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Chemistry

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Also known as: Ncgc00167966-01, Dsstox_cid_26750, Dsstox_rid_81875, Dsstox_gsid_46750, Chembl1874250, Dtxsid20858848
Molecular Formula
C28H44N2O23
Molecular Weight
776.6  g/mol
InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N

Hyaluronic Acid
1 2D Structure

Hyaluronic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,4S,5R,6S)-6-[(2S,3R,5S,6R)-3-acetamido-2-[(3S,4R,5R,6R)-6-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14?,15-,16-,17-,18-,19?,20+,21+,22?,25?,26+,27+,28-/m1/s1
2.1.3 InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N
2.1.4 Canonical SMILES
CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.1.5 Isomeric SMILES
CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H](C(O2)C(=O)O)O[C@H]3[C@@H](C([C@@H]([C@H](O3)CO)O)O[C@@H]4[C@@H]([C@H](C([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Ncgc00167966-01

2. Dsstox_cid_26750

3. Dsstox_rid_81875

4. Dsstox_gsid_46750

5. Chembl1874250

6. Dtxsid20858848

7. Tox21_112595

8. Akos015960603

9. Ac-11740

10. Ac-31947

11. Cas-9004-61-9

12. (4xi)-alpha-d-xylo-hexopyranuronosyl-(1->3)-(3xi)-2-(acetylamino)-2-deoxy-beta-d-ribo-hexopyranosyl-(1->4)-(5xi)-beta-d-xylo-hexopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-d-glucopyranose

2.2.2 Other Synonyms

1. Hyaluronan

2.3 Create Date
2008-02-29
3 Chemical and Physical Properties
Molecular Weight 776.6 g/mol
Molecular Formula C28H44N2O23
XLogP3-7.4
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count23
Rotatable Bond Count12
Exact Mass776.23348565 g/mol
Monoisotopic Mass776.23348565 g/mol
Topological Polar Surface Area400 Ų
Heavy Atom Count53
Formal Charge0
Complexity1300
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

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KUSHALCHAND INTERNATIONAL ","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1200","totalValueFC":"6059.7","currency":"USD","unitRateINR":"100920","date":"27-Nov-2023","totalValueINR":"504600","totalValueInUsd":"6059.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8953831","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"IC30 PASIR PANJANG ROAD,# 13-31, ,MAPLETREE BUSINESS CITY,117440SDNF SINGAPORE","customerAddress":"1601 16TH FLR G WING,LOTUS CORPOR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704652200,"product":"HYALURONIC ACID","address":"184, HARIOM AVAS","city":"SURAT","supplier":"EFFEPHARM LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"CENTENARIANS LIFE SCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"300","totalValueFC":"1846.6","currency":"USD","unitRateINR":"25579.3","date":"08-Jan-2024","totalValueINR":"153475.87","totalValueInUsd":"1846.6","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9571149","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"BLD 4, NO.1, MID WANGZHONG RD, SHANGHAI, Shanghai, , CHINASDNF CHINA","customerAddress":"184, HARIOM AVAS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705689000,"product":"HYALURONIC ACID","address":"184, HARIOM AVAS","city":"SURAT","supplier":"EFFEPHARM LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"CENTENARIANS LIFE SCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"300","totalValueFC":"4600.7","currency":"USD","unitRateINR":"25491.5","date":"20-Jan-2024","totalValueINR":"382371.76","totalValueInUsd":"4600.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9747754","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"BLD 4, NO.1, MID WANGZHONG RD, SHANGHAI, Shanghai, , CHINASDNF CHINA","customerAddress":"184, HARIOM AVAS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714933800,"product":"HYALURONIC ACID-BT (C.O CZECH REPUBLIC)","address":"1601 16TH FLR G WING,LOTUS CORPOR","city":"MUMBAI,MAHARASHTRA","supplier":"ROYAL DSM","supplierCountry":"CHINA","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"S. KUSHALCHAND INTERNATIONAL ","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1200","totalValueFC":"2428.7","currency":"USD","unitRateINR":"101220","date":"06-May-2024","totalValueINR":"202440","totalValueInUsd":"2428.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3352123","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"IC30 PASIR PANJANG ROAD,# 13-31, ,MAPLETREE BUSINESS CITY,117440SDNF SINGAPORE","customerAddress":"1601 16TH FLR G WING,LOTUS CORPOR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720722600,"product":"HYALURONIC ACID BT - (C.O - CZECH REPUBLIC)","address":"1601 16TH FLR G WING,LOTUS CORPOR","city":"MUMBAI,MAHARASHTRA","supplier":"ROYAL DSM","supplierCountry":"SWITZERLAND","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"S. KUSHALCHAND INTERNATIONAL ","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1200","totalValueFC":"2424.7","currency":"USD","unitRateINR":"101340","date":"12-Jul-2024","totalValueINR":"202680","totalValueInUsd":"2424.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4461589","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"IC30 PASIR PANJANG ROAD,# 13-31, ,MAPLETREE BUSINESS CITY,117440SDNF SINGAPORE","customerAddress":"1601 16TH FLR G WING,LOTUS CORPOR"}]
23-Nov-2021
21-Oct-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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Drugs in Development

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Details:

Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.


Lead Product(s): Hyaluronic Acid

Therapeutic Area: Dermatology Brand Name: Skinvive

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 15, 2023

Abbvie Company Banner

01

AbbVie Inc

U.S.A
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BioFlorida Conference
Not Confirmed

Details : Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.

