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Chemistry

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Also known as: 19210-12-9, E-harpagoside, 8kgs1dc5zu, Chebi:5625, [(1s,4as,5r,7s,7as)-4a,5-dihydroxy-7-methyl-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (e)-3-phenylprop-2-enoate, Smr001233395
Molecular Formula
C24H30O11
Molecular Weight
494.5  g/mol
InChI Key
KVRQGMOSZKPBNS-FMHLWDFHSA-N
FDA UNII
8KGS1DC5ZU

Harpagoside
harpagoside is a natural product found in Verbascum lychnitis, Verbascum sinuatum, and other organisms with data available.
1 2D Structure

Harpagoside

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate
2.1.2 InChI
InChI=1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1
2.1.3 InChI Key
KVRQGMOSZKPBNS-FMHLWDFHSA-N
2.1.4 Canonical SMILES
CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4
2.1.5 Isomeric SMILES
C[C@@]1(C[C@H]([C@]2([C@@H]1[C@@H](OC=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O)OC(=O)/C=C/C4=CC=CC=C4
2.2 Other Identifiers
2.2.1 UNII
8KGS1DC5ZU
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Harpagophytum Extract Ws 1531

2. Harpagoside-b

3. Ws 1531

4. Ws1531

2.3.2 Depositor-Supplied Synonyms

1. 19210-12-9

2. E-harpagoside

3. 8kgs1dc5zu

4. Chebi:5625

5. [(1s,4as,5r,7s,7as)-4a,5-dihydroxy-7-methyl-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (e)-3-phenylprop-2-enoate

6. Smr001233395

7. Unii-8kgs1dc5zu

8. Harpaside

9. Einecs 242-881-6

10. Prestwick3_000988

11. Harpagoside [inci]

12. Bspbio_001055

13. Harpagoside [who-dd]

14. Mls002154086

15. Mls002473324

16. Schembl893387

17. Bpbio1_001161

18. Chembl516702

19. Megxp0_000469

20. Harpagoside, Analytical Standard

21. Acon0_000056

22. Acon1_000134

23. Dtxsid101032528

24. Hms2098e17

25. Hms2231n12

26. Hy-n0396

27. Zinc8214398

28. Mfcd00017415

29. S9171

30. Akos015896715

31. Ccg-269650

32. Lmpr0102070010

33. Ncgc00179325-01

34. Ncgc00179325-02

35. Ncgc00179325-04

36. Ac-34268

37. As-56071

38. Ab00513986

39. Cs-0008931

40. C09783

41. H10494

42. 210h129

43. A880338

44. Q-100231

45. Brd-k07996107-001-01-7

46. Brd-k07996107-001-03-3

47. Harpagoside, Primary Pharmaceutical Reference Standard

48. Q25099323

49. Harpagoside, European Pharmacopoeia (ep) Reference Standard

50. (1s,4as,5r,7s,7as)-4a,5-dihydroxy-7-methyl-1-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl Cinnamate

51. (1s,4as,5r,7s,7as)-4a,5-dihydroxy-7-methyl-1-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl Cinnamate

52. (1s-(1alpha,4aalpha,5alpha,7alpha(e),7aalpha))-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-d-glucopyranoside

53. .beta.-d-glucopyranoside, (1s,4as,5r,7s,7as)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-(((2e)-1-oxo-3-phenyl-2-propenyl)oxy)cyclopenta(c)pyran-1-yl

54. Ncgc00179325-04_c24h30o11_(1s,4as,5r,7s,7as)-1-(beta-d-glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl (2e)-3-phenylacrylate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 494.5 g/mol
Molecular Formula C24H30O11
XLogP3-0.6
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass494.17881177 g/mol
Monoisotopic Mass494.17881177 g/mol
Topological Polar Surface Area175 Ų
Heavy Atom Count35
Formal Charge0
Complexity811
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Harpagoside Manufacturers

A Harpagoside manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Harpagoside, including repackagers and relabelers. The FDA regulates Harpagoside manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Harpagoside API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Harpagoside Suppliers

A Harpagoside supplier is an individual or a company that provides Harpagoside active pharmaceutical ingredient (API) or Harpagoside finished formulations upon request. The Harpagoside suppliers may include Harpagoside API manufacturers, exporters, distributors and traders.

click here to find a list of Harpagoside suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Harpagoside CEP

A Harpagoside CEP of the European Pharmacopoeia monograph is often referred to as a Harpagoside Certificate of Suitability (COS). The purpose of a Harpagoside CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Harpagoside EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Harpagoside to their clients by showing that a Harpagoside CEP has been issued for it. The manufacturer submits a Harpagoside CEP (COS) as part of the market authorization procedure, and it takes on the role of a Harpagoside CEP holder for the record. Additionally, the data presented in the Harpagoside CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Harpagoside DMF.

A Harpagoside CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Harpagoside CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Harpagoside suppliers with CEP (COS) on PharmaCompass.

Harpagoside GMP

Harpagoside Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Harpagoside GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Harpagoside GMP manufacturer or Harpagoside GMP API supplier for your needs.

Harpagoside CoA

A Harpagoside CoA (Certificate of Analysis) is a formal document that attests to Harpagoside's compliance with Harpagoside specifications and serves as a tool for batch-level quality control.

Harpagoside CoA mostly includes findings from lab analyses of a specific batch. For each Harpagoside CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Harpagoside may be tested according to a variety of international standards, such as European Pharmacopoeia (Harpagoside EP), Harpagoside JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Harpagoside USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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