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    Chemistry

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    Also known as: 56-92-8, Histamine 2hcl, Ceplene, Peremin, 1h-imidazole-4-ethanamine dihydrochloride, 2-(1h-imidazol-4-yl)ethanamine dihydrochloride
    Molecular Formula
    C5H11Cl2N3
    Molecular Weight
    184.06  g/mol
    InChI Key
    PPZMYIBUHIPZOS-UHFFFAOYSA-N
    FDA UNII
    3POA0Q644U
    Histamine Dihydrochloride
    An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
    1 2D Structure

    Histamine Dihydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
    2.1.2 InChI
    InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
    2.1.3 InChI Key
    PPZMYIBUHIPZOS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=C(NC=N1)CCN.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    3POA0Q644U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ceplene

    2. Histamine

    3. Histamine Hydrochloride

    4. Peremin

    2.3.2 Depositor-Supplied Synonyms

    1. 56-92-8

    2. Histamine 2hcl

    3. Ceplene

    4. Peremin

    5. 1h-imidazole-4-ethanamine Dihydrochloride

    6. 2-(1h-imidazol-4-yl)ethanamine Dihydrochloride

    7. 1h-imidazole-4-ethanamine, Dihydrochloride

    8. 2-(4-imidazolyl)ethylamine Dihydrochloride

    9. 2-(1h-imidazol-4-yl)ethylamine Dihydrochloride

    10. Histaminedihydrochloride

    11. Mfcd00012703

    12. Histamine Chloride

    13. Histamine Dihcl

    14. Histamine Dichloride

    15. Histamine Dihydrochloride [usan]

    16. 2-imidazol-4-ylethylamine Dihydrochloride

    17. Histaminedium Dichloride

    18. Histamine Hcl

    19. 4-(2-aminoethyl)imidazole Dihydrochloride

    20. Histamine Dichlorhydrate

    21. Histaminum Hydrochloricum

    22. 2-(1h-imidazol-5-yl)ethanamine Dihydrochloride

    23. Histamine (dihydrochloride)

    24. 2-(1h-imidazol-4-yl)ethan-1-amine Dihydrochloride

    25. Histamine, Dihydrochloride

    26. 3poa0q644u

    27. Nsc-257873

    28. 1h-imidazole-5-ethanamine, Hydrochloride (1:2)

    29. Bichlorhydrated'histamine

    30. Histamine Dihydrochloride (usan)

    31. 2-(1h-imidazol-4-yl)ethanamine;dihydrochloride

    32. Sr-01000075270

    33. Bichlorhydrate D'histamine [french]

    34. Einecs 200-298-4

    35. Bichlorhydrate D'histamine

    36. Nsc 257873

    37. Unii-3poa0q644u

    38. Ai3-24394

    39. Ceplene (tn)

    40. Histamine Dihydrocloride

    41. 2-(1h-imidazol-5-yl)ethanamine;dihydrochloride

    42. C5h9n3.2hcl

    43. Schembl58710

    44. Spectrum1500331

    45. Chembl1533310

    46. Dtxsid1058767

    47. Schembl16778301

    48. Timtec-bb Sbb003722

    49. Hms1920d11

    50. Act02743

    51. Bcp16313

    52. Hy-b0722

    53. Str02021

    54. Tox21_500595

    55. Ccg-38567

    56. Mfcd08060928

    57. S4118

    58. Histamine Dihydrochloride [mi]

    59. Akos015894236

    60. Akos016353223

    61. Ac-7507

    62. Bs-3141

    63. Cs-w020699

    64. Histamine Hydrochloride [mart.]

    65. Ks-5310

    66. Lp00595

    67. Histamine Hydrochloride [who-dd]

    68. Histaminum Hydrochloricum [hpus]

    69. Ncgc00093973-01

    70. Ncgc00093973-02

    71. Ncgc00093973-03

    72. Ncgc00261280-01

    73. 2-(4-imidazolyl)ethylaminedihydrochloride

    74. 4-(2-aminoethyl)imidazole Dihydorchloride

    75. Bp-12001

    76. Histamine Dihydrochloride [usp-rs]

    77. Sy012860

    78. Db-019204

    79. Histamine Dihydrochloride [ema Epar]

    80. Histamine Dihydrochloride, >=99.0% (at)

    81. Eu-0100595

    82. Ft-0627074

    83. H0146

    84. Sw219552-1

    85. En300-75558

    86. 4-(2-aminoethyl)-1h-imidazole Dihydrochloride

    87. D04444

    88. Edihydrochlorideavailablefrom1kgto100kg.

    89. H 7250

    90. H-2250

    91. H-2255

    92. Histamine Dihydrochloride [ep Monograph]

    93. 012h703

    94. A831236

    95. Histamine Dihydrochloride, >=99% (tlc), Powder

    96. 1h-imidazole-4-ethanamine, Chloride (1:1)

