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Chemistry

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Also known as: Hepes, 7365-45-9, 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonic acid, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid, 1-piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-
Molecular Formula
C8H18N2O4S
Molecular Weight
238.31  g/mol
InChI Key
JKMHFZQWWAIEOD-UHFFFAOYSA-N
FDA UNII
RWW266YE9I

Hepes API
A dipolar ionic buffer.
1 2D Structure

Hepes API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
2.1.2 InChI
InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
2.1.3 InChI Key
JKMHFZQWWAIEOD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCO)CCS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
RWW266YE9I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hepes

2. Hepes Monosodium Salt

3. Monosodium Salt, Hepes

4. N 2 Hydroxyethylpiperazine N' 2' Ethanesulfonic Acid

5. N-2-hydroxyethylpiperazine-n'-2'-ethanesulfonic Acid

6. Salt, Hepes Monosodium

2.3.2 Depositor-Supplied Synonyms

1. Hepes

2. 7365-45-9

3. 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonic Acid

4. 4-(2-hydroxyethyl)-1-piperazineethanesulfonic Acid

5. 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic Acid

6. 1-piperazineethanesulfonic Acid, 4-(2-hydroxyethyl)-

7. 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic Acid

8. 4-(2-hydroxyethyl)-1-piperazineethane Sulfonic Acid

9. Chebi:42334

10. Hydroxyethylpiperazine Ethane Sulfonic Acid

11. N-2-hydroxyethylpiperazine-n'-ethanesulfonate

12. Mfcd00006158

13. N-2-hydroxyethylpiperazine-n'-ethanesulfonic Acid

14. N-2-hydroxyethylpiperazine-n-ethane Sulfonic Acid

15. Nsc 166663

16. Rww266ye9i

17. 4-(2-hydroxyethyl)piperazin-1-ylethanesulphonic Acid

18. N-2-hydroxyethylpiperazine N',2'-ethanesulfonic Acid

19. Nsc-166663

20. 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic Acid

21. N-(2-hydroxyethyl)piperazine-n'-(2-ethanesulfonic Acid)

22. Tvz 7;was 13;nsc 166663

23. Brn 0883043

24. 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethane-1-sulfonic Acid

25. Monosodium Salt, Hepes

26. Hepes Monosodium Salt

27. Salt, Hepes Monosodium

28. Unii-rww266ye9i

29. Hepes Buffer

30. Hebes

31. Hepes, Pharmagrade, Manufactured Under Appropriate Controls For Use As A Raw Material In Pharma Or Biopharmaceutical Production, Suitable For Cell Culture

32. Prestwick_256

33. Einecs 230-907-9

34. Hepes, Dry Powder

35. Hepes Buffered Saline

36. 1d1p

37. 1dg9

38. Hepes, Biochemical Grade

39. 15(r)-hydroperoxy-epe

40. Hepes [mi]

41. Hepes, 99.5%

42. Epitope Id:190604

43. Ec 230-907-9

44. 5-23-02-00379 (beilstein Handbook Reference)

