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Chemistry

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Also known as: Egcg, 989-51-5, Epigallocatechin gallate, Epigallocatechin 3-gallate, Tea catechin, Epigallocatechin-3-gallate
Molecular Formula
C22H18O11
Molecular Weight
458.4  g/mol
InChI Key
WMBWREPUVVBILR-WIYYLYMNSA-N
FDA UNII
BQM438CTEL

Green Tea Extract
Epigallocatechin Gallate is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is under study as a potential cancer chemopreventive agent. (NCI)
1 2D Structure

Green Tea Extract

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
2.1.2 InChI
InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
2.1.3 InChI Key
WMBWREPUVVBILR-WIYYLYMNSA-N
2.1.4 Canonical SMILES
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
2.1.5 Isomeric SMILES
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
2.2 Other Identifiers
2.2.1 UNII
BQM438CTEL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Egcg Cpd

2. Epigallo-catechin Gallate

3. Epigallocatechin Gallate

4. Epigallocatechin-3-gallate

5. Epigallocatechin-3-o-gallate

2.3.2 Depositor-Supplied Synonyms

1. Egcg

2. 989-51-5

3. Epigallocatechin Gallate

4. Epigallocatechin 3-gallate

5. Tea Catechin

6. Epigallocatechin-3-gallate

7. (-)-epigallocatechin-3-o-gallate

8. Teavigo

9. Epigallocatechin-3-monogallate

10. (-)-epigallocatechin 3-gallate

11. (-)-epigallocatechol Gallate

12. Catechin Deriv.

13. Pf-egcg 90

14. Green Tea Extract

15. (2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate

16. Nvp-xaa 723

17. Bqm438ctel

18. (2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2h-chromen-3-yl 3,4,5-trihydroxybenzoate

19. [(2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2h-chromen-3-yl] 3,4,5-trihydroxybenzoate

20. Chebi:4806

21. Chembl297453

22. [(2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate

23. Dsstox_cid_567

24. Dsstox_rid_78830

25. Dsstox_gsid_29889

26. (2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2h-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate

27. Benzoic Acid, 3,4,5-trihydroxy-, (2r,3r)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-3-yl Ester

28. Cas-989-51-5

29. Smr000449288

30. Ccris 3729

31. Sr-01000759328

32. Unii-bqm438ctel

33. L-epigallocatechin Gallate

34. Epigallocate

35. Epigalocatechin Gallate

36. (-)-egcg

37. Epigallocic Acid

38. Teatannin Ii

39. 2kdh

40. 3oob

41. 4awm

42. (-)-cis-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-1(2h)-benzopyran-3,5,7-triol 3-gallate

43. (-)-epigallocatechin 3-o-gallate

44. Kdh

45. Epigallocatechol, 3-gallate, (-)-

46. (-)-epigallocatechin Gallate (egcg)

47. Epigallocatcchin Gallate

48. Epigallocatechin-gallate

49. Epigallocatechol Gallate

50. Spectrum_000316

51. Specplus_000277

52. Spectrum2_000168

53. Spectrum3_000244

54. Spectrum4_001541

55. Spectrum5_000102

56. Galloyl-l-epigallocatechol

57. Egcg [who-dd]

58. Egcg [mi]

59. 3-o-galloylepigallocatechin

60. (-)-epigallocatechin Gallat

61. (-)-epigallocatehin Gallate

62. Schembl35258

63. Bspbio_001628

64. Epigallocatechin-gallate-(-)

65. Kbiogr_002002

66. Kbioss_000796

67. Spectrum210239

68. Cid_65064

69. Mls000758300

70. Mls001424000

71. Divk1c_006373

72. Spbio_000035

73. Epigallocatechin Monogallate, B

74. Gtpl7002

75. Megxp0_001166

76. Dtxsid1029889

77. Acon1_001054

78. Kbio1_001317

79. Kbio2_000796

80. Kbio2_003364

81. Kbio2_005932

82. Kbio3_001128

83. (-)-cis-3,3',4',5,5',7-hexahydroxy-flavane-3-gallate

84. Hms2051k21

85. Hms3649e08

86. 3-o-galloyl-(-)-epigallocatechin

87. Zinc3870412

88. Epigallocatechin 3-o-gallate

89. Tox21_201468

90. Tox21_303457

91. Bdbm50070942

92. Ccg-38378

93. Fr-109

94. Lmpk12030005

95. S2250

96. Akos015918182

97. Cs-1258

98. Db12116

99. Ds-9030

100. Epigallocatechin Gallate [inci]

101. Nc00078

102. Sdccgmls-0066550.p001

103. (-)-epigallocatechin Gallate, >=95%

104. (-)-epigallocatechin-3-gallate; Egcg

105. Ncgc00164319-01

106. Ncgc00164319-02

107. Ncgc00164319-03

108. Ncgc00164319-04

109. Ncgc00164319-06

110. Ncgc00257243-01

111. Ncgc00259019-01

112. (-)-epigallocatechin Gallate (85% (-)-epigallocatechin Gallate, 10% (-)-epigallocatechin, 5% (-)- Epicatechin Gallate)

113. Ac-34075

114. Bp-30205

115. Hy-13653

116. E0694

117. N1874

118. Sw197458-3

119. C09731

120. M01719

121. (-)-epigallocatechin Gallate, >=97.0% (hplc)

122. (-)-epigallocatechin Gallate, Analytical Standard

123. 989e515

124. A845931

125. Gallic Acid, 3-ester With Epigallocatechol, (-)-

126. Q393339

127. Sr-01000946601

128. (-)-epigallocatechin-3-o-gallate [usp-rs]