    97. 2-(1h-imidazol-5-yl)ethan-1-amine Dihydrochloride

    98. Q5772985

    99. Sr-01000075270-1

    100. Sr-01000075270-7

    101. Histamine Dihydrochloride, Tested According To Ph Eur

    102. F2191-0277

    103. Histamine Dihydrochloride, Saj Special Grade, >=98.0%

    104. Histamine Dihydrochloride, Vetec(tm) Reagent Grade, 98%

    105. Z1267773750

    106. 2-(1h-imidazol-5-yl)ethanamine Dihydrochloride, Aldrichcpr

    107. 2-(1h-imidazol-5-yl)ethanamine Hydrochloride (1:1)

    108. Histamine Dihydrochloride 100 Microg/ml In Acetonitrile:water

    109. Histamine Dihydrochloride, European Pharmacopoeia (ep) Reference Standard

    110. Allergen Scratch Extract Positive Control 'torii' Histamine Dihydrochloride

    111. Histamine Dihydrochloride, United States Pharmacopeia (usp) Reference Standard

    112. 2-(4-imidazolyl)ethylamine Dihydrochloride; 2-(1h-imidazol-4-yl)ethylamine Dihydrochloride;histamine 2hcl

    2.3.3 Other Synonyms

    1. Ergamine

    2. Ergotidine

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 184.06 g/mol
    Molecular Formula C5H11Cl2N3
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass183.0330028 g/mol
    Monoisotopic Mass183.0330028 g/mol
    Topological Polar Surface Area54.7 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity64.7
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Ceplene maintenance therapy is indicated for adult patients with acute myeloid leukaemia in first remission concomitantly treated with interleukin-2 (IL-2). The efficacy of Ceplene has not been fully demonstrated in patients older than age 60.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine Agonists

    Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)

    5.2 ATC Code

    L03AX14

    L - Antineoplastic and immunomodulating agents

    L03 - Immunostimulants

    L03A - Immunostimulants

    L03AX - Other immunostimulants

    L03AX14 - Histamine dihydrochloride

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    ABOUT THIS PAGE

    Histamine Dihydrochloride Manufacturers

    A Histamine Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Histamine Dihydrochloride, including repackagers and relabelers. The FDA regulates Histamine Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Histamine Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Histamine Dihydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Histamine Dihydrochloride Suppliers

    A Histamine Dihydrochloride supplier is an individual or a company that provides Histamine Dihydrochloride active pharmaceutical ingredient (API) or Histamine Dihydrochloride finished formulations upon request. The Histamine Dihydrochloride suppliers may include Histamine Dihydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Histamine Dihydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Histamine Dihydrochloride USDMF

    A Histamine Dihydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Histamine Dihydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Histamine Dihydrochloride DMFs exist exist since differing nations have different regulations, such as Histamine Dihydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Histamine Dihydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Histamine Dihydrochloride USDMF includes data on Histamine Dihydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Histamine Dihydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Histamine Dihydrochloride suppliers with USDMF on PharmaCompass.

    Histamine Dihydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Histamine Dihydrochloride Drug Master File in Japan (Histamine Dihydrochloride JDMF) empowers Histamine Dihydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Histamine Dihydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Histamine Dihydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Histamine Dihydrochloride suppliers with JDMF on PharmaCompass.

    Histamine Dihydrochloride CEP

    A Histamine Dihydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Histamine Dihydrochloride Certificate of Suitability (COS). The purpose of a Histamine Dihydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Histamine Dihydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Histamine Dihydrochloride to their clients by showing that a Histamine Dihydrochloride CEP has been issued for it. The manufacturer submits a Histamine Dihydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Histamine Dihydrochloride CEP holder for the record. Additionally, the data presented in the Histamine Dihydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Histamine Dihydrochloride DMF.

    A Histamine Dihydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Histamine Dihydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Histamine Dihydrochloride suppliers with CEP (COS) on PharmaCompass.

    Histamine Dihydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Histamine Dihydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Histamine Dihydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Histamine Dihydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Histamine Dihydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Histamine Dihydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Histamine Dihydrochloride suppliers with NDC on PharmaCompass.

    Histamine Dihydrochloride GMP

    Histamine Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Histamine Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Histamine Dihydrochloride GMP manufacturer or Histamine Dihydrochloride GMP API supplier for your needs.

    Histamine Dihydrochloride CoA

    A Histamine Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Histamine Dihydrochloride's compliance with Histamine Dihydrochloride specifications and serves as a tool for batch-level quality control.

    Histamine Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Histamine Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Histamine Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Histamine Dihydrochloride EP), Histamine Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Histamine Dihydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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