45. (4-(2-hydroxyethyl)-1-piperazineethanesulfonic Acid

46. Hepes Buffer Solution (1m)

47. N-2-hydroxyethylpiperazine-n'-2-ethanesulfonic Acid

48. N 2 Hydroxyethylpiperazine N' 2' Ethanesulfonic Acid

49. N-2-hydroxyethylpiperazine-n'-2'-ethanesulfonic Acid

50. 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonicacid

51. Chembl1232545

52. Dtxsid5040382

53. 2-[4-(2-hydroxyethyl)-1-piperazinyl] Ethanesulfonic Acid

54. Hepes, Nist Srm 2181

55. Amy23345

56. Bcp06984

57. Hepes, >=99.5% (titration)

58. Hy-d0857

59. Hepes, >=99.0%

60. Nsc166663

61. S6831

62. Stk033062

63. Zinc19203136

64. Hepes Buffer Solution, 1 M In H2o

65. Akos001696205

66. Hepes, >=99.0% (t)

67. Hepes-buffered Saline, Ph 6.5 (5x)

68. Hepes-buffered Saline, Ph 7.0 (5x)

69. Bs-17486

70. Hepes, 0.5m Buffer Solution, Ph 6.5

71. Hepes, 0.5m Buffer Solution, Ph 7.5

72. Hepes, 0.5m Buffer Solution, Ph 7.6

73. Hepes, 0.5m Buffer Solution, Ph 8.5

74. Hepes, 0.5m Buffer Solution, Ph 9.0

75. Hepes, 1.0m Buffer Solution, Ph 6.5

76. Hepes, 1.0m Buffer Solution, Ph 7.0

77. Hepes, 1.0m Buffer Solution, Ph 7.5

78. Hepes, 1.0m Buffer Solution, Ph 8.0

79. Hepes, 1.0m Buffer Solution, Ph 8.5

80. Ds-015636

81. Hepes, Vetec(tm) Reagent Grade, 99.5%

82. 6,11-dibromo-1,4-dioxaspiro[4.7]undecane

83. B7302

84. Cs-0015167

85. Ft-0629149

86. Ft-0767998

87. H0396

88. F20297

89. 4-(2-hydroxyethyl)-1-piperazine Ethanesulfonate

90. 4-(2-hydroxyethyl)-1-piperazineethane Sulfonate

91. 4-(2-hydroxyethyl)-1-piperazine Ethanesulphonate

92. 4-(2-hydroxyethyl)-1-piperazineethane Sulphonate

93. A837886

94. N-2-hydroxyethylpiperazine-n-2-ethanesulfonic Acid

95. Q418359

96. 4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic Acid

97. 4-(2-hydroxylethyl)piperazine-1-ethanesulfonic Acid

98. J-521424

99. N-2 Hydroxyethylpiperazine-n-2-ethane-sulfonic Acid

100. N-2-hydroxyethylpiperazino-n'-2-ethanesulfonic Acid

101. 4-(2-hydroxyethyl)-1-piperazine Ethanesulphonic Acid

102. 4-(2-hydroxyethyl)-1-piperazineethane Sulphonic Acid

103. Hepes-buffered Saline, Ph 7.0 (2x For Transfection)

104. N-(2-hydroxyethyl)-piperazine-n'-ethanesulfonic Acid

105. 4-(2-hydroxyethyl)piperazine-1-(2-ethanesulfonic Acid)

106. F0001-1858

107. Hepes, Bioultra, For Molecular Biology, >=99.5% (t)

108. Hepes,4-(2-hydroxyethyl)-1-piperazineethanesulfonic Acid

109. Hydroxyethylpiperazine Ethane Sulfonic Acid [ii]

110. Hydroxyethylpiperazine Ethane Sulfonic Acid [inci]

111. 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethane Sulfonic Acid

112. 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic Acid #

113. Hepes (4-(2-hydroxyethyl)-1-piperazineethanesulfonic Acid)

114. Hepes, Anhydrous, Free-flowing, Redi-dri(tm), >=99.5%

115. N-2-hydroxyethylpiperazine N'-2'-ethanesulphonic Acid

116. Hepes Buffered Saline, Bioultra, For Molecular Biology, 2x Concentrate

117. Hepes, Bioperformance Certified, >=99.5% (titration), Cell Culture Tested

118. Hepes, Bioxtra, Ph 5.0-6.5 (1 M In H2o), >=99.5% (titration)

119. Hepes, Pharmaceutical Secondary Standard; Certified Reference Material

120. Hepes Solution, 1 M, Ph 7.0-7.6, Sterile-filtered, Bioreagent, Suitable For Cell Culture

121. Hepes Solution, Bioperformance Certified, 1 M, Suitable For Cell Culture, 0.2 Mum Filtered

122. Hepes, Bioxtra, Suitable For Mouse Embryo Cell Culture, >=99.5% (titration)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 238.31 g/mol
Molecular Formula C8H18N2O4S
XLogP3-4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass238.09872823 g/mol
Monoisotopic Mass238.09872823 g/mol
Topological Polar Surface Area89.5 Ų
Heavy Atom Count15
Formal Charge0
Complexity267
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Buffers

A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)


ABOUT THIS PAGE

Hepes API Manufacturers

A Hepes API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hepes API, including repackagers and relabelers. The FDA regulates Hepes API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hepes API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Hepes API Suppliers

A Hepes API supplier is an individual or a company that provides Hepes API active pharmaceutical ingredient (API) or Hepes API finished formulations upon request. The Hepes API suppliers may include Hepes API API manufacturers, exporters, distributors and traders.

click here to find a list of Hepes API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hepes API USDMF

A Hepes API DMF (Drug Master File) is a document detailing the whole manufacturing process of Hepes API active pharmaceutical ingredient (API) in detail. Different forms of Hepes API DMFs exist exist since differing nations have different regulations, such as Hepes API USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hepes API DMF submitted to regulatory agencies in the US is known as a USDMF. Hepes API USDMF includes data on Hepes API's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hepes API USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hepes API suppliers with USDMF on PharmaCompass.

Hepes API GMP

Hepes API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hepes API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hepes API GMP manufacturer or Hepes API GMP API supplier for your needs.

Hepes API CoA

A Hepes API CoA (Certificate of Analysis) is a formal document that attests to Hepes API's compliance with Hepes API specifications and serves as a tool for batch-level quality control.

Hepes API CoA mostly includes findings from lab analyses of a specific batch. For each Hepes API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hepes API may be tested according to a variety of international standards, such as European Pharmacopoeia (Hepes API EP), Hepes API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hepes API USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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