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Synopsis

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Chemistry

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Also known as: 645-43-2, Guanethidine monosulfate, Ismelin, Ismelin sulfate, Guanethidine (sulfate), Guanethidine sulphae
Molecular Formula
C10H24N4O4S
Molecular Weight
296.39  g/mol
InChI Key
YUFWAVFNITUSHI-UHFFFAOYSA-N
FDA UNII
5UBY8Y002G

Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
1 2D Structure

Guanethidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid
2.1.2 InChI
InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
2.1.3 InChI Key
YUFWAVFNITUSHI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
5UBY8Y002G
2.3 Synonyms
2.3.1 MeSH Synonyms

1. ((2-hexahydro-1(2h)-azocinyl)ethyl)guanidine

2. Guanethidine

3. Guanethidine Monosulfate

4. Guanethidine Sulfate (1:1)

5. Guanethidine Sulfate (1:2)

6. Guanethidine Sulfate (2:1)

7. Guanethidine Sulfate (2:1), 14c-labeled

8. Ismelin

9. Isobarin

10. Monosulfate, Guanethidine

11. Octadine

12. Oktadin

13. Sulfate, Guanethidine

2.3.2 Depositor-Supplied Synonyms

1. 645-43-2

2. Guanethidine Monosulfate

3. Ismelin

4. Ismelin Sulfate

5. Guanethidine (sulfate)

6. Guanethidine Sulphae

7. 1-(2-(azocan-1-yl)ethyl)guanidine Sulfate

8. Guanethidine Monosulphate

9. 645-43-2 (sulfate)

10. 5uby8y002g

11. 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric Acid

12. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulfate (1:1)

13. Guanidine, [2-(hexahydro-1(2h)-azocinyl)ethyl]-, Sulfate (1:1)

14. Isobarin

15. Octadin

16. Octadine

17. Iporal

18. Guanetidin Sulfate

19. Guanethidinesulfate

20. 2-(octahydro-1-azocinyl)ethyl Guanidine Sulphate

21. Guanethidine Bisulfate

22. (2-(hexahydro-1(2h)-azocinyl)ethyl) Guanidine Hydrogen Sulfate

23. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1)

24. Ismelin Sulfate (2:1)

25. Su 5864 Sulfate (1:1)

26. Chebi:51016

27. Nsc29863

28. Guanethidine Monosulfate [usan]

29. Einecs 211-442-0

30. Unii-5uby8y002g

31. Isomelin

32. Guanethidine Sulfate (1:1)

33. N-(2-guanidino Ethyl)heptamethylenimine Sulfate

34. Prestwick_249

35. Ismelin (tn)

36. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate (2:1)

37. Guanethidine Monosulfate [usan:usp]

38. Azocine, Sulfate (2:1)

39. Chembl1345

40. Schembl51039

41. Guanethidine Monosulphate Usp

42. Guanethidine Sulfate (jp17)

43. Spectrum1500323

44. Guanethidine Monosulfate (usp)

45. Schembl11658850

46. Hms501k21

47. (2-(hexahydro-(2h)-azocin-1-yl)ethyl)guanidinium Sulphate

48. Dtxsid20110019

49. Hms1568p16

50. Hms1920b19

51. Hms2091j05

52. Hms3749o19

53. Pharmakon1600-01500323

54. Methyltriallylammoniumbromide

55. Hy-b0800

56. Ac-479

57. Ccg-39688

58. Guanethidine Monosulfate [mi]

59. Mfcd00035403

60. Nsc757045

61. S5496

62. Akos015856688

63. Akos026750543

64. Wln: T8ntj A2myzum & 2wsqq

65. Cs-3931

66. Nsc-757045

67. Guanethidine Monosulfate [mart.]

68. Guanethidine Monosulfate [vandf]

69. Guanethidine Monosulfate [usp-rs]

70. Guanethidine Monosulfate [who-dd]

71. Ncgc00094691-01

72. Ncgc00094691-02

73. As-57397

74. .beta.-1-azacyclooctylethylguanidine Sulfate

75. Ft-0603504

76. Guanethidine Monosulfate [ep Impurity]

77. D04382

78. Esimil Component Guanethidine Monosulfate

79. Guanethidine Monosulfate [ep Monograph]

80. Guanethidine Monosulfate [usp Monograph]

81. [2-(octahydro-1-azocinyl)ethyl]guanidine Sulfate

82. Guanethidine Monosulfate Component Of Esimil

83. N-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

84. Sr-05000001637

85. 1-[2-(azocan-1-yl)ethyl]guanidine (1/2h2so4)

86. Sr-05000001637-1

87. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

88. N''-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

89. Q27122277

90. N-[2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

91. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1).

92. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulphate (1:1).

93. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulphate (1:1)

94. Guanethidine Monosulfate, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 296.39 g/mol
Molecular Formula C10H24N4O4S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass296.15182643 g/mol
Monoisotopic Mass296.15182643 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count19
Formal Charge0
Complexity248
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)


Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)


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ABOUT THIS PAGE

Guanethidine Manufacturers

A Guanethidine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Guanethidine, including repackagers and relabelers. The FDA regulates Guanethidine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Guanethidine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Guanethidine Suppliers

A Guanethidine supplier is an individual or a company that provides Guanethidine active pharmaceutical ingredient (API) or Guanethidine finished formulations upon request. The Guanethidine suppliers may include Guanethidine API manufacturers, exporters, distributors and traders.

click here to find a list of Guanethidine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Guanethidine USDMF

A Guanethidine DMF (Drug Master File) is a document detailing the whole manufacturing process of Guanethidine active pharmaceutical ingredient (API) in detail. Different forms of Guanethidine DMFs exist exist since differing nations have different regulations, such as Guanethidine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Guanethidine DMF submitted to regulatory agencies in the US is known as a USDMF. Guanethidine USDMF includes data on Guanethidine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Guanethidine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Guanethidine suppliers with USDMF on PharmaCompass.

Guanethidine GMP

Guanethidine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Guanethidine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Guanethidine GMP manufacturer or Guanethidine GMP API supplier for your needs.

Guanethidine CoA

A Guanethidine CoA (Certificate of Analysis) is a formal document that attests to Guanethidine's compliance with Guanethidine specifications and serves as a tool for batch-level quality control.

Guanethidine CoA mostly includes findings from lab analyses of a specific batch. For each Guanethidine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Guanethidine may be tested according to a variety of international standards, such as European Pharmacopoeia (Guanethidine EP), Guanethidine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Guanethidine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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