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    Chemistry

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    Also known as: Hyaluronic acid, sodium salt, Hyaluronic acid sodium, Kopuron, Healon, Hyalgan, Hyalurone sodium
    Molecular Formula
    C28H44N2NaO23+
    Molecular Weight
    799.6  g/mol
    InChI Key
    YWIVKILSMZOHHF-QJZPQSOGSA-N
    Sodium Hyaluronate
    A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
    1 2D Structure

    Sodium Hyaluronate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
    2.1.2 InChI
    InChI=1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
    2.1.3 InChI Key
    YWIVKILSMZOHHF-QJZPQSOGSA-N
    2.1.4 Canonical SMILES
    CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
    2.1.5 Isomeric SMILES
    CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Acid, Hyaluronic

    2. Amo Vitrax

    3. Amvisc

    4. Biolon

    5. Etamucine

    6. Healon

    7. Hyaluronate Sodium

    8. Hyaluronate, Sodium

    9. Hyaluronic Acid

    10. Hyvisc

    11. Luronit

    12. Vitrax, Amo

    2.2.2 Depositor-Supplied Synonyms

    1. Hyaluronic Acid, Sodium Salt

    2. Hyaluronic Acid Sodium

    3. Kopuron

    4. Healon

    5. Hyalgan

    6. Hyalurone Sodium

    7. 6-[3-acetamido-2-[6-[3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic Acid

    8. Sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic Acid

    9. Equron (veterinary)

    10. Synacid (veterinary)

    11. Arthrease

    12. Cystistat

    13. Hyalart

    14. Hyalein

    15. Hyalovet

    16. Hyladerm

    17. Khionat

    18. Monovisc

    19. Nidelon

    20. Orthovisc

    21. Ostenil

    22. Provisc

    23. Sinovial

    24. Supartz

    25. Suvenyl

    26. Hyasol

    27. Hyladerm Khionat

    28. Nrd101

    29. Ha

    30. Hyaluronsan Ha-lq

    31. Bio Hyaluro 12

    32. Euflexxa Injection

    33. Euflexxa

    34. Ccris 4127

    35. Hyaluronate Sodium [usan:jan]

    36. Sodium Hyaluronate Hmw

    37. Unii-yse9ppt4th

    38. Si-4402

    39. Sl-1010

    40. Synacid

    41. Equron

    42. Chlamyhyaluronic Acid Sodium Salt

    43. Sl 1010

    44. Hyalauronic Acid 99%

    45. Yse9ppt4th

    46. Gtpl4954

    47. Sodium Hyaluronate (food Grade)

    48. Sodium Hyaluronate (cosmetic Grade)

    49. Akos015896610

    50. Sodium Hyaluronate, Low Molecular Weight

    51. Sodium Hyaluronate, High Molecular Weight

    52. Q27078001

    53. (3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-4-[(2s,3r,4s,6s)-6-carboxy-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dih

    54. Sodium (2s,3s,4r,5r,6r)-3-{[(2s,3r,4r,5s,6r)-4-{[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic Acid

    2.3 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 799.6 g/mol
    Molecular Formula C28H44N2NaO23+
    Hydrogen Bond Donor Count14
    Hydrogen Bond Acceptor Count23
    Rotatable Bond Count12
    Exact Mass799.22325494 g/mol
    Monoisotopic Mass799.22325494 g/mol
    Topological Polar Surface Area400 Ų
    Heavy Atom Count54
    Formal Charge1
    Complexity1300
    Isotope Atom Count0
    Defined Atom Stereocenter Count20
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adjuvants, Immunologic

    Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

    Viscosupplements

    Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS. (See all compounds classified as Viscosupplements.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Vitamin B 6 [Chemical/Ingredient]; Vitamin B6 Analog [EPC]; Analogs/Derivatives [Chemical/Ingredient]

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    08-Jan-2021
    04-Dec-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
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    ABOUT THIS PAGE

    Hyaluronate Sodium Manufacturers

    A Hyaluronate Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hyaluronate Sodium, including repackagers and relabelers. The FDA regulates Hyaluronate Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hyaluronate Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Hyaluronate Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Hyaluronate Sodium Suppliers

    A Hyaluronate Sodium supplier is an individual or a company that provides Hyaluronate Sodium active pharmaceutical ingredient (API) or Hyaluronate Sodium finished formulations upon request. The Hyaluronate Sodium suppliers may include Hyaluronate Sodium API manufacturers, exporters, distributors and traders.

    click here to find a list of Hyaluronate Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Hyaluronate Sodium USDMF

    A Hyaluronate Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Hyaluronate Sodium active pharmaceutical ingredient (API) in detail. Different forms of Hyaluronate Sodium DMFs exist exist since differing nations have different regulations, such as Hyaluronate Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Hyaluronate Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Hyaluronate Sodium USDMF includes data on Hyaluronate Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hyaluronate Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Hyaluronate Sodium suppliers with USDMF on PharmaCompass.

    Hyaluronate Sodium JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Hyaluronate Sodium Drug Master File in Japan (Hyaluronate Sodium JDMF) empowers Hyaluronate Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Hyaluronate Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Hyaluronate Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Hyaluronate Sodium suppliers with JDMF on PharmaCompass.

    Hyaluronate Sodium KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Hyaluronate Sodium Drug Master File in Korea (Hyaluronate Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Hyaluronate Sodium. The MFDS reviews the Hyaluronate Sodium KDMF as part of the drug registration process and uses the information provided in the Hyaluronate Sodium KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Hyaluronate Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Hyaluronate Sodium API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Hyaluronate Sodium suppliers with KDMF on PharmaCompass.

    Hyaluronate Sodium CEP

    A Hyaluronate Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Hyaluronate Sodium Certificate of Suitability (COS). The purpose of a Hyaluronate Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Hyaluronate Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Hyaluronate Sodium to their clients by showing that a Hyaluronate Sodium CEP has been issued for it. The manufacturer submits a Hyaluronate Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Hyaluronate Sodium CEP holder for the record. Additionally, the data presented in the Hyaluronate Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Hyaluronate Sodium DMF.

    A Hyaluronate Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Hyaluronate Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Hyaluronate Sodium suppliers with CEP (COS) on PharmaCompass.

    Hyaluronate Sodium WC

    A Hyaluronate Sodium written confirmation (Hyaluronate Sodium WC) is an official document issued by a regulatory agency to a Hyaluronate Sodium manufacturer, verifying that the manufacturing facility of a Hyaluronate Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Hyaluronate Sodium APIs or Hyaluronate Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Hyaluronate Sodium WC (written confirmation) as part of the regulatory process.

    click here to find a list of Hyaluronate Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

    Hyaluronate Sodium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Hyaluronate Sodium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Hyaluronate Sodium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Hyaluronate Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Hyaluronate Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Hyaluronate Sodium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Hyaluronate Sodium suppliers with NDC on PharmaCompass.

    Hyaluronate Sodium GMP

    Hyaluronate Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Hyaluronate Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hyaluronate Sodium GMP manufacturer or Hyaluronate Sodium GMP API supplier for your needs.

    Hyaluronate Sodium CoA

    A Hyaluronate Sodium CoA (Certificate of Analysis) is a formal document that attests to Hyaluronate Sodium's compliance with Hyaluronate Sodium specifications and serves as a tool for batch-level quality control.

    Hyaluronate Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Hyaluronate Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Hyaluronate Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Hyaluronate Sodium EP), Hyaluronate Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hyaluronate Sodium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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