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Chemistry

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Also known as: Pentane-1,5-diamine, 1,5-diaminopentane, 462-94-2, 1,5-pentanediamine, Pentamethylenediamine, Cadaverin
Molecular Formula
C5H14N2
Molecular Weight
102.18  g/mol
InChI Key
VHRGRCVQAFMJIZ-UHFFFAOYSA-N
FDA UNII
L90BEN6OLL

Pentane-1,5-Diamine
A foul-smelling diamine formed by bacterial DECARBOXYLATION of LYSINE. It is also an intermediate secondary metabolite in lysine-derived alkaloid biosynthetic pathways (e.g., QUINOLIZIDINES and LYCOPODIUM).
1 2D Structure

Pentane-1,5-Diamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
pentane-1,5-diamine
2.1.2 InChI
InChI=1S/C5H14N2/c6-4-2-1-3-5-7/h1-7H2
2.1.3 InChI Key
VHRGRCVQAFMJIZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CCN)CCN
2.2 Other Identifiers
2.2.1 UNII
L90BEN6OLL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,5 Pentanediamine

2. 1,5-pentanediamine

3. Biodex 1

4. Pentamethylenediamine

2.3.2 Depositor-Supplied Synonyms

1. Pentane-1,5-diamine

2. 1,5-diaminopentane

3. 462-94-2

4. 1,5-pentanediamine

5. Pentamethylenediamine

6. Cadaverin

7. 1,5-pentamethylenediamine

8. Animal Coniine

9. Ai3-26937

10. Brn 1697256

11. 1,5-diamino-n-pentane

12. L90ben6oll

13. Chembl119296

14. Chebi:18127

15. N2p

16. Pentamethylenediamine Dihydrochloride

17. Einecs 207-329-0

18. Unii-l90ben6oll

19. Hsdb 7866

20. Cadaverine, 95%

21. Mfcd00008239

22. Pentane-1,5-damne

23. 1,5-diamino-pentane

24. Biodex 1-

25. 1,5-amylene Diamine

26. Cadaverine [mi]

27. 5-azaniumylpentylammonium

28. Alpha,omega-pentanediamine

29. Bmse000072

30. Ec 207-329-0

31. Schembl21367

32. 4-04-00-01310 (beilstein Handbook Reference)

33. Cadaverine, Analytical Standard

34. H2n(ch2)5nh2

35. Schembl5495920

36. Dtxsid5075448

37. Zinc1529253

38. Bbl027704

39. Bdbm50323741

40. Stl372961

41. Akos005169829

42. Am61576

43. Cadaverine, Purum, >=97.0% (gc)

44. Ccg-266036

45. Db03854

46. Ncgc00166285-01

47. As-30673

48. Db-051367

49. Ft-0600435

50. C01672

51. 462d942

52. A827022

53. Q161555

54. J-523897

55. 1948270a-6d1b-4f40-bc13-9b680ed17b17

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 102.18 g/mol
Molecular Formula C5H14N2
XLogP3-0.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass102.115698455 g/mol
Monoisotopic Mass102.115698455 g/mol
Topological Polar Surface Area52 Ų
Heavy Atom Count7
Formal Charge0
Complexity25.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

The urinary excretion of histamine, methylhistamine, putrescine, cadaverine, spermidine and spermine was examined before, during and after pregnancy in rats. During the last third of undisturbed pregnancy a distinct and steep rise occurred in the excretion of all amines studied except spermine. The peak values were found a few days before the birth of the young. In spermidine excretion a second peak was observed one or two days after delivery. Before and during the first 2 weeks of gestation on a molar basis putrescine excretion was the greatest one. During the last trimester histamine was excreted in the largest amount. Under the influence of the diamine oxidase inhibitor aminoguanidine the general pattern of excretion of diamines and polyamines in pregnant rats remained essentially unchanged but the total amount excreted increased. Most conspicuous was the great elevation of urinary contents of putrescine and cadaverine.