Brand Name : Skinvive

Molecule Type : Small molecule

Upfront Cash : Not Applicable

May 15, 2023

Abbvie Company Banner

Details:

Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.


Lead Product(s): Hyaluronic Acid

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 18, 2023

Abbvie CB

02

BioFlorida Conference
Not Confirmed

Details : Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.

Brand Name : Juvederm Volux XC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 18, 2023

Abbvie CB

Details:

Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapatite in one injection.


Lead Product(s): Hyaluronic Acid,HYDROXYPROPYLMETHYLCELLULOSE

Therapeutic Area: Dermatology Brand Name: HArmonyCa

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 29, 2022

Abbvie CB

03

BioFlorida Conference
Not Confirmed

Details : Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapa...

Brand Name : HArmonyCa

Molecule Type : Small molecule

Upfront Cash : Not Applicable

March 29, 2022

Abbvie CB

Details:

JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indication in the U.S.


Lead Product(s): Hyaluronic Acid,Lidocaine

Therapeutic Area: Dermatology Brand Name: Juvéderm Volbella XC

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 08, 2022

Abbvie CB

04

BioFlorida Conference
Not Confirmed

Details : JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indicatio...

Brand Name : Juvéderm Volbella XC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

February 08, 2022

Abbvie CB

Details:

JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 21.


Lead Product(s): Hyaluronic Acid

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 15, 2020

Abbvie CB

05

BioFlorida Conference
Not Confirmed

Details : JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 2...

Brand Name : Juvederm Volux XC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 15, 2020

Abbvie CB

Details:

New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.


Lead Product(s): Hyaluronic Acid,Dermatan Sulfate,Collagen

Therapeutic Area: Dermatology Brand Name: Dermial

Study Phase: PreclinicalProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 25, 2022

Bioiberica Company Banner

06

Bioiberica

Spain
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BioFlorida Conference
Not Confirmed

Lead Product(s) : Hyaluronic Acid,Dermatan Sulfate,Collagen

Therapeutic Area : Dermatology

Highest Development Status : Preclinical

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.

Brand Name : Dermial

Molecule Type : Small molecule

Upfront Cash : Not Applicable

May 25, 2022

Bioiberica Company Banner

Details:

Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint function.


Lead Product(s): Hyaluronic Acid,Type II Collagen

Therapeutic Area: Musculoskeletal Brand Name: Motilex HA

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Apsen

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership April 26, 2021

Bioiberica Company Banner

07

Bioiberica

Spain
arrow
BioFlorida Conference
Not Confirmed

Lead Product(s) : Hyaluronic Acid,Type II Collagen

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Apsen

Deal Size : Undisclosed

Deal Type : Partnership

Details : Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint...

Brand Name : Motilex HA

Molecule Type : Small molecule

Upfront Cash : Undisclosed

April 26, 2021

Bioiberica Company Banner

Details:

The study, conducted in a rabbit model of osteoarthritis, set out to evaluate the effects of b-2Cool native type II collagen in combination with CS b-Bioactive chondroitin sulphate, glucosamine hydrochloride and Mobilee® which is a rooster comb extract rich in hyaluronic acid.


Lead Product(s): Undenatured Type II Collagen,Chondroitin Sulfate Sodium,Hyaluronic Acid

Therapeutic Area: Musculoskeletal Brand Name: Mobilee

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 07, 2020

Bioiberica Company Banner

08

Bioiberica

Spain
arrow
BioFlorida Conference
Not Confirmed

Lead Product(s) : Undenatured Type II Collagen,Chondroitin Sulfate Sodium,Hyaluronic Acid

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : The study, conducted in a rabbit model of osteoarthritis, set out to evaluate the effects of b-2Cool native type II collagen in combination with CS b-Bioactive chondroitin sulphate, glucosamine hydrochloride and Mobilee® which is a rooster comb extract ...

Brand Name : Mobilee

Molecule Type : Large molecule

Upfront Cash : Not Applicable

September 07, 2020

Bioiberica Company Banner

Details:

B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.


Lead Product(s): Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid

Therapeutic Area: Musculoskeletal Brand Name: Colnatur Forte

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 15, 2020

Bioiberica Company Banner

09

Bioiberica

Spain
arrow
BioFlorida Conference
Not Confirmed

Lead Product(s) : Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.

Brand Name : Colnatur Forte

Molecule Type : Large molecule

Upfront Cash : Not Applicable

July 15, 2020

Bioiberica Company Banner

Details:

Bloomsurfact EncapCare (hyaluronic acid) is an emulsion solution for effective anti-aging skin rejuvenation & ensures high bioavailability & low irritation making it more friendly for sensitive skin.


Lead Product(s): Hyaluronic Acid

Therapeutic Area: Dermatology Brand Name: Bloomsurfact EncapCare

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 12, 2023

Bloomage Company Banner

10

BioFlorida Conference
Not Confirmed

Lead Product(s) : Hyaluronic Acid

Therapeutic Area : Dermatology

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : Bloomsurfact EncapCare (hyaluronic acid) is an emulsion solution for effective anti-aging skin rejuvenation & ensures high bioavailability & low irritation making it more friendly for sensitive skin.

Brand Name : Bloomsurfact EncapCare

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 12, 2023

Bloomage Company Banner
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