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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 17 USDMF, 1 KDMF, 18 NDC API, 10 Listed Suppliers

23 API Suppliers
17 USDMF
1 KDMF
18 NDC API
10 Listed Suppliers

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

344 FDF Dossiers, 337 FDA Orange Book, 3 Canada, 4 Listed Dossiers

344 FDF Dossiers
337 FDA Orange Book
3 Canada
4 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE, EXTENDED RELEASE;ORAL - 10MG, CAPSULE, EXTENDED RELEASE;ORAL - 15MG, CAPSULE, EXTENDED RELEASE;ORAL - 20MG, CAPSULE, EXTENDED RELEASE;ORAL - 30MG, CAPSULE, EXTENDED RELEASE;ORAL - 40MG, CAPSULE, EXTENDED RELEASE;ORAL - 50MG, SOLUTION;ORAL - 4MG/5ML;5MG/5ML, SOLUTION;ORAL - 200MG/5ML;2.5MG/5ML, SOLUTION;ORAL - 200MG/5ML;2.5MG/5ML;30MG/5ML, SOLUTION;ORAL - 4MG/5ML;5MG/5ML;60MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION;ORAL - 5MG/5ML;60MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - 1.5MG;5MG

drugProductComposition
CAPSULE, EXTENDED RELEASE;ORAL - 10MG
CAPSULE, EXTENDED RELEASE;ORAL - 15MG
CAPSULE, EXTENDED RELEASE;ORAL - 20MG
CAPSULE, EXTENDED RELEASE;ORAL - 30MG
CAPSULE, EXTENDED RELEASE;ORAL - 40MG
CAPSULE, EXTENDED RELEASE;ORAL - 50MG
SOLUTION;ORAL - 4MG/5ML;5MG/5ML
SOLUTION;ORAL - 200MG/5ML;2.5MG/5ML
SOLUTION;ORAL - 200MG/5ML;2.5MG/5ML;30MG/5ML
SOLUTION;ORAL - 4MG/5ML;5MG/5ML;60MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
SOLUTION;ORAL - 5MG/5ML;60MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 1.5MG;5MG

RELATED EXCIPIENT COMPANIES

1 Evonik, 5 Rochem International Inc, 6 SPI Pharma, 2 Seqens, 11 DKSH, 2 Jai Radhe Sales, 2 Pharm-RX Chemical, 10 Boai NKY Pharmaceuticals Ltd, 15 Gangwal Healthcare, 7 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 14 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 35 BASF, 1 Bioplus Life Sciences, 1 Clariant, 16 Corel Pharma Chem, 7 DFE Pharma, 2 Finar, 13 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 7 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 38 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 16 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 5 Novo Excipients, 4 Pharmatrans-Sanaq, 8 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 35 Roquette, 14 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 3 Ulanqab Kema New Material, 1 Valens Pharmachem, 4 Vasa Pharmachem, 1 Vertellus, 3 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Evonik
5 Rochem International Inc
6 SPI Pharma
2 Seqens
11 DKSH
2 Jai Radhe Sales
2 Pharm-RX Chemical
10 Boai NKY Pharmaceuticals Ltd
15 Gangwal Healthcare
7 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
14 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
35 BASF
1 Bioplus Life Sciences
1 Clariant
16 Corel Pharma Chem
7 DFE Pharma
2 Finar
13 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
7 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
38 Kerry
4 Kima Chemical
6 Lonza Capsugel
16 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
5 Novo Excipients
4 Pharmatrans-Sanaq
8 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
35 Roquette
14 Seppic
6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
3 Ulanqab Kema New Material
1 Valens Pharmachem
4 Vasa Pharmachem
1 Vertellus
3 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

99 Fillers, Diluents & Binders, 63 Coating Systems & Additives, 49 Direct Compression, 43 Controlled & Modified Release, 42 Disintegrants & Superdisintegrants, 40 Thickeners and Stabilizers, 34 Granulation, 31 Solubilizers, 31 Film Formers & Plasticizers, 28 Taste Masking, 22 Parenteral, 21 Topical, 21 Lubricants & Glidants, 20 Co-Processed Excipients, 12 Chewable & Orodispersible Aids, 9 Emulsifying Agents, 9 Empty Capsules, 8 API Stability Enhancers, 7 Rheology Modifiers, 5 Coloring Agents, 4 Vegetarian Capsules, 4 Surfactant & Foaming Agents, 1 Soft Gelatin

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 97 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
97 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 6 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
6 Annual Reports

MARKET PLACE

3 APIs, 2 FDF Dossiers

marketPlace
3 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

254 US Patents

patents
254 US Patents

REF. STANDARDS & IMPURITIES

3 USP , 7 Others

otherSolutions
3 USP
7 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

344

FDF Dossiers

337

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

5DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

254

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

933

Annual Reports (USD Million)

555

Finished Drug Prices

355 RELATED EXCIPIENT COMPANIES

603EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: (4r,4ar,7ar,12bs)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic acid, .codon, Schembl154972, Chembl2062267

Molecular Formula

C₂₂H₂₇NO₉

Molecular Weight

449.4 g/mol

InChI Key

OJHZNMVJJKMFGX-RNWHKREASA-N

Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

1 2D Structure

Hydrocodone Bitartrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic acid

2.1.2 InChI

InChI=1S/C18H21NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,17-,18-;/m0./s1

2.1.3 InChI Key

OJHZNMVJJKMFGX-RNWHKREASA-N

2.1.4 Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Codinovo

2. Dicodid

3. Dihydrocodeinone

4. Hycodan

5. Hycon

6. Hydrocodeinonebitartrate

7. Hydrocodon

8. Hydrocodone

9. Hydrocodone Tartrate (1:1), Hydrate (2:5)

10. Hydrocon

11. Robidone

2.2.2 Depositor-Supplied Synonyms

1. (4r,4ar,7ar,12bs)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic Acid

2. .codon

3. Schembl154972

4. Chembl2062267

2.2.3 Other Synonyms

1. Hydrocone

2. Multacodin

3. Hydrocodone

2.3 Create Date

2007-12-05

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₇NO₉
Molecular Weight	449.4 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Exact Mass	449.16858144 g/mol
Monoisotopic Mass	449.16858144 g/mol
Topological Polar Surface Area	154 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	642
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Opioid Agonists [MoA]; Opioid Agonist [EPC]

API SUPPLIERS

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USDMF

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KDMF

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NDC API

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Listed Suppliers

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Drugs in Development

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

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FDA Orange Book

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Canada

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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