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Chemistry

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Also known as: 777-11-7, Halotex, Mycanden, Mycilan, Polik, M-1028 (meiji)
Molecular Formula
C9H4Cl3IO
Molecular Weight
361.4  g/mol
InChI Key
CTETYYAZBPJBHE-UHFFFAOYSA-N
FDA UNII
AIU7053OWL

Haloprogin
Haloprogin is an antifungal agent used as a topical cream. It was discontinued in favor of newer antifungals with fewer side effects.
1 2D Structure

Haloprogin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene
2.1.2 InChI
InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2
2.1.3 InChI Key
CTETYYAZBPJBHE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI
2.2 Other Identifiers
2.2.1 UNII
AIU7053OWL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-iodo-2-propynyl 2,4,5-trichlorophenyl Ether

2. Halotex

3. Mycilan

2.3.2 Depositor-Supplied Synonyms

1. 777-11-7

2. Halotex

3. Mycanden

4. Mycilan

5. Polik

6. M-1028 (meiji)

7. 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene

8. M 1028

9. 3-iodo-2-propynyl 2,4,5-trichlorophenyl Ether

10. 2,4,5-trichlorophenyl Iodopropargyl Ether

11. Nsc-100071

12. Ether, 3-iodo-2-propynyl 2,4,5-trichlorophenyl

13. Haloprogina

14. Haloprogine

15. Aiu7053owl

16. Chembl1289

17. Benzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)-

18. Haloprogin (200 Mg)

19. Haloproginum

20. M-1028

21. Nsc100071

22. Haloprogine [inn-french]

23. Haloproginum [inn-latin]

24. Ncgc00181134-01

25. Haloprogina [inn-spanish]

26. 1,2,4-trichloro-5-((3-iodoprop-2-yn-1-yl)oxy)benzene

27. 1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene

28. Benzene, 1,2,4-trichloro-5-[(3-iodo-2-propynyl)oxy]-

29. Halotex (tn)

30. Component Of Halotex

31. Einecs 212-286-6

32. 2,4,5-trichlorophenyl Gamma-iodopropargil Ether

33. 2,4,5-trichlorophenyl-gamma-iodopropargyl Ether

34. Unii-aiu7053owl

35. Nsc 100071

36. (3-iod-2-propinyl)-(2,4,5-trichlorphenyl)ether

37. Brn 1976771

38. Haloprogen

39. Haloprogin (jan/usan/inn)

40. Haloprogin [usan:usp:inn:jan]

41. Prestwick_232

42. Halotex (salt/mix)

43. Spectrum_001852

44. Haloprogin [mi]

45. Haloprogin [inn]

46. Haloprogin [jan]

47. Haloprogin [usan]

48. Haloprogin [vandf]

49. Ether,4,5-trichlorophenyl

50. Haloprogin [mart.]

51. Schembl3649

52. Haloprogin(200mg)

53. Dsstox_cid_26865

54. Dsstox_rid_81972

55. Haloprogin [who-dd]

56. Dsstox_gsid_46865

57. Kbioss_002369

58. 2,4,5-trichlorophenyl .gamma.-iodopropargyl Ether

59. Divk1c_000762

60. 1,2,4-trichloro-5-[(3-iodo-2-propynyl) Oxy]benzene

61. Chebi:5614

62. Benzene,1,2,4-trichloro-5-[(3-iodo-2-propynyl)oxy]

63. Dtxsid9046865

64. Haloprogin [orange Book]

65. Hms502g04

66. Kbio1_000762

67. Kbio2_002365

68. Kbio2_004933

69. Kbio2_007501

70. Wln: I1uu2or Bg Dg Eg

71. Ninds_000762

72. Hms3713a06

73. Bcp20218

74. Zinc1530649

75. Tox21_112741

76. Bdbm50194601

77. Ccg-220402

78. Db00793

79. 2,5-trichlorophenyl Iodopropargyl Ether

80. Idi1_000762

81. Ncgc00181134-02

82. Ncgc00181134-04

83. Cas-777-11-7

84. Hy-16246

85. Cs-0006262

86. 3-iodo-2-propynyl 2,5-trichlorophenyl Ether

87. D00339

88. 2,5-trichlorophenyl .gamma.-iodopropargil Ether

89. 2,5-trichlorophenyl .gamma.-iodopropargyl Ether

90. 777h117

91. 1,2,4-trichloro-5-(3-iodoprop-2-ynyloxy)benzene

92. Q5643439

93. 1,2,4-trichloro-5-(3-iodo-prop-2-ynyloxy)-benzene

94. Benzene,2,4-trichloro-5-[(3-iodo-2-propynyl)oxy]-

95. Brd-k13238168-001-01-2

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 361.4 g/mol
Molecular Formula C9H4Cl3IO
XLogP34.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass359.83725 g/mol
Monoisotopic Mass359.83725 g/mol
Topological Polar Surface Area9.2 Ų
Heavy Atom Count14
Formal Charge0
Complexity247
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).


5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.3 ATC Code

D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AE - Other antifungals for topical use

D01AE11 - Haloprogin


5.4 Mechanism of Action

Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals.


ABOUT THIS PAGE

Looking for 777-11-7 / Haloprogin API manufacturers, exporters & distributors?

Haloprogin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Haloprogin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Haloprogin manufacturer or Haloprogin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Haloprogin manufacturer or Haloprogin supplier.

PharmaCompass also assists you with knowing the Haloprogin API Price utilized in the formulation of products. Haloprogin API Price is not always fixed or binding as the Haloprogin Price is obtained through a variety of data sources. The Haloprogin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Haloprogin

Synonyms

777-11-7, Halotex, Mycanden, Mycilan, Polik, M-1028 (meiji)

Cas Number

777-11-7

Unique Ingredient Identifier (UNII)

AIU7053OWL

About Haloprogin

Haloprogin is an antifungal agent used as a topical cream. It was discontinued in favor of newer antifungals with fewer side effects.

Haloprogin Manufacturers

A Haloprogin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Haloprogin, including repackagers and relabelers. The FDA regulates Haloprogin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Haloprogin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Haloprogin Suppliers

A Haloprogin supplier is an individual or a company that provides Haloprogin active pharmaceutical ingredient (API) or Haloprogin finished formulations upon request. The Haloprogin suppliers may include Haloprogin API manufacturers, exporters, distributors and traders.

Haloprogin GMP

Haloprogin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Haloprogin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Haloprogin GMP manufacturer or Haloprogin GMP API supplier for your needs.

Haloprogin CoA

A Haloprogin CoA (Certificate of Analysis) is a formal document that attests to Haloprogin's compliance with Haloprogin specifications and serves as a tool for batch-level quality control.

Haloprogin CoA mostly includes findings from lab analyses of a specific batch. For each Haloprogin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Haloprogin may be tested according to a variety of international standards, such as European Pharmacopoeia (Haloprogin EP), Haloprogin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Haloprogin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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