129. Q-100914

130. Sr-01000759328-5

131. Sr-01000759328-6

132. Sr-01000946601-1

133. Epigallocatechin-3-gallate 1000 Microg/ml In Acetonitrile

134. (-)-epigallocatechin Gallate, >=80% (hplc), From Green Tea

135. Epigallocatechin Gallate, Primary Pharmaceutical Reference Standard

136. (-)-epigallocatechin-3-o-gallate, United States Pharmacopeia (usp) Reference Standard

137. (2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl3,4,5-trihydroxybenzoate

138. [5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 2,3,4-trihydroxybenzoate

139. Epigallocatechin Gallate, Pharmaceutical Secondary Standard; Certified Reference Material

140. (-)-cis-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2h)-benzopyran-3-yl Gallate

141. (-)-epigallocatechin Gallate (85% (-)-epigallocatechin Gallate, 10% (-)-epigallocatechin, 5% (-)-epicatechin Gallate)

142. (-)-epigallocatechin-3-o-gallate (egcg) (constituent Of Powdered Decaffeinated Green Tea Extract) [dsc]

143. (2r,3r)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2h-chromen-3-yl-3,4,5-trihydroxybenzoate

144. 3,4,5-trihydroxybenzoic Acid (2r,3r)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-3-yl Ester

145. 3,4-dihydro-5,7-dihydroxy-2r-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-3r-yl-3,4,5-trihydroxybenzoate

146. Benzoic Acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-3-yl Ester, (2r-cis)-

147. Benzoic Acid, 3,4,5-trihydroxy-,(2r,3r)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2h-1-benzopyran-3-yl Ester

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 458.4 g/mol
Molecular Formula C22H18O11
XLogP31.2
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass458.08491139 g/mol
Monoisotopic Mass458.08491139 g/mol
Topological Polar Surface Area197 Ų
Heavy Atom Count33
Formal Charge0
Complexity667
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)


Neuroprotective Agents

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)


Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


Antimutagenic Agents

Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved. (See all compounds classified as Antimutagenic Agents.)


4.2 Metabolism/Metabolites

(-)-Epigallocatechin gallate has known human metabolites that include (-)-Epigallocatechin gallate, 3p-hydroxy-glucuronide and (-)-Epigallocatechin gallate, 4p-hydroxy-glucuronide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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[{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701628200,"product":"GREEN TEA EXTRACT (70% POLYPHENOLS)","address":"PLOT NO.A-177,ROAD NO.16-Z,WAGLEINDL.EST,","city":"THANE, MAHARASHTRA","supplier":"MEYER ORGANICS","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"PT,VITABIOTICS HEALTHCARE","customerCountry":"INDONESIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"20.7","totalValueFC":"60.1","currency":"USD","unitRateINR":1666.6666666666667,"date":"04-Dec-2023","totalValueINR":"5000","totalValueInUsd":"60.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"5795367","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO.A-177,ROAD NO.16-Z,WAGLEINDL.EST,, THANE, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709490600,"product":"GREEN TEA EXTRACT (NATURAL CAFFEINE 98%) LOT NO:PTHX\/CAF\/380\/24","address":"Q6, KSSIDC INDUSTRIAL ESTATE,,2ND","city":"BANGALORE,KARNATAKA","supplier":"PURE TRUHERB PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"LOS ANGELES","customer":"BLUE CALIFORNIA","customerCountry":"UNITED STATES","quantity":"1600.00","actualQuantity":"1600","unit":"KGS","unitRateFc":"55","totalValueFC":"80811.8","currency":"USD","unitRateINR":4193.9189999999999,"date":"04-Mar-2024","totalValueINR":"6710270.4","totalValueInUsd":"80811.8","indian_port":"Bangalore Air","hs_no":"29393000","bill_no":"8051479","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"Q6, KSSIDC INDUSTRIAL ESTATE,,2ND, BANGALORE,KARNATAKA","customerAddress":""}]
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ABOUT THIS PAGE

Green Tea Extract Manufacturers

A Green Tea Extract manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Green Tea Extract, including repackagers and relabelers. The FDA regulates Green Tea Extract manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Green Tea Extract API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Green Tea Extract manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Green Tea Extract Suppliers

A Green Tea Extract supplier is an individual or a company that provides Green Tea Extract active pharmaceutical ingredient (API) or Green Tea Extract finished formulations upon request. The Green Tea Extract suppliers may include Green Tea Extract API manufacturers, exporters, distributors and traders.

click here to find a list of Green Tea Extract suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Green Tea Extract USDMF

A Green Tea Extract DMF (Drug Master File) is a document detailing the whole manufacturing process of Green Tea Extract active pharmaceutical ingredient (API) in detail. Different forms of Green Tea Extract DMFs exist exist since differing nations have different regulations, such as Green Tea Extract USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Green Tea Extract DMF submitted to regulatory agencies in the US is known as a USDMF. Green Tea Extract USDMF includes data on Green Tea Extract's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Green Tea Extract USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Green Tea Extract suppliers with USDMF on PharmaCompass.

Green Tea Extract GMP

Green Tea Extract Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Green Tea Extract GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Green Tea Extract GMP manufacturer or Green Tea Extract GMP API supplier for your needs.

Green Tea Extract CoA

A Green Tea Extract CoA (Certificate of Analysis) is a formal document that attests to Green Tea Extract's compliance with Green Tea Extract specifications and serves as a tool for batch-level quality control.

Green Tea Extract CoA mostly includes findings from lab analyses of a specific batch. For each Green Tea Extract CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Green Tea Extract may be tested according to a variety of international standards, such as European Pharmacopoeia (Green Tea Extract EP), Green Tea Extract JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Green Tea Extract USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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