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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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Chemistry

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Also known as: Beta-thujaplicin, 499-44-5, 4-isopropyltropolone, Hinokitol, Beta-thujaplicine, Isopropyltropolone
Molecular Formula
C10H12O2
Molecular Weight
164.20  g/mol
InChI Key
FUWUEFKEXZQKKA-UHFFFAOYSA-N
FDA UNII
U5335D6EBI

Hinokitiol
hinokitiol is a natural product found in Chamaecyparis obtusa, Thujopsis dolabrata, and other organisms with data available.
1 2D Structure

Hinokitiol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
2.1.2 InChI
InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
2.1.3 InChI Key
FUWUEFKEXZQKKA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)C1=CC(=O)C(=CC=C1)O
2.2 Other Identifiers
2.2.1 UNII
U5335D6EBI
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-hydroxy-4-isopropyl- 2,4,6-cycloheptatriene-1-one

2. 4-isopropyltropolone

3. Beta-thujaplicin

4. Beta-thujaplicin, Sodium Salt

2.3.2 Depositor-Supplied Synonyms

1. Beta-thujaplicin

2. 499-44-5

3. 4-isopropyltropolone

4. Hinokitol

5. Beta-thujaplicine

6. Isopropyltropolone

7. Thujaplicin, Beta

8. Tropolone, 4-isopropyl-

9. .beta.-thujaplicin

10. 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one

11. Beta-isopropyltropolon

12. 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-

13. Beta-isopropyltropolone

14. .beta.-isopropyltropolon

15. B-thujaplicin

16. 2-hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one

17. Nsc 18804

18. .beta.-thujaplicine

19. 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one

20. Nsc18804

21. 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

22. 2-hydroxy-4-isopropyl-2,4,6-cyclohepta-2,4,6-trien-1-one

23. Chembl48310

24. Mls001048906

25. 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one

26. Hinokitiol 4-isopropyltropolone

27. U5335d6ebi

28. Chebi:10447

29. Nsc-18804

30. Smr000387099

31. 2,4,6-cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-

32. Einecs 207-880-7

33. Brn 2045206

34. Unii-u5335d6ebi

35. Ss-thujaplicine

36. Ai3-28398

37. Beta -thujaplicin

38. Beta -thujaplicine

39. 6-isopropyl-tropolon

40. Thujaplicin, .beta.

41. 2-hydroxy-4-isopropyl- 2,4,6-cycloheptatriene-1-one

42. 4-isopropyl-tropolone

43. Beta -isopropyltropolon

44. Beta-thujaplicin, 99%

45. 4(6)-isopropyltropolone

46. Hinokitiol [inci]

47. Ncimech_000141

48. Cid_3611

49. Hinokitiol [who-dd]

50. Bspbio_001025

51. Kbiogr_000365

52. Kbioss_000365

53. 4-08-00-00488 (beilstein Handbook Reference)

54. Bidd:er0491

55. Schembl158795

56. Spectrum1505160

57. 2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one

58. Dtxsid6043911

59. Bdbm79632

60. Fuwuefkexzqkka-uhfffaoysa-

61. Kbio2_000365

62. Kbio2_002933

63. Kbio2_005501

64. Kbio3_000709

65. Kbio3_000710

66. Wln: L7vj Bq Dy1&1

67. .beta.-thujaplicin [mi]

68. Amy3994

69. Bio2_000343

70. Bio2_000823

71. Hms1362c07

72. Hms1792c07

73. Hms1990c07

74. Hms2269d23

75. Hms3403c07

76. Hy-b2230

77. Bbl036671

78. Bdbm50330794

79. Ccg-35378

80. Mfcd00040180

81. S4771

82. Stl559050

83. Zinc95911093

84. Akos015895184

85. Akos037515521

86. Cs-7724

87. Ks-5297

88. Idi1_002098

89. Qtl1_000044

90. Ncgc00094565-01

91. Ncgc00094565-02

92. Ncgc00094565-03

93. Ncgc00094565-04

94. Ncgc00094565-05

95. Ncgc00179338-01

96. Nci60_001565

97. Db-051705

98. Ft-0603426

99. H0142

100. C09904

101. C75327

102. D04876

103. Beta-thujaplicin, Saj Special Grade, >=99.0%

104. 2-hydroxy-4-isopropyl-2,6-cycloheptatrien-1-one

105. 2-hydroxy-4-isopropyl-cyclohepta-2,4,6-trienone

106. 2-hydroxy-6-isopropyl-2,4,6-cycloheptene-1-one

107. 499h445

108. A923788

109. Sr-01000737397

110. 2,6-cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-

111. 2-hydroxy-4-isopropyl-cyclohepta2,4,6-trien-1-one

112. J-521461

113. Q2705171

114. Sr-01000737397-2

115. 2-hydroxy-4-isopropyl-2,4, 6-cycloheptatrien-1-one

116. 2-hydroxy-4-isopropyl-cyclohepta-2,4,6-trien-1-one

117. Brd-k37691127-001-02-2

118. 2-hydroxy-6-propan-2-yl-1-cyclohepta-2,4,6-trienone

119. 2-oxidanyl-6-propan-2-yl-cyclohepta-2,4,6-trien-1-one

120. Z2671848059

121. 2,6-cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-

122. (2e,4z,6z)-2-hydroxy-4-isopropylcyclohepta-2,4,6-trienone

123. 2-hydroxy-4(6)-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, 9ci

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 164.20 g/mol
Molecular Formula C10H12O2
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass164.083729621 g/mol
Monoisotopic Mass164.083729621 g/mol
Topological Polar Surface Area37.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity280
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Infective Agents

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)


Iron Chelating Agents

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems. (See all compounds classified as Iron Chelating Agents.)


Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)


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ABOUT THIS PAGE

Hinokitiol Manufacturers

A Hinokitiol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hinokitiol, including repackagers and relabelers. The FDA regulates Hinokitiol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hinokitiol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hinokitiol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hinokitiol Suppliers

A Hinokitiol supplier is an individual or a company that provides Hinokitiol active pharmaceutical ingredient (API) or Hinokitiol finished formulations upon request. The Hinokitiol suppliers may include Hinokitiol API manufacturers, exporters, distributors and traders.

click here to find a list of Hinokitiol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hinokitiol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Hinokitiol Drug Master File in Japan (Hinokitiol JDMF) empowers Hinokitiol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Hinokitiol JDMF during the approval evaluation for pharmaceutical products. At the time of Hinokitiol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Hinokitiol suppliers with JDMF on PharmaCompass.

Hinokitiol GMP

Hinokitiol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hinokitiol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hinokitiol GMP manufacturer or Hinokitiol GMP API supplier for your needs.

Hinokitiol CoA

A Hinokitiol CoA (Certificate of Analysis) is a formal document that attests to Hinokitiol's compliance with Hinokitiol specifications and serves as a tool for batch-level quality control.

Hinokitiol CoA mostly includes findings from lab analyses of a specific batch. For each Hinokitiol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hinokitiol may be tested according to a variety of international standards, such as European Pharmacopoeia (Hinokitiol EP), Hinokitiol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hinokitiol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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