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Chemistry

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Also known as: 29110-48-3, Guanfacine hcl, Tenex, Intuniv, Guanfacine (hydrochloride), N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride
Molecular Formula
C9H10Cl3N3O
Molecular Weight
282.5  g/mol
InChI Key
DGFYECXYGUIODH-UHFFFAOYSA-N
FDA UNII
PML56A160O

Guanfacine
A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
1 2D Structure

Guanfacine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide;hydrochloride
2.1.2 InChI
InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
2.1.3 InChI Key
DGFYECXYGUIODH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
PML56A160O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bs 100 141

2. Bs-100-141

3. Bs100141

4. Estulic

5. Guanfacine

6. Guanfacine Monohydrochloride

7. Hydrochloride, Guanfacine

8. Lon798

9. Monohydrochloride, Guanfacine

10. Tenex

2.3.2 Depositor-Supplied Synonyms

1. 29110-48-3

2. Guanfacine Hcl

3. Tenex

4. Intuniv

5. Guanfacine (hydrochloride)

6. N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide Hydrochloride

7. Estulic

8. Bs 100-141

9. 29520-14-7

10. N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride

11. Spd503

12. N-amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride

13. N-amidino-2-(2,6-dichlorophenyl)acetamide Monohydrochloride

14. Guafacine Hydrochloride

15. Bs-100-141

16. Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, Monohydrochloride

17. Spd 503

18. Mls000069745

19. Pml56a160o

20. Smr000058453

21. 29110-48-3 (hcl)

22. Dsstox_cid_25157

23. Dsstox_rid_80708

24. Dsstox_gsid_45157

25. Connexyn

26. Lon 798

27. N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide;hydrochloride

28. Cas-29520-14-7

29. Guanfacinehcl

30. Tenex (tn)

31. Guanfacinehydrochloride

32. Sr-01000075893

33. Ncgc00015469-05

34. Einecs 249-443-3

35. N-(aminoiminomethyl)-2,6-dichlorophenylacetamide Monohydrochloride

36. Unii-pml56a160o

37. Spd-503

38. Prestwick_740

39. Guanfacine Hydrochloride (jan/usp)

40. Intuniv (tn)

41. Mfcd00798230

42. Guanfacine Hydrochloride [usan:usp:jan]

43. Opera_id_1928

44. N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide Hydrochloride

45. Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, Hydrochloride (1:1)

46. G 1043

47. Schembl41681

48. Mls001077329

49. Mls002222252

50. [(2,6-dichlorophenyl)acetyl]guanidine Hydrochloride

51. Chebi:5559

52. Chembl1200494

53. Dtxsid2045157

54. Schembl15603414

55. Hms1569c19

56. Hms3747e15

57. Pharmakon1600-01505435

58. Bcp21710

59. N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide Hydrochloride

60. Tox21_110159

61. Tox21_500519

62. Guanfacine Hydrochloride [mi]

63. Nsc759121

64. S4693

65. Guanfacine Hydrochloride [jan]

66. Akos015966858

67. Akos030242245

68. Tox21_110159_1

69. Ccg-213439

70. Ccg-220339

71. Cs-1254

72. Guanfacine Hydrochloride [usan]

73. Lp00519

74. Guanfacine Hydrochloride [mart.]

75. Guanfacine Hydrochloride [vandf]

76. Guanfacine Hydrochloride [usp-rs]

77. Guanfacine Hydrochloride [who-dd]

78. Ncgc00015469-09

79. Ncgc00093914-01

80. Ncgc00093914-02

81. Ncgc00180965-01

82. Ncgc00261204-01

83. As-12253

84. Hy-17416

85. Guanfacine Hydrochloride, >=98% (hplc)

86. Bs100-141

87. Db-047525

88. Eu-0100519

89. Ft-0630546

90. Ft-0698181

91. G0414

92. Guanfacine Hydrochloride [orange Book]

93. D00606

94. Guanfacine Hydrochloride [usp Monograph]

95. T72238

96. A826918

97. J-017395

98. S-877503

99. Sr-01000075893-1

100. Sr-01000075893-3

101. Sr-01000075893-6

102. Q27286641

103. N-carbamimidoyl-2-(2,6-dichlorophenyl)-acetamide Hydrochloride

104. Guanfacine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

105. Guanfacine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

106. N-[bis(azanyl)methylidene]-2-[2,6-bis(chloranyl)phenyl]ethanamide Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 282.5 g/mol
Molecular Formula C9H10Cl3N3O
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass280.988945 g/mol
Monoisotopic Mass280.988945 g/mol
Topological Polar Surface Area81.5 Ų
Heavy Atom Count16
Formal Charge0
Complexity256
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameGuanfacine hydrochloride
Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
Active IngredientGuanfacine hydrochloride
Dosage FormTablet, extended release; Tablet
Routeoral; Oral
Strengtheq 4mg base; eq 2mg base; 1mg; eq 1mg base; eq 3mg base; 4mg; 2mg; 3mg
Market StatusTentative Approval; Prescription
CompanyTwi Pharms; Epic Pharma; Teva Pharms Usa; Sandoz; Watson Labs; Actavis Elizabeth; Amneal Pharm; Mylan

