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Chemistry

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Also known as: Gynipral, Bronalin, Etoscol, 32266-10-7, Leanol, 30117-45-4
Molecular Formula
C22H34N2O10S
Molecular Weight
518.6  g/mol
InChI Key
GTDCHGNGVGRHQY-UHFFFAOYSA-N
FDA UNII
U851S9102C

Hexoprenaline
Stimulant of adrenergic beta 2 receptors. It is used as a bronchodilator, antiasthmatic agent, and tocolytic agent.
1 2D Structure

Hexoprenaline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-[6-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexylamino]-1-hydroxyethyl]benzene-1,2-diol;sulfuric acid
2.1.2 InChI
InChI=1S/C22H32N2O6.H2O4S/c25-17-7-5-15(11-19(17)27)21(29)13-23-9-3-1-2-4-10-24-14-22(30)16-6-8-18(26)20(28)12-16;1-5(2,3)4/h5-8,11-12,21-30H,1-4,9-10,13-14H2;(H2,1,2,3,4)
2.1.3 InChI Key
GTDCHGNGVGRHQY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1C(CNCCCCCCNCC(C2=CC(=C(C=C2)O)O)O)O)O)O.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
U851S9102C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ginipral

2. Gynipral

3. Hexoprenaline

4. Ipradol

5. St 1512

6. St-1512

7. St1512

8. Sulfate, Hexoprenaline

2.3.2 Depositor-Supplied Synonyms

1. Gynipral

2. Bronalin

3. Etoscol

4. 32266-10-7

5. Leanol

6. 30117-45-4

7. Delaprem

8. Hexoprenaline Sulphate

9. Nsc-292266

10. St1512/so4

11. 4,4'-[hexane-1,6-diylbis[imino(1-hydroxyethylene)]]dipyrocatechol Sulphate

12. Dsstox_cid_26688

13. Dsstox_rid_81822

14. Dsstox_gsid_46688

15. Hexoprenaline Sulfate (usan)

16. Hexoprenalinesulphate

17. Hexoprenaline Sulfate [usan]

18. 4,4'-(hexane-1,6-diylbis(imino(1-hydroxyethylene)))dipyrocatechol Sulphate

19. 4-[2-[6-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexylamino]-1-hydroxyethyl]benzene-1,2-diol;sulfuric Acid

20. Cas-32266-10-7

21. U851s9102c

22. Ncgc00167522-01

23. Delaprem (tn)

24. Einecs 250-057-2

25. 1,2-benzenediol, 4,4'-(1,6-hexanediylbis(imino(1-hydroxy-2,1-ethanediyl)))bis-, Sulfate (1:1) (salt)

26. Schembl598186

27. Chembl2104813

28. Dtxsid6046688

29. Chebi:31670

30. Hexoprenaline Sulfate [mi]

31. Hexoprenaline Sulfate [jan]

32. St-1512/so4

33. Tox21_112519

34. Nsc292266

35. Hexoprenaline Sulfate [mart.]

36. Hexoprenaline Sulfate [who-dd]

37. Tox21_112519_1

38. Ncgc00167522-02

39. D02396

40. Q27290818

41. 1, 4,4'-[1,6-hexanediylbis[imino(1-hydroxy-2,1-ethanediyl)]]bis-, Sulfate (1:1) (salt)

42. (+/-)-.alpha.,.alpha.'-(hexamethylenebis(iminomethylene))bis(3,4-dihydroxybenzyl Alcohol) Sulfate (1:1) (salt)

43. (+/-)-.alpha.,.alpha.'-(hexamethylenebis(iminomethylene))bis(3,4-dihydroxybenzyl Alcohol) Sulphate (1:1) (salt)

44. 1,2-benzenediol, 4,4'-(1,6-hexanediylbis(imino(1-hydroxy-2,1-ethanediyl)))bis-, Sulphate (1:1) (salt)

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 518.6 g/mol
Molecular Formula C22H34N2O10S
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count12
Rotatable Bond Count13
Exact Mass518.19341646 g/mol
Monoisotopic Mass518.19341646 g/mol
Topological Polar Surface Area228 Ų
Heavy Atom Count35
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


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ABOUT THIS PAGE

Hexoprenaline Manufacturers

A Hexoprenaline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hexoprenaline, including repackagers and relabelers. The FDA regulates Hexoprenaline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hexoprenaline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hexoprenaline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hexoprenaline Suppliers

A Hexoprenaline supplier is an individual or a company that provides Hexoprenaline active pharmaceutical ingredient (API) or Hexoprenaline finished formulations upon request. The Hexoprenaline suppliers may include Hexoprenaline API manufacturers, exporters, distributors and traders.

click here to find a list of Hexoprenaline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hexoprenaline USDMF

A Hexoprenaline DMF (Drug Master File) is a document detailing the whole manufacturing process of Hexoprenaline active pharmaceutical ingredient (API) in detail. Different forms of Hexoprenaline DMFs exist exist since differing nations have different regulations, such as Hexoprenaline USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hexoprenaline DMF submitted to regulatory agencies in the US is known as a USDMF. Hexoprenaline USDMF includes data on Hexoprenaline's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hexoprenaline USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hexoprenaline suppliers with USDMF on PharmaCompass.

Hexoprenaline GMP

Hexoprenaline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hexoprenaline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hexoprenaline GMP manufacturer or Hexoprenaline GMP API supplier for your needs.

Hexoprenaline CoA

A Hexoprenaline CoA (Certificate of Analysis) is a formal document that attests to Hexoprenaline's compliance with Hexoprenaline specifications and serves as a tool for batch-level quality control.

Hexoprenaline CoA mostly includes findings from lab analyses of a specific batch. For each Hexoprenaline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hexoprenaline may be tested according to a variety of international standards, such as European Pharmacopoeia (Hexoprenaline EP), Hexoprenaline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hexoprenaline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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