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Chemistry

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Also known as: 82186-71-8, Schembl2562822, Chembl1162014, Ac-30636, 7-bromo-6-chloro-3-(3-((2s,3r)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3h)-one 2-hydroxypropanoate, 7-bromo-6-chloro-3-[3-[(2s,3r)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid
Molecular Formula
C19H23BrClN3O6
Molecular Weight
504.8  g/mol
InChI Key
GATQERNJKZPJNX-LDXVYITESA-N

Halofuginone Lactate
1 2D Structure

Halofuginone Lactate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid
2.1.2 InChI
InChI=1S/C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14-,15+;/m0./s1
2.1.3 InChI Key
GATQERNJKZPJNX-LDXVYITESA-N
2.1.4 Canonical SMILES
CC(C(=O)O)O.C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
2.1.5 Isomeric SMILES
CC(C(=O)O)O.C1C[C@H]([C@@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. (+)-halofuginone

2. (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3h)-quinazolinone

3. (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3h)-quinazolinone Monohydrobromide

4. (-)-halofuginone

5. (-)-halofuginone Hydrobromide

6. 4(3h)-quinazolinone, 7-bromo-6-chloro-3-(3-((2r,3s)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, Hydrochloride (1:1), Rel-

7. 4(3h)-quinazolinone, 7-bromo-6-chloro-3-(3-((2s,3r)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, Hydrobromide (1:1)

8. 4(3h)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, Hydrobromide, Trans-(+-)-

9. 4(3h)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, Trans-, Mono(2-hydroxypropanoate)(salt)

10. 6-chloro-7-bromo-(+)-febrifugine

11. 6-chloro-7-bromofebrifugine

12. 7-bromo-6-chloro-3,3-(3-hydroxy-2-piperidyl)acetonyl-4(3h)-quinazolinone-hydrolactate

13. 7-bromo-6-chloro-3-(3-((2r,3s)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3h)-quinazolinone

14. 7-bromo-6-chloro-3-(3-((2s,3r)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3h)-quinazolinone

15. 7-bromo-6-chloro-3-(3-((2s,3r)-3-hydroxy-2-piperidyl)-2-oxo-propyl)quinazolin-4-one Hydrobromide

16. 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3h)-quinazolinone

17. 7-bromo-6-chlorofebrifugine

18. Cebegine

19. Chloro-bromofebrifugine

20. Chlorobromofebrifugine

21. Halagon

22. Halocur

23. Halofuginon

24. Halofuginone

25. Halofuginone Hbr

26. Halofuginone Hcl

27. Halofuginone Hydrobromide

28. Halofuginone Hydrobromide, (-)-

29. Halofuginone Hydrochloride

30. Halofuginone Monohydrobromide

31. Halofuginone Monohydrochloride

32. Halofuginone, (+)-

33. Halofuginone, (-)-

34. Halofunginone

35. Ru 19110

36. Ru-19110

37. Ru19110

38. Stenorol

39. Trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3h)-quinazolinone

2.2.2 Depositor-Supplied Synonyms

1. 82186-71-8

2. Schembl2562822

3. Chembl1162014

4. Ac-30636

5. 7-bromo-6-chloro-3-(3-((2s,3r)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3h)-one 2-hydroxypropanoate

6. 7-bromo-6-chloro-3-[3-[(2s,3r)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic Acid

2.3 Create Date
2007-12-12
3 Chemical and Physical Properties
Molecular Weight 504.8 g/mol
Molecular Formula C19H23BrClN3O6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass503.04588 g/mol
Monoisotopic Mass503.04588 g/mol
Topological Polar Surface Area140 Ų
Heavy Atom Count30
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

In newborn calves:

- Prevention of diarrhoea due to diagnosed Cryptosporidium parvum infection, in farms with history of cryptosporidiosis. Administration should start in the first 24 to 48 hours of age.

- Reduction of diarrhoea due to diagnosed Cryptosporidium parvum infection. Administration should start within 24 hours after the onset of diarrhoea. In both cases, the reduction of oocysts excretion has been demonstrated.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Coccidiostats

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.2 ATC Code

QP51AX08


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ABOUT THIS PAGE

Halofuginone Lactate Manufacturers

A Halofuginone Lactate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Halofuginone Lactate, including repackagers and relabelers. The FDA regulates Halofuginone Lactate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Halofuginone Lactate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Halofuginone Lactate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Halofuginone Lactate Suppliers

A Halofuginone Lactate supplier is an individual or a company that provides Halofuginone Lactate active pharmaceutical ingredient (API) or Halofuginone Lactate finished formulations upon request. The Halofuginone Lactate suppliers may include Halofuginone Lactate API manufacturers, exporters, distributors and traders.

click here to find a list of Halofuginone Lactate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Halofuginone Lactate USDMF

A Halofuginone Lactate DMF (Drug Master File) is a document detailing the whole manufacturing process of Halofuginone Lactate active pharmaceutical ingredient (API) in detail. Different forms of Halofuginone Lactate DMFs exist exist since differing nations have different regulations, such as Halofuginone Lactate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Halofuginone Lactate DMF submitted to regulatory agencies in the US is known as a USDMF. Halofuginone Lactate USDMF includes data on Halofuginone Lactate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Halofuginone Lactate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Halofuginone Lactate suppliers with USDMF on PharmaCompass.

Halofuginone Lactate GMP

Halofuginone Lactate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Halofuginone Lactate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Halofuginone Lactate GMP manufacturer or Halofuginone Lactate GMP API supplier for your needs.

Halofuginone Lactate CoA

A Halofuginone Lactate CoA (Certificate of Analysis) is a formal document that attests to Halofuginone Lactate's compliance with Halofuginone Lactate specifications and serves as a tool for batch-level quality control.

Halofuginone Lactate CoA mostly includes findings from lab analyses of a specific batch. For each Halofuginone Lactate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Halofuginone Lactate may be tested according to a variety of international standards, such as European Pharmacopoeia (Halofuginone Lactate EP), Halofuginone Lactate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Halofuginone Lactate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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