylideneamino]-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]amino]-3-(4-hydroxyphenyl)-1-o
27. N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropa
Molecular Weight | 1182.3 g/mol |
---|---|
Molecular Formula | C55H75N17O13 |
XLogP3 | -2.4 |
Hydrogen Bond Donor Count | 16 |
Hydrogen Bond Acceptor Count | 15 |
Rotatable Bond Count | 31 |
Exact Mass | 1181.57302551 g/mol |
Monoisotopic Mass | 1181.57302551 g/mol |
Topological Polar Surface Area | 475 Ų |
Heavy Atom Count | 85 |
Formal Charge | 0 |
Complexity | 2390 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 8 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Absorption
Rapidly absorbed when injected
Rapidly hydrolyzed to inactive peptide components
Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes
Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 2126
Submission : 1973-07-11
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 3368
Submission : 1978-09-11
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 9520
Submission : 1992-01-23
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 31909
Submission : 2017-07-07
Status : Active
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 4345
Submission : 1981-10-27
Status : Inactive
Type : II
USDMF
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 4410
Submission : 1982-01-07
Status : Inactive
Type : II
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GONADORELIN DIACETATE TETRAHYDRATE
NDC Package Code : 60870-0436
Start Marketing Date : 1999-01-21
End Marketing Date : 2024-12-31
Dosage Form (Strength) : POWDER (1g/g)
Marketing Category : BULK INGREDIENT
NDC Package Code : 67657-0005
Start Marketing Date : 1974-01-15
End Marketing Date : 2025-12-31
Dosage Form (Strength) : POWDER (1g/g)
Marketing Category : BULK INGREDIENT
API Imports and Exports
Importing Country | Total Quantity (KGS) |
Average Price (USD/KGS) |
Number of Transactions |
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RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 10,000 UNITS/VIAL
Approval Date :
Application Number : 17016
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 2,000 UNITS/VIAL
Approval Date :
Application Number : 17016
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 15,000 UNITS/VIAL
Approval Date :
Application Number : 17016
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 2,000 UNITS/VIAL
Approval Date :
Application Number : 17016
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : A.P.L.
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 20,000 UNITS/VIAL
Approval Date :
Application Number : 17055
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 5,000 UNITS/VIAL
Approval Date :
Application Number : 17067
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 10,000 UNITS/VIAL
Approval Date :
Application Number : 17067
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : INJECTABLE;INJECTION
Dosage Strength : 20,000 UNITS/VIAL
Approval Date :
Application Number : 17067
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : Injectable; Injection
Dosage Strength : 10,000 UNITS/VIAL
Approval Date :
Application Number : 89314
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CHORIONIC GONADOTROPIN
Dosage Form : Injectable; Injection
Dosage Strength : 10,000 UNITS/VIAL
Approval Date :
Application Number : 89315
RX/OTC/DISCN :
RLD :
TE Code :
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Regulatory Info :
Registration Country : Italy
Brand Name : Kryptocur
Dosage Form : Gonadorelin 0,2Mg/Dispensing Erog 100 2 Units Nasal Use
Dosage Strength : 2 bottles nasal spray 10 g
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : Hp Gonasi
Dosage Form :
Dosage Strength : 3 Ampoules Im Sc 250 U.I./1 Ml + 3 Solvent Ampoules 1 Ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Italy
Brand Name : Lutrelef
Dosage Form :
Dosage Strength : 1 Ampoule Ev Sc 0.8 Mg + 1 Ampoule Solv 10 Ml + 1 Syringe
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info :
Registration Country : Norway
Brand Name : REKOVELLE
Dosage Form : Injection fluid, resolution
Dosage Strength : 36 mcg
Packaging : Sylinderampulle
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Norway
Brand Name : REKOVELLE
Dosage Form : Injection fluid, resolution
Dosage Strength : 72 mcg
Packaging : Sylinderampulle
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Switzerland
Brand Name : Choriomon
Dosage Form : Dry Sub
Dosage Strength : 1000iu
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Switzerland
Brand Name : Choriomon
Dosage Form : Dry Sub
Dosage Strength : 2000iu
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Norway
Brand Name : Ovitrelle
Dosage Form : Injection fluid, resolution
Dosage Strength : 250 mcg/0.5 ml
Packaging : Finish filled syringe
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Norway
Brand Name : Ovitrelle
Dosage Form : Injection fluid, resolution
Dosage Strength : 250 mcg/0.5 ml
Packaging : Finish filled pen
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Italy
Brand Name : Pregnyl
Dosage Form : Chorionic Gonadotropin 5.000Iu 1 Unit Parenteral Use
Dosage Strength : 1 vial IM 5,000 IU + 1 ampoule solv 1 ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
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REF. STANDARDS & IMPURITIES
Gonadorelin
CAS Number : 34973-08-5
Quantity Per Vial : 5 mg
Sale Unit : 1
Order Code : G0525000
Batch No : 5
Price (€) : 79
Storage : -20°C ± 5°C
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