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Chemistry

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Also known as: 1421783-64-3, Gzd824, Gzd-824 dimesylate, D-824 dimesylate, Npj9aw8azr, Olverembatinib (dimesylate)
Molecular Formula
C31H35F3N6O7S2
Molecular Weight
724.8  g/mol
InChI Key
LEVIGHXVOVROGW-UHFFFAOYSA-N
FDA UNII
NPJ9AW8AZR

HQP1351
1 2D Structure

HQP1351

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methanesulfonic acid;4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
2.1.2 InChI
InChI=1S/C29H27F3N6O.2CH4O3S/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38;2*1-5(2,3)4/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36);2*1H3,(H,2,3,4)
2.1.3 InChI Key
LEVIGHXVOVROGW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4.CS(=O)(=O)O.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
NPJ9AW8AZR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-((1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

2. 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)benzamide

3. Benzamide, 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, Methanesulfonate (1:2)

4. D-824

5. D-824 Dimesylate

6. D824

7. Gzd-824

8. Gzd-824 Dimesylate

9. Gzd824

10. Hqp-1351

11. Hqp-1351 Dimesylate

12. Hqp1351

13. Hqp1351 Dimesylate

14. Olverembatinib

15. Olverembatinib Dimesylate

2.3.2 Depositor-Supplied Synonyms

1. 1421783-64-3

2. Gzd824

3. Gzd-824 Dimesylate

4. D-824 Dimesylate

5. Npj9aw8azr

6. Olverembatinib (dimesylate)

7. Methanesulfonic Acid;4-methyl-n-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

8. Olverembatinib Dimesylate

9. Hqp1351 Dimesylate

10. Hqp-1351 Dimesylate

11. Benzamide, 4-methyl-n-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1h-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, Methanesulfonate (1:2)

12. Unii-npj9aw8azr

13. Schembl14953403

14. Hms3653c17

15. Bcp11025

16. Ex-a1365

17. Hy-15666a

18. Akos026750482

19. Ccg-270412

20. Ac-35746

21. Db-085418

22. Cs-0020021

23. S7194

24. Sw219345-1

25. 3-((1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Dimethanesulfonate

2.4 Create Date
2013-06-11
3 Chemical and Physical Properties
Molecular Weight 724.8 g/mol
Molecular Formula C31H35F3N6O7S2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count6
Exact Mass724.19607431 g/mol
Monoisotopic Mass724.19607431 g/mol
Topological Polar Surface Area203 Ų
Heavy Atom Count49
Formal Charge0
Complexity1000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

ABOUT THIS PAGE

HQP1351 Manufacturers

A HQP1351 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of HQP1351, including repackagers and relabelers. The FDA regulates HQP1351 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. HQP1351 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

HQP1351 Suppliers

A HQP1351 supplier is an individual or a company that provides HQP1351 active pharmaceutical ingredient (API) or HQP1351 finished formulations upon request. The HQP1351 suppliers may include HQP1351 API manufacturers, exporters, distributors and traders.

HQP1351 GMP

HQP1351 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of HQP1351 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right HQP1351 GMP manufacturer or HQP1351 GMP API supplier for your needs.

HQP1351 CoA

A HQP1351 CoA (Certificate of Analysis) is a formal document that attests to HQP1351's compliance with HQP1351 specifications and serves as a tool for batch-level quality control.

HQP1351 CoA mostly includes findings from lab analyses of a specific batch. For each HQP1351 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

HQP1351 may be tested according to a variety of international standards, such as European Pharmacopoeia (HQP1351 EP), HQP1351 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (HQP1351 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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