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Hematoporphyrins

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF

2 API Suppliers
2 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Haematoporphyrin, 14459-29-1, Hematoporphyrin ix, Photodyn, Hematoporphyrin i, Hemoporfin

Molecular Formula

C₃₄H₃₈N₄O₆

Molecular Weight

598.7 g/mol

InChI Key

KFKRXESVMDBTNQ-UHFFFAOYSA-N

FDA UNII

HBT6M5H379

Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.

1 2D Structure

Hematoporphyrins

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[18-(2-carboxyethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid

2.1.2 InChI

InChI=1S/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,37-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)

2.1.3 InChI Key

KFKRXESVMDBTNQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4CCC(=O)O)C)C(=C3C)CCC(=O)O)C(C)O

2.2 Other Identifiers

2.2.1 UNII

HBT6M5H379

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Haematoporphyrin Ix

2. Hematoporphyrins

3. Hemedonin

2.3.2 Depositor-Supplied Synonyms

1. Haematoporphyrin

2. 14459-29-1

3. Hematoporphyrin Ix

4. Photodyn

5. Hematoporphyrin I

6. Hemoporfin

7. Nsc 59265

8. Nsc59265

9. 21h,23h-porphine-2,18-dipropanoic Acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

10. Nsc-59265

11. 3-[18-(2-carboxyethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic Acid

12. Hp

13. Nsc 267084

14. Nsc-267084

15. 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-dipropanoic Acid

16. Hbt6m5h379

17. Chebi:36162

18. Hematoporphyrin_i

19. 2,18-porphinedipropionic Acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

20. 2,4-bis(1-hydroxyethyl)-1,3,5,8-tetramethyl-5,7-porphindipropionsaeure

21. 1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionic Acid

22. 7,12-bis(1-hydroxyethyl)-2,8,13,17-tetramethyl-21h,23h-porphin-2,18-dipropionsaeure

23. Hematoporphyrins

24. 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionic Acid

25. 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-dipropanoic Acid

26. Hp (van)

27. 2, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

28. Hamatoporphyrin

29. Photosan 3

30. 1,5,8-tetramethyl-2,4-bis(.alpha.-hydroxyethyl)prophine-6,7-dipropionic Acid

31. 21h,18-dipropanoic Acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

32. Wln: T D5 I5 N5-16-5 A D- I- N- Am D-n I-m N-nj Eyq F J K2vq O2vq Tyq U

33. Hpix

34. Einecs 238-450-7

35. Mfcd00005077

36. Haemaporphyrin

37. Brn 0078957

38. Spectrum_001204

39. Spectrum2_000436

40. Spectrum3_001110

41. Spectrum4_001942

42. Spectrum5_000763

43. Hematoporphyrin [mi]

44. Hemoporfin [who-dd]

45. Unii-hbt6m5h379

46. Schembl15669

47. Schembl15670

48. Bspbio_002820

49. Kbiogr_002346

50. Kbioss_001684

51. Spbio_000452

52. Chembl317840

53. Chembl403729

54. Schembl1649168

55. Hematoporphyrin [who-dd]

56. Kbio2_001684

57. Kbio2_004252

58. Kbio2_006820

59. Kbio3_002040

60. Dtxsid00864508

61. Dtxsid901030645

62. Hy-b0754

63. Nsc267084

64. Ccg-214649

65. Sdccgmls-0066934.p001

66. 2,18-porphinedipropionic Acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (van)

67. Ncgc00185009-01

68. Ncgc00185009-02

69. As-78345

70. Hematoporphyrin Base Cas 14459-29-1

71. Ft-0626879

72. A808241

73. Sr-05000002762

74. J-007971

75. Sr-05000002762-1

76. 1,3,5,8-tetramethyl-2,4-bis( -hydroxyethyl)porphine-6,7-dipropionate

77. 1,3,5,8-tetramethyl-2,4-bis( -hydroxyethyl)porphine-6,7-dipropionic Acid

78. 1,3,5,8-tetramethyl-2,4-bis(a-hydroxyethyl)porphine-6,7-dipropionate

79. 1,3,5,8-tetramethyl-2,4-bis(a-hydroxyethyl)porphine-6,7-dipropionic Acid

80. 1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionate

81. 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionate

82. 1,3,5,8-tetramethyl-2,4-bis(.alpha.-hydroxyethyl)prophine-6,7-dipropionic Acid

83. 3,3'-[7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic Acid

84. 8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21h,23h-porphyrin-2,18-dipropionic Acid

85. 136752-88-0

86. 21h,23h-porphine-2,18-dipropanoic Acid, 7(or 12)-(1-hydroxyethyl)-12(or 7)-(1-methoxyethyl)-3,8,13,17-tetramethyl-

87. 3-[(1z,4z,9z,15z)-18-(2-carboxyethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21,23-dihydroporphyrin-2-yl]propanoic Acid

88. Photodyn And 8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21h,23h-porphine-2,18-dipropionic Acid

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₃₈N₄O₆
Molecular Weight	598.7 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	598.27913494 g/mol
Monoisotopic Mass	598.27913494 g/mol
Topological Polar Surface Area	172 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	1020
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Photosensitizing Agents

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)

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ABOUT THIS PAGE

Hematoporphyrins Manufacturers

A Hematoporphyrins manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hematoporphyrins, including repackagers and relabelers. The FDA regulates Hematoporphyrins manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hematoporphyrins API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Hematoporphyrins Suppliers

A Hematoporphyrins supplier is an individual or a company that provides Hematoporphyrins active pharmaceutical ingredient (API) or Hematoporphyrins finished formulations upon request. The Hematoporphyrins suppliers may include Hematoporphyrins API manufacturers, exporters, distributors and traders.

click here to find a list of Hematoporphyrins suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hematoporphyrins USDMF

A Hematoporphyrins DMF (Drug Master File) is a document detailing the whole manufacturing process of Hematoporphyrins active pharmaceutical ingredient (API) in detail. Different forms of Hematoporphyrins DMFs exist exist since differing nations have different regulations, such as Hematoporphyrins USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hematoporphyrins DMF submitted to regulatory agencies in the US is known as a USDMF. Hematoporphyrins USDMF includes data on Hematoporphyrins's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hematoporphyrins USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hematoporphyrins suppliers with USDMF on PharmaCompass.

Hematoporphyrins GMP

Hematoporphyrins Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hematoporphyrins GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hematoporphyrins GMP manufacturer or Hematoporphyrins GMP API supplier for your needs.

Hematoporphyrins CoA

A Hematoporphyrins CoA (Certificate of Analysis) is a formal document that attests to Hematoporphyrins's compliance with Hematoporphyrins specifications and serves as a tool for batch-level quality control.

Hematoporphyrins CoA mostly includes findings from lab analyses of a specific batch. For each Hematoporphyrins CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hematoporphyrins may be tested according to a variety of international standards, such as European Pharmacopoeia (Hematoporphyrins EP), Hematoporphyrins JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hematoporphyrins USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.