PMID:745086 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1281758 Andersson AC et al; J Physiol 285: 311-24 (1978)


Cadaverine has been shown to be present in the central nervous system (CNS) ... Its concentration in the whole brain varies during behavioral sleep in mammals and during hibernation in molluscs. ... Cadaverine has been considered a non-metabolite of the brain, and its presence in the body was believed to be due almost entirely to bacterial decarboxylation of lysine in the intestine. In slices of mouse brain, exogenous cadaverine accumulates against a concentration gradient and can reach a concentration ten times greater in the tissue than in the surrounding medium. The question has been therefore: does the cadaverine in the brain originate from an exogenous source; is it formed and resorbed in the intestine? Assaying cadaverine in axenic mice, /it has been/ found that this is not the case, and that there is an endogenous source of cadaverine in the mouse.

Matej S-K, Dolezalova H; Nature 252: 158-9 (1974)


4.2 Metabolism/Metabolites

It is a precursor of piperidine, which has been linked with some functional stages of the CNS. Cadaverine is the source of much of the piperidine excreted in the urine.

Matej S-K, Dolezalova H; Nature 252: 158-9 (1974)


Cadaverine ... a relatively nontoxic ptomaine, C5H14N2, formed by decarboxylation of lysine; it is sometimes one of the products of Vibrio proteus and of V. cholerae, and occasionally found in the urine in cystinuria, where it causes an unpleasant odor.

Merck Source; Resource Library Powered by Dorland's Medical Dictionary for Healthcare Consumers. Available from, as of November 19, 2010: https://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/misc/dmd-a-b-000.htm


Cadaverine is synthesized from lysine in a one-step reaction with lysine decarboxylase (LDC).

ChemEurope.com; Polyamine. In Encyclopedia of Chemistry. Available from, as of November 19, 2010: https://www.chemeurope.com/lexikon/e/Polyamine/


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Looking for 462-94-2 / Pentane-1,5-Diamine API manufacturers, exporters & distributors?

Pentane-1,5-Diamine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Pentane-1,5-Diamine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pentane-1,5-Diamine manufacturer or Pentane-1,5-Diamine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pentane-1,5-Diamine manufacturer or Pentane-1,5-Diamine supplier.

PharmaCompass also assists you with knowing the Pentane-1,5-Diamine API Price utilized in the formulation of products. Pentane-1,5-Diamine API Price is not always fixed or binding as the Pentane-1,5-Diamine Price is obtained through a variety of data sources. The Pentane-1,5-Diamine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Pentane-1,5-Diamine

Synonyms

1,5-diaminopentane, 462-94-2, 1,5-pentanediamine, Pentamethylenediamine, Cadaverin, 1,5-pentamethylenediamine

Cas Number

462-94-2

Unique Ingredient Identifier (UNII)

L90BEN6OLL

About Pentane-1,5-Diamine

A foul-smelling diamine formed by bacterial DECARBOXYLATION of LYSINE. It is also an intermediate secondary metabolite in lysine-derived alkaloid biosynthetic pathways (e.g., QUINOLIZIDINES and LYCOPODIUM).

H2N(CH2)5NH2 Manufacturers

A H2N(CH2)5NH2 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of H2N(CH2)5NH2, including repackagers and relabelers. The FDA regulates H2N(CH2)5NH2 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. H2N(CH2)5NH2 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

H2N(CH2)5NH2 Suppliers

A H2N(CH2)5NH2 supplier is an individual or a company that provides H2N(CH2)5NH2 active pharmaceutical ingredient (API) or H2N(CH2)5NH2 finished formulations upon request. The H2N(CH2)5NH2 suppliers may include H2N(CH2)5NH2 API manufacturers, exporters, distributors and traders.

H2N(CH2)5NH2 GMP

H2N(CH2)5NH2 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of H2N(CH2)5NH2 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right H2N(CH2)5NH2 GMP manufacturer or H2N(CH2)5NH2 GMP API supplier for your needs.

H2N(CH2)5NH2 CoA

A H2N(CH2)5NH2 CoA (Certificate of Analysis) is a formal document that attests to H2N(CH2)5NH2's compliance with H2N(CH2)5NH2 specifications and serves as a tool for batch-level quality control.

H2N(CH2)5NH2 CoA mostly includes findings from lab analyses of a specific batch. For each H2N(CH2)5NH2 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

H2N(CH2)5NH2 may be tested according to a variety of international standards, such as European Pharmacopoeia (H2N(CH2)5NH2 EP), H2N(CH2)5NH2 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (H2N(CH2)5NH2 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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