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Chemistry

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Also known as: Asn002, Asn-002, 1425381-60-7, Gusacitinib [inn], Gusacitinib [usan], En3351
Molecular Formula
C24H28N8O2
Molecular Weight
460.5  g/mol
InChI Key
NLFLXLJXEIUQDL-UHFFFAOYSA-N
FDA UNII
4801QYW816

Gusacitinib
Gusacitinib is under investigation in clinical trial NCT02550678 (A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma).
1 2D Structure

Gusacitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile
2.1.2 InChI
InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
2.1.3 InChI Key
NLFLXLJXEIUQDL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
2.2 Other Identifiers
2.2.1 UNII
4801QYW816
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(4-(4-(4-hydroxy-piperidin-1-yl)-phenylamino)-5-oxo-5,6-dihydro-pyrimido(4,5-d)pyridazin-2-yl)-piperidin-4-yl-acetonitrile

2. 4-piperidineacetonitrile, 1-(5,6-dihydro-4-((4-(4-hydroxy-1-piperidinyl)phenyl)amino)-5-oxopyrimido(4,5-d)pyridazin-2-yl)-

3. Asn-002

4. Asn002

2.3.2 Depositor-Supplied Synonyms

1. Asn002

2. Asn-002

3. 1425381-60-7

4. Gusacitinib [inn]

5. Gusacitinib [usan]

6. En3351

7. 4801qyw816

8. En-3351

9. 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6h-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile

10. 1-(4-(4-(4-hydroxy-piperidin-1-yl)-phenylamino)-5-oxo-5,6-dihydro-pyrimido(4,5-d)pyridazin-2-yl)-piperidin-4-yl-acetonitrile

11. 4-piperidineacetonitrile, 1-(5,6-dihydro-4-((4-(4-hydroxy-1-piperidinyl)phenyl)amino)-5-oxopyrimido(4,5-d)pyridazin-2-yl)-

12. Gusacitinib (usan/inn)

13. Gusacitinib [who-dd]

14. Chembl4594275

15. Schembl14717111

16. Unii-4801qyw816

17. Gtpl10000

18. Asn-002asn-002

19. Bcp31675

20. Ex-a2668

21. Nsc818003

22. Who 10976

23. Nsc-818003

24. Example 189 [wo2013028818a1]

25. Hy-103018

26. Asn-002; Asn 002; Asn002

27. Cs-0023113

28. D11676

29. F78024

30. 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile

2.4 Create Date
2013-03-21
3 Chemical and Physical Properties
Molecular Weight 460.5 g/mol
Molecular Formula C24H28N8O2
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass460.23352217 g/mol
Monoisotopic Mass460.23352217 g/mol
Topological Polar Surface Area130 Ų
Heavy Atom Count34
Formal Charge0
Complexity775
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Gusacitinib Manufacturers

A Gusacitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gusacitinib, including repackagers and relabelers. The FDA regulates Gusacitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gusacitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gusacitinib Suppliers

A Gusacitinib supplier is an individual or a company that provides Gusacitinib active pharmaceutical ingredient (API) or Gusacitinib finished formulations upon request. The Gusacitinib suppliers may include Gusacitinib API manufacturers, exporters, distributors and traders.

Gusacitinib GMP

Gusacitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gusacitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gusacitinib GMP manufacturer or Gusacitinib GMP API supplier for your needs.

Gusacitinib CoA

A Gusacitinib CoA (Certificate of Analysis) is a formal document that attests to Gusacitinib's compliance with Gusacitinib specifications and serves as a tool for batch-level quality control.

Gusacitinib CoA mostly includes findings from lab analyses of a specific batch. For each Gusacitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gusacitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Gusacitinib EP), Gusacitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gusacitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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