2 of 4  
Drug NameTenex
PubMed HealthGuanfacine (By mouth)
Drug ClassesAntihypertensive, Cardiovascular Agent, Central Nervous System Agent
Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
Active IngredientGuanfacine hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 2mg base; eq 1mg base
Market StatusPrescription
CompanyPromius Pharma

3 of 4  
Drug NameGuanfacine hydrochloride
Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
Active IngredientGuanfacine hydrochloride
Dosage FormTablet, extended release; Tablet
Routeoral; Oral
Strengtheq 4mg base; eq 2mg base; 1mg; eq 1mg base; eq 3mg base; 4mg; 2mg; 3mg
Market StatusTentative Approval; Prescription
CompanyTwi Pharms; Epic Pharma; Teva Pharms Usa; Sandoz; Watson Labs; Actavis Elizabeth; Amneal Pharm; Mylan

4 of 4  
Drug NameTenex
PubMed HealthGuanfacine (By mouth)
Drug ClassesAntihypertensive, Cardiovascular Agent, Central Nervous System Agent
Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
Active IngredientGuanfacine hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 2mg base; eq 1mg base
Market StatusPrescription
CompanyPromius Pharma

4.2 Drug Indication

Intuniv is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents 6 17 years old for whom stimulants are not suitable, not tolerated or have been shown to be ineffective.

Intuniv must be used as a part of a comprehensive ADHD treatment programme, typically including psychological, educational and social measures.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Central alpha-2 Adrenergic Agonist [EPC]; Adrenergic alpha2-Agonists [MoA]
5.3 ATC Code

C02AC02


API SUPPLIERS

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Axplora

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Medichem S.A

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Procos

Italy

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Procos

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Zhejiang Guobang Pharmaceutical

China

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Zhejiang Guobang Pharmaceutical

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Quimica Sintetica

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Quimica Sintetica

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Unichem Laboratories Limited

India

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Unichem Laboratories Limited

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Jubilant Generics

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Torrent Pharmaceuticals Limited

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Torrent Pharmaceuticals Limited

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PharmaBlock Sciences

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Sandoz B2B

Switzerland

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Medichem Sa

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DMF Review : Complete

Rev. Date : 2013-02-26

Pay. Date : 2013-02-05

DMF Number : 8590

Submission : 1990-06-12

Status : Active

Type : II

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Jubilant Pharmova Ltd

India

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Rev. Date : 2016-11-18

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Procos Spa

Italy

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Procos Spa

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Pay. Date : 2014-06-19

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Quimica Sintetica Sa

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SPAINSDNF ES","customerAddress":"PLOT NO 2A & 2B, BIOTECH PARK,,PHA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701369000,"product":"GUANFACINE HCL USP","address":"221, GOREGAON-MULUND LINK ROAD,","city":"BHANDUP WEST, MUMBAI","supplier":"PROCOS","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"4400","totalValueFC":"22226.5","currency":"USD","unitRateINR":"370040","date":"01-Dec-2023","totalValueINR":"1850200","totalValueInUsd":"22226.5","indian_port":"Bombay Air","hs_no":"29252990","bill_no":"9021462","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"VIA MATTEOTTI 24928062 CAMERI (NO)ITALY IT","customerAddress":"221, GOREGAON-MULUND LINK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703097000,"product":"GUANFACINE HCL USP (CAS NO: 29110-48-3)","address":"SP BIOTECH,PARK-PHASE-I,BLOCK-I,TU","city":"","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"FINOSO PHARMA PRIVATE ","customerCountry":"INDIA","quantity":"14.40","actualQuantity":"14.4","unit":"KGS","unitRateFc":"4500","totalValueFC":"65622.7","currency":"USD","unitRateINR":"379350","date":"21-Dec-2023","totalValueINR":"5462640","totalValueInUsd":"65622.7","indian_port":"Hyderabad Air","hs_no":"29252990","bill_no":"9332374","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"MANUEL POMBO ANGULO 283RD FLOOR , 28050 MADRIDSDNF ES","customerAddress":"SP BIOTECH,PARK-PHASE-I,BLOCK-I,TU"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706293800,"product":"GUANFACINE HCL (GUANFACINE HYDROCHLORIDE USP)","address":"98, GOVT.INDUSTRIAL AREA,","city":"MUMBAI.","supplier":"PROCOS","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"AJANTA PHARMA LIMITED","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"4800","totalValueFC":"38856.6","currency":"USD","unitRateINR":"403680","date":"27-Jan-2024","totalValueINR":"3229440","totalValueInUsd":"38856.6","indian_port":"Bombay Air","hs_no":"29252990","bill_no":"9854183","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"VIA MATTEOTTI 249 28062 CAMERI (NO)ITALYSDNF Italy","customerAddress":"98, GOVT.INDUSTRIAL AREA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718130600,"product":"GUANFACINE HCL USP","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"INDIA","quantity":"7.00","actualQuantity":"7","unit":"KGS","unitRateFc":"4000","totalValueFC":"28275.2","currency":"USD","unitRateINR":"337200","date":"12-Jun-2024","totalValueINR":"2360400","totalValueInUsd":"28275.2","indian_port":"Bombay Air","hs_no":"29252990","bill_no":"3960734","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"Manuel Pombo Angulo, 28, 3rd floor28050 Madrid - SpainSDNF Spain","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723833000,"product":"GUANFACINE HYDROCHLORIDE USP","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALEMBIC PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"4.18","actualQuantity":"4.18","unit":"KGS","unitRateFc":"4400","totalValueFC":"18605","currency":"USD","unitRateINR":"373340","date":"17-Aug-2024","totalValueINR":"1560561.2","totalValueInUsd":"18605","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"5114069","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CHEMO S.A.LUGANO BRANCH,VIA F.PELLI17,P.O.BOX 6901 LUGANO,SDNF SWITZERLAND","customerAddress":"ALEMBIC ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"GUANFACINE HYDROCHLORIDE USP","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ALEMBIC PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"1.25","actualQuantity":"1.25","unit":"KGS","unitRateFc":"4400","totalValueFC":"5537.5","currency":"USD","unitRateINR":"372240","date":"01-Oct-2024","totalValueINR":"465300","totalValueInUsd":"5537.5","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"5904792","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CHEMO S.A.LUGANO BRANCH,VIA F.PELLI 17,P.O.BOX 6901 LUGANO, SDNF SWITZERLAND","customerAddress":"ALEMBIC ROAD"}]
16-Apr-2021
01-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Europe

