All Manufacturers, Suppliers, Distributors and Exporters of Guanethidine with approved FDA Orange Book of Finished Dosage Form listed on PharmaCompass.com

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

JP

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 645-43-2, Guanethidine monosulfate, Ismelin, Ismelin sulfate, Guanethidine (sulfate), Guanethidine sulphae
Molecular Formula
C10H24N4O4S
Molecular Weight
296.39  g/mol
InChI Key
YUFWAVFNITUSHI-UHFFFAOYSA-N
FDA UNII
5UBY8Y002G

Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
1 2D Structure

Guanethidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid
2.1.2 InChI
InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
2.1.3 InChI Key
YUFWAVFNITUSHI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
5UBY8Y002G
2.3 Synonyms
2.3.1 MeSH Synonyms

1. ((2-hexahydro-1(2h)-azocinyl)ethyl)guanidine

2. Guanethidine

3. Guanethidine Monosulfate

4. Guanethidine Sulfate (1:1)

5. Guanethidine Sulfate (1:2)

6. Guanethidine Sulfate (2:1)

7. Guanethidine Sulfate (2:1), 14c-labeled

8. Ismelin

9. Isobarin

10. Monosulfate, Guanethidine

11. Octadine

12. Oktadin

13. Sulfate, Guanethidine

2.3.2 Depositor-Supplied Synonyms

1. 645-43-2

2. Guanethidine Monosulfate

3. Ismelin

4. Ismelin Sulfate

5. Guanethidine (sulfate)

6. Guanethidine Sulphae

7. 1-(2-(azocan-1-yl)ethyl)guanidine Sulfate

8. Guanethidine Monosulphate

9. 645-43-2 (sulfate)

10. 5uby8y002g

11. 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric Acid

12. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulfate (1:1)

13. Guanidine, [2-(hexahydro-1(2h)-azocinyl)ethyl]-, Sulfate (1:1)

14. Isobarin

15. Octadin

16. Octadine

17. Iporal

18. Guanetidin Sulfate

19. Guanethidinesulfate

20. 2-(octahydro-1-azocinyl)ethyl Guanidine Sulphate

21. Guanethidine Bisulfate

22. (2-(hexahydro-1(2h)-azocinyl)ethyl) Guanidine Hydrogen Sulfate

23. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1)

24. Ismelin Sulfate (2:1)

25. Su 5864 Sulfate (1:1)

26. Chebi:51016

27. Nsc29863

28. Guanethidine Monosulfate [usan]

29. Einecs 211-442-0

30. Unii-5uby8y002g

31. Isomelin

32. Guanethidine Sulfate (1:1)

33. N-(2-guanidino Ethyl)heptamethylenimine Sulfate

34. Prestwick_249

35. Ismelin (tn)

36. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate (2:1)

37. Guanethidine Monosulfate [usan:usp]

38. Azocine, Sulfate (2:1)

39. Chembl1345

40. Schembl51039

41. Guanethidine Monosulphate Usp

42. Guanethidine Sulfate (jp17)

43. Spectrum1500323

44. Guanethidine Monosulfate (usp)

45. Schembl11658850

46. Hms501k21

47. (2-(hexahydro-(2h)-azocin-1-yl)ethyl)guanidinium Sulphate

48. Dtxsid20110019

49. Hms1568p16

50. Hms1920b19

51. Hms2091j05

52. Hms3749o19

53. Pharmakon1600-01500323

54. Methyltriallylammoniumbromide

55. Hy-b0800

56. Ac-479

57. Ccg-39688

58. Guanethidine Monosulfate [mi]

59. Mfcd00035403

60. Nsc757045

61. S5496

62. Akos015856688

63. Akos026750543

64. Wln: T8ntj A2myzum & 2wsqq

65. Cs-3931

66. Nsc-757045

67. Guanethidine Monosulfate [mart.]

68. Guanethidine Monosulfate [vandf]

69. Guanethidine Monosulfate [usp-rs]

70. Guanethidine Monosulfate [who-dd]

71. Ncgc00094691-01

72. Ncgc00094691-02

73. As-57397

74. .beta.-1-azacyclooctylethylguanidine Sulfate

75. Ft-0603504

76. Guanethidine Monosulfate [ep Impurity]

77. D04382

78. Esimil Component Guanethidine Monosulfate

79. Guanethidine Monosulfate [ep Monograph]

80. Guanethidine Monosulfate [usp Monograph]

81. [2-(octahydro-1-azocinyl)ethyl]guanidine Sulfate

82. Guanethidine Monosulfate Component Of Esimil

83. N-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

84. Sr-05000001637

85. 1-[2-(azocan-1-yl)ethyl]guanidine (1/2h2so4)

86. Sr-05000001637-1

87. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

88. N''-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

89. Q27122277

90. N-[2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

91. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1).

92. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulphate (1:1).

93. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulphate (1:1)

94. Guanethidine Monosulfate, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 296.39 g/mol
Molecular Formula C10H24N4O4S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass296.15182643 g/mol
Monoisotopic Mass296.15182643 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count19
Formal Charge0
Complexity248
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)


Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)


API SUPPLIERS

read-more
read-more

01

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Luxepack
Not Confirmed
arrow

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

arrow
Luxepack
Not Confirmed
USDMF Inactive-api CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
blank

02

Corden Pharma Bergamo S.p.A

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Luxepack
Not Confirmed
arrow

Corden Pharma Bergamo S.p.A

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

arrow
Luxepack
Not Confirmed
USDMF Inactive-api CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

read-more
read-more

01

Actavis Inc

Ireland
Discovery on Target
Not Confirmed
arrow

Actavis Inc

Ireland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : GUANETHIDINE MONOSULFATE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 10MG SULFATE

Packaging :

Approval Date : 1985-03-26

Application Number : 86113

Regulatory Info : DISCN

Registration Country : USA

blank

02

Actavis Inc

Ireland
Discovery on Target
Not Confirmed
arrow

Actavis Inc

Ireland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : GUANETHIDINE MONOSULFATE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 25MG SULFATE

Packaging :

Approval Date : 1985-03-26

Application Number : 86114

Regulatory Info : DISCN

Registration Country : USA

blank

03

Discovery on Target
Not Confirmed
arrow
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : ISMELIN

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 10MG SULFATE

Packaging :

Approval Date : 1982-01-01

Application Number : 12329

Regulatory Info : DISCN

Registration Country : USA

blank

04

Discovery on Target
Not Confirmed
arrow
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : ISMELIN

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 25MG SULFATE

Packaging :

Approval Date : 1982-01-01

Application Number : 12329

Regulatory Info : DISCN

Registration Country : USA

blank

05

Discovery on Target
Not Confirmed
arrow
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE; HYDROCHLOROTHIAZIDE

Brand Name : ESIMIL

Dosage Form : TABLET;ORAL

Dosage Strength : 10MG;25MG

Packaging :

Approval Date : 1982-01-01

Application Number : 13553

Regulatory Info : DISCN

Registration Country : USA

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDA Orange Book

read-more
read-more

01

WATSON LABS

Ireland
Discovery on Target
Not Confirmed
arrow

WATSON LABS

Ireland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : GUANETHIDINE MONOSULFATE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 10MG SULFATE

Approval Date : 1985-03-26

Application Number : 86113

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

02

WATSON LABS

Ireland
Discovery on Target
Not Confirmed
arrow

WATSON LABS

Ireland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : GUANETHIDINE MONOSULFATE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 25MG SULFATE

Approval Date : 1985-03-26

Application Number : 86114

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

03

NOVARTIS

Switzerland
Discovery on Target
Not Confirmed
arrow

NOVARTIS

Switzerland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : ISMELIN

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 10MG SULFATE

Approval Date : 1982-01-01

Application Number : 12329

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

04

NOVARTIS

Switzerland
Discovery on Target
Not Confirmed
arrow

NOVARTIS

Switzerland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE

Brand Name : ISMELIN

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 25MG SULFATE

Approval Date : 1982-01-01

Application Number : 12329

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

05

NOVARTIS

Switzerland
Discovery on Target
Not Confirmed
arrow

NOVARTIS

Switzerland
arrow
Discovery on Target
Not Confirmed

GUANETHIDINE MONOSULFATE; HYDROCHLOROTHIAZIDE

Brand Name : ESIMIL

Dosage Form : TABLET;ORAL

Dosage Strength : 10MG;25MG

Approval Date : 1982-01-01

Application Number : 13553

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

REF. STANDARDS & IMPURITIES

Upload your portfolio for free, ask us

ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty