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    Chemistry

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    Also known as: Homatropine methylbromide, Homatropine methobromide, Omatropina metilbromuro, Methylhomatropine bromide, 80-49-9, 8-methylhomatropinium bromide
    Molecular Formula
    C17H24BrNO3
    Molecular Weight
    370.3  g/mol
    InChI Key
    FUFVKLQESJNNAN-UHFFFAOYSA-M
    Homatropine Methylbromide
    Homatropine Methylbromide is the methylbromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine methylbromide, a competitive inhibitor of acetylcholine at the muscarinic receptor, blocks parasympathetic nerve stimulation, thereby inhibiting pepsin and gastrin secretion. When administered in high doses, this drug produces inhibitory effects on acetylcholine activity, specifically on smooth muscle located in the gastrointestinal, biliary, and genitourinary tracts, resulting in an anti-spasmodic effect.
    1 2D Structure

    Homatropine Methylbromide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;bromide
    2.1.2 InChI
    InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1
    2.1.3 InChI Key
    FUFVKLQESJNNAN-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Hmbromide

    2. Homatropine Methylbromide

    3. Homatropine Methylbromide Iodide, (3(r)-endo)-isomer

    4. Homatropine Methylbromide Iodide, (3(s)-endo)-isomer

    5. Homatropine Methylbromide, (3(r)-endo)-isomer

    6. Homatropine Methylbromide, (3(s)-endo)-isomer

    7. Homatropine Methylbromide, Endo-(+-)-isomer

    2.2.2 Depositor-Supplied Synonyms

    1. Homatropine Methylbromide

    2. Homatropine Methobromide

    3. Omatropina Metilbromuro

    4. Methylhomatropine Bromide

    5. 80-49-9

    6. 8-methylhomatropinium Bromide

    7. Tropinium Methobromide Mandelate

    8. Homatropine Methyl Bromide

    9. Methylhomatropinum Bromatum

    10. Methylbromure D'homatropine

    11. 3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropanium Bromide Mandelate

    12. Nsc34399

    13. Schembl77827

    14. Chebi:50373

    15. Akos015896228

    16. Db00725

    17. 3-[2-hydroxy(phenyl)acetoxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane Bromide

    18. Ncgc00094694-01

    19. Ncgc00094694-02

    20. Db-056442

    21. D90875

    22. H-2560

    2.3 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 370.3 g/mol
    Molecular Formula C17H24BrNO3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass369.09396 g/mol
    Monoisotopic Mass369.09396 g/mol
    Topological Polar Surface Area46.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity374
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Homatropine methylbromide belongs to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

    5.2 ATC Code

    A - Alimentary tract and metabolism

    A03 - Drugs for functional gastrointestinal disorders

    A03B - Belladonna and derivatives, plain

    A03BB - Belladonna alkaloids, semisynthetic, quaternary ammonium compounds

    A03BB06 - Homatropine methylbromide

    5.3 Mechanism of Action

    Homatropine is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Homatropine methylbromide inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.

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    28-Jan-2021
    23-Jan-2025
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    ABOUT THIS PAGE

    Looking for 80-49-9 / Homatropine Methylbromide API manufacturers, exporters & distributors?

    Homatropine Methylbromide manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Homatropine Methylbromide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Homatropine Methylbromide manufacturer or Homatropine Methylbromide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Homatropine Methylbromide manufacturer or Homatropine Methylbromide supplier.

    PharmaCompass also assists you with knowing the Homatropine Methylbromide API Price utilized in the formulation of products. Homatropine Methylbromide API Price is not always fixed or binding as the Homatropine Methylbromide Price is obtained through a variety of data sources. The Homatropine Methylbromide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Homatropine Methylbromide

    Synonyms

    Homatropine methobromide, Omatropina metilbromuro, Methylhomatropine bromide, 80-49-9, 8-methylhomatropinium bromide, Tropinium methobromide mandelate

    Cas Number

    80-49-9

    About Homatropine Methylbromide

    Homatropine Methylbromide is the methylbromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine methylbromide, a competitive inhibitor of acetylcholine at the muscarinic receptor, blocks parasympathetic nerve stimulation, thereby inhibiting pepsin and gastrin secretion. When administered in high doses, this drug produces inhibitory effects on acetylcholine activity, specifically on smooth muscle located in the gastrointestinal, biliary, and genitourinary tracts, resulting in an anti-spasmodic effect.

    Homatropine Methylbromide Manufacturers

    A Homatropine Methylbromide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Homatropine Methylbromide, including repackagers and relabelers. The FDA regulates Homatropine Methylbromide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Homatropine Methylbromide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Homatropine Methylbromide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Homatropine Methylbromide Suppliers

    A Homatropine Methylbromide supplier is an individual or a company that provides Homatropine Methylbromide active pharmaceutical ingredient (API) or Homatropine Methylbromide finished formulations upon request. The Homatropine Methylbromide suppliers may include Homatropine Methylbromide API manufacturers, exporters, distributors and traders.

    click here to find a list of Homatropine Methylbromide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Homatropine Methylbromide USDMF

    A Homatropine Methylbromide DMF (Drug Master File) is a document detailing the whole manufacturing process of Homatropine Methylbromide active pharmaceutical ingredient (API) in detail. Different forms of Homatropine Methylbromide DMFs exist exist since differing nations have different regulations, such as Homatropine Methylbromide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Homatropine Methylbromide DMF submitted to regulatory agencies in the US is known as a USDMF. Homatropine Methylbromide USDMF includes data on Homatropine Methylbromide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Homatropine Methylbromide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Homatropine Methylbromide suppliers with USDMF on PharmaCompass.

    Homatropine Methylbromide CEP

    A Homatropine Methylbromide CEP of the European Pharmacopoeia monograph is often referred to as a Homatropine Methylbromide Certificate of Suitability (COS). The purpose of a Homatropine Methylbromide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Homatropine Methylbromide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Homatropine Methylbromide to their clients by showing that a Homatropine Methylbromide CEP has been issued for it. The manufacturer submits a Homatropine Methylbromide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Homatropine Methylbromide CEP holder for the record. Additionally, the data presented in the Homatropine Methylbromide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Homatropine Methylbromide DMF.

    A Homatropine Methylbromide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Homatropine Methylbromide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Homatropine Methylbromide suppliers with CEP (COS) on PharmaCompass.

    Homatropine Methylbromide WC

    A Homatropine Methylbromide written confirmation (Homatropine Methylbromide WC) is an official document issued by a regulatory agency to a Homatropine Methylbromide manufacturer, verifying that the manufacturing facility of a Homatropine Methylbromide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Homatropine Methylbromide APIs or Homatropine Methylbromide finished pharmaceutical products to another nation, regulatory agencies frequently require a Homatropine Methylbromide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Homatropine Methylbromide suppliers with Written Confirmation (WC) on PharmaCompass.

    Homatropine Methylbromide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Homatropine Methylbromide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Homatropine Methylbromide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Homatropine Methylbromide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Homatropine Methylbromide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Homatropine Methylbromide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Homatropine Methylbromide suppliers with NDC on PharmaCompass.

    Homatropine Methylbromide GMP

    Homatropine Methylbromide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Homatropine Methylbromide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Homatropine Methylbromide GMP manufacturer or Homatropine Methylbromide GMP API supplier for your needs.

    Homatropine Methylbromide CoA

    A Homatropine Methylbromide CoA (Certificate of Analysis) is a formal document that attests to Homatropine Methylbromide's compliance with Homatropine Methylbromide specifications and serves as a tool for batch-level quality control.

    Homatropine Methylbromide CoA mostly includes findings from lab analyses of a specific batch. For each Homatropine Methylbromide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Homatropine Methylbromide may be tested according to a variety of international standards, such as European Pharmacopoeia (Homatropine Methylbromide EP), Homatropine Methylbromide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Homatropine Methylbromide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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