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01

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

guanfacinhydroklorid

Brand Name : Intuniv

Dosage Form : PROLONGED-RELEASE TABLET

Dosage Strength : 2 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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02

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

guanfacinhydroklorid

Brand Name : Intuniv

Dosage Form : PROLONGED-RELEASE TABLET

Dosage Strength : 4 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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03

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

guanfacinhydroklorid

Brand Name : Intuniv

Dosage Form : PROLONGED-RELEASE TABLET

Dosage Strength : 1 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacine

Brand Name : Intuniv

Dosage Form : Depottablett

Dosage Strength : 1 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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05

Pharma, Lab & Chemical Expo
Not Confirmed
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arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacine

Brand Name : Intuniv

Dosage Form : Depottablett

Dosage Strength : 4 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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06

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacine hydrochloride

Brand Name : Intuniv

Dosage Form : Depot tablet

Dosage Strength : 4 mg

Packaging : Blisterpakning 28item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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07

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacine hydrochloride

Brand Name : Intuniv

Dosage Form : Depot tablet

Dosage Strength : 1 mg

Packaging : Blisterpakning 28item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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08

Pharma, Lab & Chemical Expo
Not Confirmed
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arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacinum

Brand Name : Intuniv

Dosage Form : Ret Tabl

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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09

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacinum

Brand Name : Intuniv

Dosage Form : Ret Tabl

Dosage Strength : 2mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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10

Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Guanfacinum

Brand Name : Intuniv

Dosage Form : Ret Tabl

Dosage Strength : 3mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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Patents & EXCLUSIVITIES

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Health Canada Patents

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01

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Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
Not Confirmed

Guanfacine

Brand Name : INTUNIV XR

Patent Number : 2432178

Filing Date : 2001-12-20

Strength per Unit : 1 mg

Dosage Form : Extended Release Tablet

Human Or VET : Human

Route of Administration : Oral

Patent Expiration Date : 2021-12-20

Date Granted : 2010-04-20

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02

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Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
Not Confirmed

Guanfacine

Brand Name : INTUNIV XR

Patent Number : 2432178

Filing Date : 2001-12-20

Strength per Unit : 2 mg

Dosage Form : Extended Release Tablet

Human Or VET : Human

Route of Administration : Oral

Patent Expiration Date : 2021-12-20

Date Granted : 2010-04-20

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03

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Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
Not Confirmed

Guanfacine

Brand Name : INTUNIV XR

Patent Number : 2432178

Filing Date : 2001-12-20

Strength per Unit : 3 mg

Dosage Form : Extended Release Tablet

Human Or VET : Human

Route of Administration : Oral

Patent Expiration Date : 2021-12-20

Date Granted : 2010-04-02

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04

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Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
Not Confirmed

Guanfacine

Brand Name : INTUNIV XR

Patent Number : 2432178

Filing Date : 2001-12-20

Strength per Unit : 4 mg

Dosage Form : Extended Release Tablet

Human Or VET : Human

Route of Administration : Oral

Patent Expiration Date : 2021-12-20

Date Granted : 2010-04-20

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