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ACTIVE PHARMA INGREDIENTS

12 API Suppliers, 7 USDMF, 3 EU WC, 4 KDMF, 6 NDC API, 7 Listed Suppliers, $ API Reference Price

12 API Suppliers
7 USDMF
3 EU WC
4 KDMF
6 NDC API
7 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

70 FDF Dossiers, 2 FDA Orange Book, 29 Europe, 12 Australia, 19 South Africa, 8 Listed Dossiers

70 FDF Dossiers
2 FDA Orange Book
29 Europe
12 Australia
19 South Africa
8 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 9 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
9 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 29 Finished Drug Prices, 3 Annual Reports

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2 US Medicaid Prescriptions
29 Finished Drug Prices
3 Annual Reports

MARKET PLACE

3 APIs, 5 FDF Dossiers

marketPlace
3 APIs
5 FDF Dossiers

PATENTS & EXCLUSIVITIES

6 US Patents

patents
6 US Patents

REF. STANDARDS & IMPURITIES

5 USP , 6 Others

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5 USP
6 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Inke Granisetron

Synopsis

ACTIVE PHARMA INGREDIENTS

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NDC API

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API REF. PRICE (USD/KG)

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FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

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REF. STANDARDS OR IMPURITIES

EDQM

USP

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PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

7,284,730

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

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Chemistry

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Also known as: Granisetron, 109889-09-0, Exo-granisetron (granisetron impurity f), 1364914-39-5, 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide, Granisetronum [inn-latin]

Molecular Formula

C₁₈H₂₄N₄O

Molecular Weight

312.4 g/mol

InChI Key

MFWNKCLOYSRHCJ-UHFFFAOYSA-N

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

1 2D Structure

Granisetron

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide

2.1.2 InChI

InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)

2.1.3 InChI Key

MFWNKCLOYSRHCJ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 1-methyl-n-(endo-9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1h-indazole-3-carboxamide

2. 1h-indazole-3-carboxamide, 1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl

3. 1h-indazole-3-carboxamide, 1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, Endo-

4. Brl 43694

5. Brl 43694a

6. Brl-43694

7. Brl-43694a

8. Brl43694

9. Brl43694a

10. Granisetron

11. Granisetron Hydrochloride

12. Granisetron Monohydrochloride

13. Hydrochloride, Granisetron

14. Kytril

15. Monohydrochloride, Granisetron

2.2.2 Depositor-Supplied Synonyms

1. Granisetron

2. 109889-09-0

3. Exo-granisetron (granisetron Impurity F)

4. 1364914-39-5

5. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide

6. Granisetronum [inn-latin]

7. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1h-indazole-3-carboxamide

8. Brl 43694

9. Granisetron-d3

10. Granisetron Base

11. [3h]-granisetron

12. Ly-278584

13. [3h]granisetron

14. Apf-530

15. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1h-indazole-3-carboxamide

16. 1-methyl-n-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1h-indazole-3-carboxamide

17. [3h]-brl-43694

18. Schembl445223

19. Chembl289469

20. Chembl519643

21. Gtpl2292

22. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide

23. Dtxsid50861188

24. Chebi:184693

25. Bcp10022

26. Ex-a1291

27. Hy-b0071

28. Bbl036319

29. Bdbm50000483

30. Pdsp1_001266

31. Pdsp2_001250

32. Stl483411

33. Akos015895362

34. Ab07494

35. Cs-1509

36. Sdccgsbi-0633801.p001

37. Ncgc00186041-01

38. Ncgc00186041-09

39. Ls-14665

40. Ft-0626805

41. Ab01274752-01

42. Ab01274752_02

43. Ab01274752_03

44. Aa-504/10505045

45. L000281

46. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-7-yl)indazole-3-carboxamide

47. 1-methyl-1h-indazole-3-carboxylic Acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide

48. 1-methyl-1h-indazole-3-carboxylic Acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide

49. 1-methyl-n-((1s,5r)-9-methyl-9-aza-bicyclo[3.3.1]nonan-3-yl)-1h-indazole-3-carboxamide

50. N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1-methyl-1h-indazole-3-carboxamide

51. (brl 43694)1-methyl-1h-indazole-3-carboxylic Acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide

52. (granisetron)1-methyl-1h-indazole-3-carboxylic Acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide

53. 1-methyl-1h-indazole-3-carboxylic Acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide(brl 43694)

54. 1-methyl-1h-indazole-3-carboxylic Acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide(granisetron)

55. 2-(9-methyl-3,9-diaza-bicyclo[3.3.1]non-3-yl)-1-(1-methyl-1h-indol-3-yl)-ethanone(granisetron)

2.3 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₄N₄O
Molecular Weight	312.4 g/mol
XLogP3	2.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	312.19501140 g/mol
Monoisotopic Mass	312.19501140 g/mol
Topological Polar Surface Area	50.2 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	442
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Prevention of nausea and vomiting in patients receiving moderately or highly emetogenic chemotherapy, with or without cisplatin, for up to five consecutive days.

Sancuso may be used in patients receiving their first chemotherapy regimen or in patients who have previously received chemotherapy.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Serotonin 5-HT3 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin-3 Receptor Antagonist [EPC]; Serotonin 3 Receptor Antagonists [MoA]

5.3 ATC Code

A04AA02

A - Alimentary tract and metabolism

A04 - Antiemetics and antinauseants

A04A - Antiemetics and antinauseants

A04AA - Serotonin (5ht3) antagonists

A04AA02 - Granisetron

API SUPPLIERS

01

Inke S.A

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Exhibiting

Inke S.A: APIs manufacturing plant.

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Spain

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CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

02

Seqens

France

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DDL Conference

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

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France

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USDMF

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03

Dr. Reddy's Laboratories

India

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Chromo Laboratories

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API Reference Price

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